Lacosamide in patients with Nav1.7 mutations-related small fibre neuropathy

Wed, 20 Aug 2025 17:58:17 +0000

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Small fibre neuropathy leads to severe neuropathic pain. In a randomized, double-blind, crossover trial – the LENSS study – de Greef et al. evaluate the efficacy of lacosamide, an anticonvulsant, in patients with SCN9A-associated small fibre neuropathy. Compared with placebo, lacosamide reduces pain and improves sleep quality and general well-being.