Sulfasalazine Side Effects

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Mechanism of Action of Aminosalicylates Side Effects 1 Views • 15 days ago

Developed and produced for http://www.MDPracticeGuide.com, a CME resource for physicians and healthcare providers.

Animation Description: This animation explains the mechanism of action of aminosalicylates used for the treatment of inflammatory bowel disease (IBD).

Aminosalicylates include sulfasalazine and 5-aminosalicylic acid (5-ASA).

Sulfasalazine, a sulfa drug, inhibits folic acid synthesis. As such, folic acid supplements should be taken with sulfasalazine to reduce the risk of neural tube defects.

Sulfasalazine exhibits anti-inflammatory properties when split by gut bacterium into its metabolites: sulfapyridine and 5-ASA (mesalamine).

The anti-inflammatory benefits of sulfasalazine, are chiefly derived from 5-ASA, which has fewer side effects than sulfapyridine. As such, administration of 5-ASA alone may be preferred over sulfasalazine.

5-ASA is poorly absorbed by the intestines and systemic circulation, thus most remains in the terminal ileum and colon or is passed in the stool. 5-ASA within the lumen primarily exhibits a topical effect on the colonic epithelium.

Absorbed 5-ASA is extensively metabolized to N-acetyl-5-ASA by N-acetyltransferase 1 (NAT1). N-acetyl-5-ASA then binds PPAR-gamma (peroxisome proliferator-activated receptor gamma) a nuclear hormone receptor.

Binding of N-acetyl-5-ASA induces the translocation of PPAR-gamma from the cytoplasm to the cell nucleus and a conformational change in PPAR-gamma.

This modification permits the recruitment of the co-activator, vitamin D3 receptor-interacting protein (DRIP), which interacts directly with PPAR-gamma.

Heterodimerization with the retinoid X receptor (RXR) occurs, resulting in formation of the PPAR-RXR complex, a transcriptional regulator.

The PPAR-RXR heterodimer controls transcription by binding a regulatory PPAR-gamma response element (PPRE) and modulating the expression of genes involved in the inflammation process.

PPAR-RXR downregulates the nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) to reduce production of pro-inflammatory cytokines.

This complex also reduces COX-2 activity, leading to a reduction in prostaglandins involved in inflammation.

Novel agents with similar mechanisms to 5-ASA, but which target PPAR-gamma more efficiently and report a reduction of adverse events, are currently under investigation.

For example the compound, GED-0507-34, exhibits a 100- to 150-fold greater anti-inflammatory effect than 5-ASA.

A new generation of 5-ASA, balsalazide, is able to bypass the small intestine and release a high concentration of 5-ASA in the colon.

Is Sulfasalazine Used To Treat Rheumatoid Arthritis? - Orthopedic Support Network Side Effects 1 Views • 15 days ago

Is Sulfasalazine Used To Treat Rheumatoid Arthritis? In this informative video, we'll discuss the role of sulfasalazine in managing rheumatoid arthritis. Sulfasalazine is a disease-modifying anti-rheumatic drug that helps address the underlying factors of this condition rather than just alleviating the symptoms. We will cover how this medication reduces inflammation, pain, and swelling in the joints, which is essential for preserving joint function over time.

You'll learn about the typical process for starting sulfasalazine, including the initial dosing and how doctors gradually adjust it to ensure patient tolerance. We’ll also touch on the importance of monitoring during treatment, including the necessary blood tests to check for potential side effects. This medication can be used alone or in combination with others, such as methotrexate or hydroxychloroquine, to achieve better control of symptoms.

Understanding the use of sulfasalazine is important for anyone affected by rheumatoid arthritis, whether you are a patient, caregiver, or simply interested in orthopedics. Join us in this discussion, and don't forget to subscribe for more helpful information on managing orthopedic conditions and medications.

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#RheumatoidArthritis #Sulfasalazine #Orthopedics #JointHealth #AntiRheumaticDrugs #Inflammation #PainManagement #MedicationManagement #PatientCare #HealthMonitoring #ChronicIllness #AutoimmuneDisease #JointFunction #DiseaseModification #OrthopedicCare

About Us: Welcome to the Orthopedic Support Network, your go-to resource for all things orthopedic! Our channel is dedicated to empowering individuals with information about orthopedic health, treatments, and innovations. Whether you're dealing with joint pain, recovering from surgery, or simply looking to enhance your physical well-being, we cover a range of topics including injury prevention, rehabilitation exercises, and expert interviews with leading orthopedic specialists. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

