Quetiapine Side Effects

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How to use Quetiapine? (Seroquel) - Doctor Explains Side Effects 1 Views • 24 days ago

In this video we will cover everything you need to know about Quetiapine, also known as Seroquel. This video is part of a video series on mental health problems. So for more mental health related videos check out this playlist:
https://www.youtube.com/playli....st?list=PLaG3Bo3L0gX

Generic name: Quetiapine.
Brand names: Seroquel.
Available as a tablet and modified-release tablet.

How to use it?
Swallow the tablet completely with half a glass of water. Do not break them and don’t chew on them, as this might lower the effectivity of the tablet.
In addition Quetiapine should not be taken with food, as this can also decrease its effectivity. Therefore take it at least 1 hour before a meal.

Duration of treatment:
The duration of treatment depends on the indication of use and the severity of your symptoms. If your symptoms improve with the use of Quetiapine you usually have to keep using it for 12-24 more months. And sometimes multiple years.

When to use it?
Quetiapine is part of a group of drugs called antipsychotics. It can be used to treat several mental health conditions:
- Schizophrenia.
- Manic or depressive episodes in bipolar disorder.
- Severe depressive episode

What is the correct dosage?
Unfortunately I can’t provide you with guidelines for the correct dosages, as these differ a lot depending on the specific indication, the side effects you experience and the severity of your complaints.
Usually your doctor starts with a low dose and quickly builds it up over a few days. Afterwards your maintenance dose will be adapted throughout your treatment based on the blood levels of quetiapine you will be having.
Therefore always use the prescribed dose and frequency your doctor gave you.

What are the side-effects?
- Very common (more than 10%): drowsiness, dry mouth, dizziness, headache, muscle cramps and weight gain.
- Common (1-10%): increased appetite, nightmares, suicidal thoughts, irritation, blurred vision, shortness of breath, fast heart rate, palpitations, vomiting and changes in your blood values.
- Uncommon (0.1-1%): hypersensitivity, diabetes, restless legs and sexual dysfunction.

Safety:
- You should not eat or drink grapefruit juice, as this might increase the side effects you are experience.
- Furthermore be careful when you combine Quetiapine with alcohol. As this might increase the dazing effect of quetiapine.
- In addition it is usually safe to drive while using this drug, however it can cause you to become drowsy, sleepy and/or dizzy. If you experiencing any of these side effects then please do not drive.
- Lastly, Quetiapine can have interactions with several drugs. Therefore always discuss this with your treating physician.

Pregnancy and Lactation:
Quetiapine can be dangerous in both cases, especially for pregnant women and their unborn babies. However there are some exceptions.Therefore always discuss this with your prescribing doctor.

- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -

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Literature:
1: Farmacotherapeutisch Kompas. (2020). Quetiapine
2: Apotheek.nl (2020). Quetiapine.

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Which Antipsychotics Cause The Most Weight Gain? Side Effects 0 Views • 24 days ago

Antipsychotic medications are powerful drugs that are used to treat more than psychotic conditions like schizophrenia. Many of them are FDA-approved to treat bipolar disorder and depression. Even though they work very well and fast, they have some big side effects like weight gain and insulin resistance, some more than others. A new research study has given us some insight on which ones are better and worse.

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References
Shymko G, Grace T, Jolly N, et al. Weight gain and metabolic screening in young people with early psychosis on long acting injectable antipsychotic medication (aripiprazole vs paliperidone). Early Interv Psychiatry. 2021;15(4):787–793

Højlund M, Lund LC, Andersen K, Correll CU, Hallas J. Association of Low-Dose Quetiapine and Diabetes. JAMA Netw Open. 2021;4(5):e213209. doi:10.1001/jamanetworkopen.2021.3209

Holt RIG. Association Between Antipsychotic Medication Use and Diabetes. Curr Diab Rep. 2019 Sep 2;19(10):96. doi: 10.1007/s11892-019-1220-8. PMID: 31478094; PMCID: PMC6718373.

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Seroquel for sleep explained: unwanted actions, risk and alternatives Side Effects 0 Views • 24 days ago

Seroquel (quetiapine) is commonly used at low dose (Seroquel 25 mg or seroquel 50 mg) to help sleep, but new evidence suggests that it's a problem with increased cardiovascular mortality over time. Seroquel side effects can be long term.

