Linzess vs. Trulance // Pelvic Empowerment IBS Series Part 8

Wed, 20 Aug 2025 18:21:18 +0000

Black lives matter: https://www.youtube.com/post/U....gwxxLAznBPC95AeoEB4A

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I have gotten a lot of requests surrounding IBS and have decided to do an IBS video series in order to cover the many different topics about IBS that have been requested!

The IBS Series:
1️⃣ What Causes IBS: https://youtu.be/h6x9_RloKGU
2️⃣ IBS Trigger Foods: https://youtu.be/tFh-oO0jruI
3️⃣ IBS Food Sensitivities & Intolerances: https://youtu.be/jNw8C1E6bd8
4️⃣ IBS & Lactose/Gluten Intolerance: https://youtu.be/cV8QrVIYV-s
5️⃣ Soluble vs. Insoluble Fiber: https://youtu.be/I5xWaylSjoU
6️⃣ Dietary Considerations For IBS Symptom Management: https://youtu.be/tKo-bP18KZA
7️⃣ IBS & The Low FODMAPs Diet: https://youtu.be/td5hnMcKZPw
8️⃣ Linzess vs. Trulance: you’re watching it 😊
9️⃣ All About Viberzi: https://youtu.be/evoiw_wCsCU

😸 Check meowt on instagram: https://www.instagram.com/pelvicempowerment/

This video is the eighth installment of the IBS series and compares popular IBS-C drugs Linzess and Trulance.

Timestamps / Table of Contents:

✩ Intro: 0:00

✩ What Are Linzess & Trulance: 1:12
Linzess is linaclotide. Trulance is plecanatide. Both drugs belong to the same class—they are both guanylate cyclase-C agonists.

✩ How Do Linzess & Trulance Work: 2:27
Both Linzess and Trulance increase the amount of fluid in the intestines, which softens stool and increases intestinal transit time. They may help to decrease abdominal pain, but this has only been proven in non-human animal studies. Both drugs are meant to be taken daily. Linzess is taken on an empty stomach 30 minutes before eating. Trulance can be taken with or without food.
→ How Does Linzess Work? https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC40407
→ How Does Trulance Work? https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC60090

✩ History, Price, & Drug Interaction Considerations: 7:10
Linzess was the first approved guanylate cyclase-C agonist on the market in 2012. Trulance was approved in 2017. Both drugs cost around $500 for a 30 day supply and are usually not covered by insurance. Linzess has known drug interactions with: levothyroxine, bisacodyl, psyllium, magnesium hydroxide, and omeprazole. Trulance is known to interact with idelalisib.
→ History: https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC72130
→ Linzess Drug Interactions: https://dailymed.nlm.nih.gov/d....ailymed/drugInfo.cfm
→ Trulance Drug Interactions: https://dailymed.nlm.nih.gov/d....ailymed/drugInfo.cfm

✩ Side-Effects & Efficacy: 9:08
Both drugs may cause diarrhea, abdominal pain, bloating, and flatulence. Linzess may cause headaches. Both drugs are considered to be equally safe and effective in the literature.
→ Linzess Side-Effects: https://dailymed.nlm.nih.gov/d....ailymed/drugInfo.cfm
→ Trulance Side-Effects: https://dailymed.nlm.nih.gov/d....ailymed/drugInfo.cfm
→ Which Drug Is Better? https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC72130
→ Linzess Patient Reviews: https://www.everydayhealth.com..../drugs/linzess/revie & https://www.drugs.com/comments..../linaclotide/linzess
→ Trulance Patient Reviews: https://www.everydayhealth.com..../drugs/trulance/revi & https://www.drugs.com/comments..../plecanatide/trulanc

✩ Final Thoughts: 15:02

✩ Outro: 16:00

Remember, materials and content available in this channel, Pelvic Empowerment, are intended as general information only, and should not be substituted for medical advice, prescription, diagnosis, or treatment.

Read my full medical disclaimer, here: https://www.pelvicempowerment.com/disclaimer/

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