Rybelsus: Oral Ozempic? | Dr. Dan Obesity Expert

Tue, 26 Aug 2025 14:59:45 +0000

Have you heard of Oral Ozempic? It’s all over the news headlines as of late. Have you heard of Rybelsus? Same same, but different?

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A little while ago (okay, more like a year or two), I made a video comparing Ozempic to Rybelsus and talking about how it's kind of the inferior form of Ozempic. Is this still true?

Let’s get into it.

References:
▪️ Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, Rubino DM, Garvey WT; OASIS 1 Investigators. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jun 23:S0140-6736(23)01185-6. doi: 10.1016/S0140-6736(23)01185-6. Epub ahead of print. PMID: 37385278.
▪️ Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. PMID: 33567185.
▪️ Rodbard HW, Dougherty T, Taddei-Allen P. Efficacy of oral semaglutide: overview of the PIONEER clinical trial program and implications for managed care. Am J Manag Care. 2020 Dec;26(16 Suppl):S335-S343. doi: 10.37765/ajmc.2020.88554. PMID: 33439582.

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Related weight loss medication videos:
▪️ Rybelsus: Ozempic’s Least Favourite Sibling: https://youtu.be/-fo29OhgS10
▪️ Ozempic: The Game Changer: https://youtu.be/ilZ-Ls6VRQQ
▪️ Ozempic Paralyzed My Stomach: https://youtu.be/tj9thkkN5aM

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Video Topics: medication for weight loss injection, benefits of prescription weight loss, medication management, medical weight loss, weight management, weight loss medications, weight loss injections, obesity treatment, medically supervised weight loss, rybelsus, ozempic, oral ozempic, semaglutide