We compare mechanism of quetiapine/Seroquel with olanzapine/zyprexa, clonidine/catapress, promethazine, Doxylamine, tricyclics and mirtazepine/avanza.

Seroquel side effects: The way quetiapine helps sleep is by blocking the histamine (H1) receptor in the brain. Histamine in the brain promotes wakefulness, so an antihistamine interferes with the wakefulness drive. But Seroquel also also affects the Dopamine receptor (D2 receptor), potentially dampening positive emotion (undesirable). Seroquel affects the serotonin 5HT2a receptor, potentially resulting in less flexible thinking (opposite to the effect of psychedelics) and the 5HT1a receptor which probably reduces sensitivity (potentially desirable unless numbing emotional ensues).

People often report carb hunger and weight gain which may be a contributor to type 2 diabetes and cardiovascular risk (may be a result of M3 receptor effect in insulin).

The metabolite of quetiapine (norquetiapine) is a potent Noradrenaline Reuptake Inhibitor (NET), which may contribute to increased arousal (usually undesirable in sleep).

So it may act to simultaneously reduce wakefulness and increase arousal.

Also quetiapine seems to cause significantly higher cardiovascular mortality (death) with long term use (summary here: https://www.facebook.com/photo/?fbid=801099334518256&set=a.756502285644628).

So if you are taking it at low dose for sleep, it might be worth talking to your doctor about alternatives such as simple antihistamines. Lipophilic (fat soluble) antihistamines (eg promethazine or doxylamine) block CNS H1 receptors which reduces wakefulness without all the other receptor effects. But they may have other harmful long term effects.

But better then meds long term is a Skills Before Pills approach: https://[a]www.thepsychcollective.com%2Fsleep[/a]

In particular we advocate the following to clear the thoughts out of your head before bed: https://www.youtube.com/watch?v=8zg_bvUJk5k

Here's a detailed blog: https://[a]www.thepsychcollective.com%2Fis-seroquel-for-sleep-slowly-killing-you[/a]

Here’s a handout with the table:
https://[a]www.thepsychcollective.com%2Fresources%2FSleep-and-Quetiapine-Seroquel-Handout-p601655357[/a]

There is concern about long term use of anticholinergic medications such as antihistamines that was not explored in this video.

This video is not medical advice and is based on mechanism, research data and anecdotes. Seek advise from a treating medical professional, do not act on the basis of this information.
No doctor-patient relationship formed.

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Not medical advice. The utility of any drugs for sleep in the long term need to be weighed up against the costs of long term use. Not all costs of long term use are well understood and different people have different risks/susceptibilities. Talk to your doctor about any treatments and any concerns about treatments.
----------------------

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#seroquel #sleep #skillsbeforepills
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2-Minute Neuroscience: Antipsychotics Side Effects 0 Views • 24 days ago

Antipsychotics are a class of drugs primarily used to manage the symptoms of psychosis; they are most commonly used to treat schizophrenia. In this video, I discuss first generation (e.g., chlorpromazine, haloperidol) and second generation (e.g., risperidone, quetiapine) antipsychotics, covering their mechanisms and side effects. I also briefly discuss xanomeline-trospium, a new addition to the antipsychotic market.

Learn more on my website: https://neuroscientificallychallenged.com

WATCH MORE
https://youtube.com/playlist?list=PLNZqyJnsvdMpkVaovOst1bKxaNgBCsTBK&si=HrZJJYzq1mcPrxKr

TRANSCRIPT

Antipsychotics are a class of drugs primarily used to manage the symptoms of psychosis. They are most commonly used to treat schizophrenia, but have indications for the treatment of several conditions.

There are many different antipsychotic medications, and although there are some variations in their mechanisms, almost all antipsychotics decrease dopamine activity, which is thought to be effective because increased dopamine activity may contribute to the symptoms of psychosis.

The first antipsychotics discovered, which are sometimes referred to as first generation antipsychotics, include drugs such as chlorpromazine and haloperidol. Their primary mechanism of action is to act as antagonists at a type of dopamine receptor called the D2 receptor, which means they block activity at these receptors and thus reduce dopamine signaling overall.

A more recently developed group of drugs is sometimes called second generation antipsychotics. These include risperidone, quetiapine, and others. Although drugs in this class have more varied mechanisms, most block dopamine and serotonin receptor subtypes. This serotonin receptor antagonism may be beneficial both for its direct effects on psychotic symptoms and because of serotonin’s role in modulating dopamine release, which might influence symptoms and reduce side effects caused by dopamine antagonism. Other drugs in this class have slightly different mechanisms at dopamine and serotonin receptors as well as actions at other neurotransmitter receptors.

