How statins might affect brain cholesterol synthesis and cognitive function | Tom Dayspring

Fri, 15 Aug 2025 22:47:18 +0000

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This clip is from episode 334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more with Tom Dayspring, M.D.

In this clip, they discuss:

- Statins suppress cholesterol synthesis in the brain, which may impact cognitive function in sensitive individuals
- Low desmosterol levels correlate with cognitive impairment and may help identify those at risk
- Modern options like ezetimibe, bempedoic acid, and PCSK9 inhibitors allow for effective apoB reduction without high-dose statins
- And more

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