Comparing the Second Generation Hormone Therapies | Ask a Prostate Expert, Mark Scholz, MD

Fri, 29 Aug 2025 11:51:44 +0000

As of early 2021, the FDA has approved four second-generation anti-androgen mediations: Zytiga (abiraterone acetate), Xtandi (enzalutamide), Erleada (apalutamide), and Nubeqa (darolutamide). Here, Alex asks medical oncologist Mark Scholz, MD, how these medications work and how they compare to one another, especially regarding side effects.

0:05 How exactly do second-generation anti-androgens treat metastatic lesions?

1:33 What are the possible side effects of the four second-generation anti-androgens? How do they compare?

3:06 Are any of the four second-generation anti-androgens more appropriate than the others for men with heart problems?

3:56 What are some ways to mitigate the side effects of second-generation anti-androgen medications?

5:01 How do second-generation hormone therapies tend to affect PSA?

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