How does Zepbound (tirzepatide) compare to Wegovy (semaglutide)?

Fri, 15 Aug 2025 21:52:25 +0000

Tirzepatide (brand name: Zepbound) is the newest injectable medication for the treatment of adults with obesity, approved by the FDA on Nov 8, 2023.

Based on the results of the SURMOUNT trials, tirzepatide is the most effective obesity medication ever. This once-weekly injection produced an average weight loss of 20.9% of body weight at 72 weeks.

Prior to Zepbound, Wegovy (generic: semaglutide) was the most effective weight loss medicine, with an average weight loss of 15%.

In this video, Dr. Christopher McGowan, MD, MSCR, of True You Weight Loss, explains how tirzepatide (Mounjaro) works, and how it compares to Wegovy.