Vitamin B6 - Pyridoxine - Health effects, Vitamin B deficiency, Foods containing Vitamin B6

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Pyridoxine is in the vitamin B family of vitamins. Pyridoxine has important and it is required by the body to make amino acids, carbohydrates, and lipids.
Pyridoxine is required more then 100 different enzyme production. Enzymes are essential for human metabolism.
Pyridoxine also have role in neurotransmitter synthesis.
When person has Vitamin B deficiency it can be manifested differently.
In some cases it is associated with seborrheic dermatitis, in blood tests, microcytic anemia,
Dental decay is common, also glossitis – inflammation of tongue.
Patient may have some neurological symptoms like: peripheral neuropathy, electroencephalographic abnormalities, depression, confusion or epileptiform convulsions.
Vitamin B6 deficiency causes Weakened immune function.

Foods rich with Vitamin B6 include:
Beef liver, Tuna, Salmon, Fortified cereals, Chickpeas, Poultry.
Some vegetables and fruits, especially dark leafy greens, bananas, papayas, oranges, and cantaloupe.

Vitamin B6 Deficiency is rare in Generally healthy population.
Most common causes of Vitamin B6 deficiency are:
Increased Alcohol intake, poor renal function, autoimmune diseases, or intake medications like: isoniazid, cycloserine and theophylline.
There are wide range of labeled indications of Vitamin B 6:
For example it has been used empirically to treat some conditions, including atopic dermatitis, dental caries, acute alcohol intoxication, autism, diabetic complications, Down syndrome, schizophrenia, Huntington chorea, and steroid-dependent asthma.
Research shows a decreased risk of colorectal cancer with increased B6 intake in humans.

Administration:
The administration of vitamin B6 can be both via oral and intravenous routes. Oral vitamin B6 is the most prevalent form available, while the intravenous form is useful in some special cases, such as malabsorption syndromes, anorexia, and in patients on parenteral nutrition.
Adverse effects:
The most known adverse effect of vitamin B6 supplementation is sensory neuropathy, but this pathology rarely occurs below toxic doses–which is 1 gram/day or more for adults.
Most supplements are much lower doses then toxic dosage.
Other mild side effects can be: indigestion, nausea, breast tenderness, and in rare cases: photosensitivity, and vesicular dermatoses.

There are no reported adverse effects caused by dietary concentrations nor by regular supplemental doses of vitamin B6, while higher doses below levels of toxicity may cause indigestion, nausea, breast tenderness, photosensitivity, and vesicular dermatoses.

FDA
There are only two FDA-approved drugs containing pyridoxine or its analogs; the first is a combination of several vitamins, including B6, indicated for the prevention of vitamin deficiency in pediatric and adult patients, who are on parenteral nutrition .
and the second is a combination of doxylamine succinate and pyridoxine hydrochloride (a vitamin B6 analog), treatment of nausea and vomiting of pregnancy that does not respond to conservative management.
By Amras666 - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/....w/index.php?curid=40
By Prof. Osaro Erhabor - Prof. Osaro Erhabor, CC0, https://commons.wikimedia.org/....w/index.php?curid=36

By Sanjay Acharya - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/....w/index.php?curid=31

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