What Are The Common Hydroxychloroquine Side Effects To Know Side Effects 0 Views • 15 days ago

All You Need to Know about Hydroxychloroquine / Plaquenil
What Are The Common Hydroxychloroquine or Plaquenil Side Effects To Know
In this video, I answer 10 crucial questions about a Hydroxychloroquine, also known as Plaquenil, a medication used for patients with arthritis like RA, Lupus or Sjogren’s Disease.
#hydroxychloroquine #plaquenil #rheumatoidarthritis
#lupus #sjogrenssyndrome #sjogrens #dermatomyositis

Chapters
0:00 - 0:36 Intro
0:37 - 1:15 What is Hydroxychloroquine/Plaquenil?
1:16 - 1:42 Effect of Hydroxychloroquine in Rheumatoid Arthritis Patients
1:43 - 2:15 Is Hydroxychloroquine a pill or an injectable medication?
2:16 - 3:01 Plaquenil / Hydroxychloroquine most common side effects
3:02 - 3:28 Can Hydroxychloroquine be combined with other medications?
3:29 - 4:31 How common is Hydroxychloroquine to affect the eyes?
4:32 - 5:18 How to monitor if Hydroxychloroquine is safe for my body?
5:19 - 6:01Can Hydroxychloroquine affect my organs?
6:02 - 6:35 Can I get vaccinated while taking Hydroxychloroquine?
6:36 - 7:54 Is Hydroxychloroquine safe for pregnancy and breastfeeding?

Rheumatoid Arthritis Journal: https://amzn.to/4btmUZC

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👩🏻‍⚕️ About Me: Dr. Diana Girnita is a distinguished, double board-certified physician specializing in Rheumatology and Internal Medicine. Holding a Ph.D. in Immunology and having completed rigorous training at Harvard and other top-tier institutions, her expertise in rheumatology is unparalleled.

🎓🏥🔬 Rheumatologist OnCall, a pioneering platform offering cutting-edge, integrative rheumatology care to democratize access to specialized healthcare.
🌐🎯 Dr. Girnita's unique focus on Rheumatoid Arthritis (RA) allows for personalized, multi-disciplinary treatment plans beyond pharmacotherapy. Integrating nutrition 🥦, physical activity 🏋️‍♀️, and stress management techniques 🧘‍♀️, Dr. Girnita aims to empower her patients to live fuller, healthier lives.

🌱⚠️ Disclaimer: This video and its content are for general informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Views expressed in comments are those of the individuals and do not reflect the opinion of Rheumatologist OnCall.

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What Are Sulfasalazine's Side Effects? - Sensitive Stomach Guide Side Effects 1 Views • 15 days ago

What Are Sulfasalazine's Side Effects? In this informative video, we will discuss the side effects associated with Sulfasalazine, a medication commonly prescribed for inflammatory bowel diseases like ulcerative colitis. Understanding these side effects is important for anyone dealing with conditions such as irritable bowel syndrome or colitis. We will cover the common digestive issues that may arise, including symptoms like indigestion, heartburn, nausea, and diarrhea, which can complicate managing your condition. Additionally, we will touch on other potential side effects that could affect your overall health, including headaches and dizziness.

It's essential to be aware of the serious reactions that can occur with Sulfasalazine. We will outline signs that require immediate medical attention, such as allergic reactions and liver damage. Recognizing these symptoms can help you take timely action and ensure your safety while using this medication.

If Sulfasalazine doesn't suit you, we will also mention alternative medications that may be more tolerable. Join us as we navigate through the important aspects of Sulfasalazine side effects, and remember to communicate with your healthcare provider about your experiences. Subscribe to our channel for more helpful information on managing digestive health.

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#Sulfasalazine #IBD #Colitis #IBS #DigestiveHealth #MedicationSideEffects #InflammatoryBowelDisease #HealthAwareness #PatientEducation #DigestiveDiscomfort #AllergicReactions #LiverHealth #MedicationManagement #ChronicIllness #HealthcareProvider

About Us: Welcome to Sensitive Stomach Guide! Our channel is dedicated to helping individuals navigate the challenges of digestive health. We cover a wide range of topics including Irritable Bowel Syndrome (IBS), IBS symptoms and triggers, the sensitive stomach diet, Inflammatory Bowel Disease (IBD), ulcerative colitis, Crohn’s disease, gut health tips, the low FODMAP diet, and managing bloating and gas, along with natural remedies for digestive issues. We aim to create a friendly and informative space where you can find support and practical advice tailored to your needs. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Does Sulfasalazine Cause Weight Gain? - Orthopedic Support Network Side Effects 2 Views • 15 days ago

Does Sulfasalazine Cause Weight Gain? In this informative video, we discuss the effects of sulfasalazine, a medication commonly prescribed for rheumatoid arthritis. This drug is part of a group known as disease-modifying antirheumatic drugs, which aim to reduce inflammation and slow the progression of arthritis. While managing symptoms is essential for those living with arthritis, understanding the potential side effects of medications is equally important.