Recently, a new drug called xanomeline was developed; it primarily stimulates acetylcholine receptors, giving it a unique mechanism among antipsychotics.

Antipsychotics are generally associated with movement-related side effects, such as Parkinsonism. The risk of significant movement-related side effects is lower with second generation drugs, but it is still present. Other problematic side effects include weight gain, an increased risk of diabetes, and cardiovascular complications. While these cardiometabolic side effects can occur with any antipsychotic, they are more strongly linked to second generation drugs.

REFERENCES

Brannan SK, Sawchak S, Miller AC, Lieberman JA, Paul SM, Breier A. Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia. N Engl J Med. 2021 Feb 25;384(8):717-726. doi: 10.1056/NEJMoa2017015. PMID: 33626254; PMCID: PMC7610870.

Chen, A., Nasrallah, H.A. (2018). Antipsychotics. In: Grossberg, G., Kinsella, L. (eds) Clinical Psychopharmacology for Neurologists. Springer, Cham. https://doi-org.ezaccess.libra....ries.psu.edu/10.1007

Lally J, MacCabe JH. Antipsychotic medication in schizophrenia: a review. Br Med Bull. 2015 Jun;114(1):169-79. doi: 10.1093/bmb/ldv017. Epub 2015 May 8. PMID: 25957394.

Leucht S, Priller J, Davis JM. Antipsychotic Drugs: A Concise Review of History, Classification, Indications, Mechanism, Efficacy, Side Effects, Dosing, and Clinical Application. Am J Psychiatry. 2024 Oct 1;181(10):865-878. doi: 10.1176/appi.ajp.20240738. PMID: 39350614.

Meltzer HY, Massey BW. The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr Opin Pharmacol. 2011 Feb;11(1):59-67. doi: 10.1016/j.coph.2011.02.007. Epub 2011 Mar 21. PMID: 21420906.

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Top 11 Questions about Seroquel Withdrawal, Side Effects, and Tapering Side Effects 0 Views • 24 days ago

Looking to learn the risks compared to rewards of taking Seroquel? In this video, the founder of Alternative to Meds Center, Lyle Murphy, answers the Top 11 questions about Seroquel Withdrawal, Side Effects, alternatives and Tapering.

Top 11 questions about Seroquel Withdrawal

00:00 - Intro
00:07 - Why do people get prescribed Seroquel?
00:31 - Is Quetiapine a narcotic?
00:56 - What are the side effects of Seroquel?
02:02 - Does Seroquel help with anxiety?
02:38 - Is Seroquel dangerous?
05:55 - What are the long term effects of taking Seroquel?
07:06 - Is Seroquel a good sleep aid?
07:57 - Is Seroquel bad for your liver?
09:05 - Is Seroquel stronger than Xanax?
10:40 - Is Trazodone stronger than Seroquel?
11:12 - How is Seroquel being abused?
11:56 - ATMC

For more information about Seroquel Withdrawal, Tapering Seroquel, Seroquel Side Effects, or Seroquel Alternatives visit:
https://www.alternativetomeds.....com/antipsychotics/s

Seroquel (quetiapine) is an atypical antipsychotic medication FDA approved for the treatment of schizophrenia and mixed bipolar episodes in adults or used off-label for children over the age of 12.

It is also used for episodes of acute mania, depression disorders in adults and in children 10 years old and up. It is often used as an augmenter with antidepressant medications for treating depressive disorders.

There are several off-label uses for Seroquel which are being explored but remain outside of FDA approval, such as for insomnia, the treatment of dementia, addiction, delirium, and personality disorders.

At present, these off-label uses are being cautiously examined due to a lack of established dosing parameters and their effects on metabolic side effects, extrapyramidal adverse effects and potential safety concerns.

Seroquel (Quetiapine) Withdrawal Symptoms
As is the case for most prescription psychoactive medications, using them for some extended period of time, i.e. several months or longer may lead to physical dependence. If the decision to come off the drug is made, stopping should never be done abruptly. Always seek medical oversight and guidance for safety.

Even when slowing the tapering off a drug, there can still be some significant withdrawals, which may be more severe if the prescription was for a very long time, such as years.

