Side Effects of Metformin as a Life-Extension Drug

Fri, 15 Aug 2025 21:57:57 +0000

As a mild mitochondrial poison, metformin carries a variety of downsides. Taking it may have about a 1-in-67,000 chance of killing you every year.

This is the fourth video in a five-part series. If you missed any so far, see:
• Naturally Boosting AMPK with Caloric Restriction for Life Extension (https://nutritionfacts.org/vid....eo/naturally-boostin
• Naturally Boosting AMPK with Exercise for Life Extension (https://nutritionfacts.org/vid....eo/naturally-boostin
• Does Metformin Work as a Life-Extension Drug? (https://nutritionfacts.org/vid....eo/does-metformin-wo )

And stay tuned for The TAME Trial: Targeting Aging with Metformin (https://nutritionfacts.org/vid....eo/the-tame-trial-ta

AMPK is one of the anti-aging pathways I highlight in my longevity book, How Not to Age (https://nutritionfacts.org/book/how-not-to-age/), available in print, e-book, and audio. (All proceeds I receive from the book are donated directly to charity.)

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Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM

Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/

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