Everything You Need to Know About Bupropion (Wellbutrin Review, Bupropion Side-Effects, Uses, MOA)

Fri, 15 Aug 2025 21:58:53 +0000

Everything you need to know about bupropion is covered comprehensively in our thorough Wellbutrin review, which delves into bupropion side-effects, MOA, and more).
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This video is a comprehensive Wellbutrin review covering its indications, mechanism of action, everything you need to know about bupropion side-effects, and more. The FDA approved indications for Wellbutrin (bupropion) include major depressive disorder treatment, seasonal affective disorder medication, smoking cessation aid (marketed as Zyban), and weight loss when combined with naltrexone (Contrave) or dextromethorphan (Aplenzin).

As a norepinephrine and dopamine reuptake inhibitor (NDRI), Wellbutrin's mechanism of action involves inhibiting the reuptake of these neurotransmitters. Common Wellbutrin side-effects include dry mouth, nausea, headache, insomnia, and tremor. More serious potential bupropion side-effects are seizure risk, sjs (Stevens-Johnson syndrome), hypomania/mania, blood pressure elevation, and increased suicidal thoughts/behaviors in youth.

Important Wellbutrin drug interactions to consider include CYP2D6 inhibition affecting codeine, beta blockers, and atomoxetine metabolism. Caution is advised with MAOI combinations due to hypertensive crisis risk from increased catecholamines. Wellbutrin's active metabolites like hydroxybupropion contribute to its therapeutic effects. Overall, this comprehensive Wellbutrin medication review covers key aspects for prescribers.

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#depression #psychopharmacology #adhd

Chapters:
00:00 Psychofarm is a Perfect Place for Shade
00:09 It's not Buproprion
01:23 Indications
03:40 Formulations and History
09:09 Mechanism of Action
14:53 Side-effects
18:35 Metabolism / Metabolites
19:25 Drug drug Interactions
22:12 Outro