When withdrawing from Seroquel, the following symptoms may occur:

Suicidal ideation or behavior
Seroquel Withdrawal Psychosis
Mania
Insomnia
Hypersensitivity to light, sound, temperature, all sensory perceptions
Vomiting
Headaches
Racing heart, tachycardia
Unusual mood swings, can change rapidly
Slowed heartbeat
Nausea
Dizziness
Anxiety
Agitation
Loss of concentration, can’t focus
Depression

#seroquel #alternativetomeds #sideeffects #seroquelwithdrawal #mentalhealthawareness

Understanding The Long Term Side Effects Of Seroquel Side Effects 0 Views • 24 days ago

00:00 - Intro
00:22 - Can Long-Term Use Of Seroquel Cause Permanent Brain Damage?
03:25 - Is Seroquel Good For Long-Term Use?
04:14 - Does Quetiapine (Seroquel) Shorten Your Life?
04:28 - Does Seroquel Cause Memory Loss?
04:50 - What Is A Good Replacement For Seroquel?
07:20 - Can You Build Up A Tolerance To Seroquel?
08:04 - Does Seroquel Affect The Liver?
08:34 - Is Seroquel Habit-Forming?
09:45 - Is Seroquel Hard On The Kidneys?
09:58 - What Happens When You Stop Taking Seroquel?
11:04 - What Does Seroquel Do To The Brain?
11:46 - Outro

Is Seroquel Good for Long-Term Use?
While we do not yet know the full extent of Seroquel’s long-term effects, some of the research so far has been concerning to psychiatrists and health advocates. While the initial trials that were used to approve Seroquel for the treatment of schizophrenia demonstrated fairly consistent tolerance and efficacy, the studies into long-term use so far have had more mixed to disastrous results.

Some of the most common side effects emerging among long-term quetiapine patients include muscle issues. The side effects reported range from simple annoyances like stiff muscles to debilitating conditions like constant involuntary movement in the mouth.
Some of the most common side effects emerging among long-term quetiapine patients include muscle issues. The side effects reported range from simple annoyances like stiff muscles to debilitating conditions like constant involuntary movement in the mouth.

The muscle problems related to long-term Seroquel treatment can be divided into two categories, the first being extrapyramidal symptoms (EPS) and the other being tardive dyskinesia (TD). EPS manifests as muscles that are restless, prone to involuntary trembling, and frequently feel stiff. TD results in slow muscle response and awkward, difficult-to-control movements. The first symptoms of TD often manifest in small, involuntary movements in the muscles in the mouth, jaw, and tongue.

What Does Quetiapine Do to the Brain?
In short, we don’t know exactly how Seroquel works on the brain. We know that using Seroquel produces a sedative effect that can help resolve serious schizophrenic episodes where someone is at risk of harming themselves and others, but we don’t know if relying too heavily on Seroquel over time might be doing more harm than good to the patient’s brain and body.
Read More Here: https://www.alternativetomeds.....com/blog/risks-seroq

Studies Mentioned :

Joanna Moncrieff
https://joannamoncrieff.com/20....13/12/13/antipsychot

Martin Harrow
https://academic.oup.com/schiz....ophreniabulletin/art

Journal Of Nervous And Mental Diseases
https://www.theguardian.com/co....mmentisfree/2008/mar

Abram Hoffer and Humphrey Osmond
https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC72173

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https://pubmed.ncbi.nlm.nih.gov/12172332/

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Seroquel side effects : What YOU need to know! Side Effects 0 Views • 24 days ago

This video looks at Seroquel side effects, uses and doses.Seroquel is an anti-psychotic drug to treat schizophrenia, bipolar disorder, depression and treatment resistant OCD.The brand name is Quetiapine.

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Read entire transcript here: https://drthinkyourhealth.com/....seroquel-side-effect

⏰TIMESTAMPS:

00:00 Intro
00:28 What is Seroquel?
00:41 What is Seroquel used for?
01:15 How is Seroquel taken?
02:09 How does Seroquel work?
02:26 Seroquel side effects?
07: 10 TIPS before taking Seroquel?

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Sources:

1) https://www.accessdata.fda.gov..../drugsatfda_docs/lab
2) https://www.goodrx.com/quetiapine/what-is
3) https://www.rxlist.com/seroquel-drug.htm

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#Seroquel # quetiapine