Comparison of Fluoxetine (Prozac) vs Sertraline (Zoloft)

Fri, 15 Aug 2025 21:49:51 +0000

In today's video, we compare fluoxetine and sertraline, or Prozac vs Zoloft. When comparing 2 medications it is best to look at the similarities and differences and based off of that decide which one would best treat your symptoms. The best antidepressant is going to be the one you can tolerate and that treats your symptoms.

Intro 0:00
Fluoxetine and Sertraline FDA-approved diagnosis 00:40
Mechanism of action of Fluoxetine 01:55
Sertraline mechanism of action 03:35
Side effects of fluoxetine and sertraline 05:05
Drug interactions of fluoxetine and sertraline 05:50
How fluoxetine and sertraline are taken 07:24

📣 If you need help with your medication or taper plan you can work with Jezel here
🔗 https://www.levelheadedmind.com/

Resources:
Deprescribing Guide: https://amzn.to/4dZEUMk
Stahl's Prescribing Guide: https://amzn.to/3UXj8QL

🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suicide-hotlines/

Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

References
Medical News Today (2019). What are the differences between Prozac and Zoloft? Retrieved from
https://www.medicalnewstoday.c....om/articles/325684#s

Stahl, S. M., Grady, M. M., & Muntner, N. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.

Stahl, S. (2017). Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 6th Ed. Cambridge University Press.

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