Mon, 18 Aug 2025 12:45:24 +0000

Bone Fracture. Risks of PPIs for Acid Reflux/GERD/Heartburn and bones.

Dr. Waks discuses the FDA communication that links fracture risks to proton pumps inhibitors. Proton Pump Inhibitors are the drugs commonly used to relieve Acid reflux, Heartburn or GERD.
proton pump inhibitors side effects: decreased calcium absorption and fragile bones, osteoporosis.
"There are limited studies on the effects of PPIs on bone health in the younger populations. As peak bone mass is an important determinant of bone health, it is important to know whether PPI use will affect peak bone mass attainment and osteoporosis risk later in adulthood."

Long-term PPI therapy is reported to be associated with decreased bone mineral density (BMD). Reduction in BMD and deterioration of bone microstructure are characteristics of osteoporosis, a metabolic bone disease. Osteoporosis ultimately leads to decreased bone strength and susceptibility to fracture. Osteoporotic fracture is becoming a major health concern in the rapidly aging society, owing to the tremendous economic burden, mortality, and morbidity associated with it. In fact, hip fracture is considered as the most common cause of elevated mortality and dependency in elderly patients.
https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC65402

Some examples of proton pump inhibitors:

Omeprazole (OTC; brand names: Gasec, Losec, Prilosec, Zegerid, Lomac, Omepral, Omez, Omepep, UlcerGard, GastroGard)

Lansoprazole (brand names: Prevacid, Zoton, Monolitum, Inhibitol, Levant, Lupizole)

Dexlansoprazole (brand name: Kapidex, Dexilant)

Esomeprazole (brand names: Nexium, Esotrex, esso)

Pantoprazole (brand names: Protonix, Somac, Pantoloc, Pantozol,

Pantomed, Zurcal, Zentro, Pan, Controloc, Tecta)

Rabeprazole (brand names: AcipHex, Pariet, Erraz, Zechin,

Rabecid, Nzole-D, Rabeloc, Razo. Dorafem: combination with domperidone[citation needed]).

Ilaprazole (not FDA approved as of October 2013; brand names: Noltec, Yili'an, Ilapro, Lupilla, Adiza)

The FDA communication:
http://www.fda.gov/Drugs/DrugS....afety/PostmarketDrug

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8 Common Causes of GERD: https://youtu.be/O6fWR_ahglU.
Identify your cause and then it is not that difficult to choose the correct treatment.
GERD course: http://acid-reflux-and-gerd.com/
Stay healthy
Dr. Veronica