We will cover how sulfasalazine interacts with the body and what patients might expect while taking it. Many individuals may experience gastrointestinal side effects, which can impact their overall health. We’ll also provide tips on how to manage these side effects effectively, including dietary adjustments that can help alleviate discomfort.

It's vital for patients to monitor their health and communicate any changes to their healthcare provider. This video will guide you through the process of ensuring that your treatment for arthritis is both effective and supportive of your overall well-being. Join us for this essential discussion, and don’t forget to subscribe to our channel for more helpful information on orthopedics and medication management.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@Ortho....pedicSupportNetwork/

#Sulfasalazine #WeightGain #RheumatoidArthritis #MedicationSideEffects #GastrointestinalIssues #HealthManagement #ArthritisTreatment #DiseaseModifyingDrugs #PatientCare #DietaryAdjustments #HealthcareTips #MedicationAwareness #JointHealth #WellnessJourney #Orthopedics

About Us: Welcome to the Orthopedic Support Network, your go-to resource for all things orthopedic! Our channel is dedicated to empowering individuals with information about orthopedic health, treatments, and innovations. Whether you're dealing with joint pain, recovering from surgery, or simply looking to enhance your physical well-being, we cover a range of topics including injury prevention, rehabilitation exercises, and expert interviews with leading orthopedic specialists. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

SULFASALAZINE - - - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 1 Views • 15 days ago

NEW MEDICATION?! | SULFASALAZINE Side Effects 0 Views • 15 days ago

I have a diagnosis of two auto-immune diseases; Ankylosing Spondylitis (AS) and Inflammatory Bowel Disease (IBD). In this video I talk about a new medication I have just started; Sulfasalazine. Sulfasalazine is a Disease Modifying Anti-Rheumatic Drug (DMARD). It’s the first DMARD I have ever been on to treat my auto-immune conditions.

DISCLAIMER: I am not a DR or a qualified health professional. I am making these videos as a patient blogging about my experience of living with these diseases in an attempt to help others living with similar diseases. I am not attempting to give medical advice - just to share my story.

I recently filmed a video where I discussed a new diagnosis (IBD). I’ll link this below and in the description box.

HERE IS THE LINK: https://youtu.be/LK2skQm-wdU

Sulfasalazine a Milder DMARD than some others. Can be used alone or in combination of other DMARDs. Reduces joint pain, swelling stiffness. I’m currently taking Sulfasalazine alongside a medication which I was on beforehand called Celecoxib.

Celecoxib belongs to a different group of drugs called Non Steriodal Anti-Inflammatory Drugs (NSAIDs). I’ll link below a video where I explain how NSAIDs work in more detail.

HERE IS THE LINK: https://youtu.be/H0iNYFg39_I

As I said I’m still taking Celecoxib. This is because Sulfasalazine is a slow-acting drug. Patients typically start to notice a benefit after 6-8 weeks although it can take up to 6 months before people feel the full effects of the Sulfasalazine.

Sulfasalazine also belongs to a group of drugs called Sulfonamides (sulfa-drugs). These are drugs that are derived from sulfanilamide, a sulfur-containing chemical. Most sulfonamides are antibiotics, but some are prescribed for treating rheumatic conditions or IBD, such as Sulfasalazine.

There are quite a few possible side-effects that people can develop on Sulfasalazine - because of this the dosage of medication is built up over time. I took 500mg once a day for two weeks, before increasing to two 500mg tablets a day. Some people may continue to increase their dosage over time (most people wouldn’t be on more than 4000mg a day, depending on the condition they are taking it for). (1)

Side effects:
- Some people are allergic to sulfa-based drugs and may come out in a rash or have another allergic reaction. My rheumatologist advised me to stop taking the medication immediately if this happens.
- As I said Sulfasalazine is a DMARD. Part of the way that DMARDs work is by suppressing the immune system. This means that the inflammation levels in the body are lowered and inflammatory auto-immune conditions can be treated; but it can also make people more susceptible to getting ill as the immune system may not be functioning as efficiently. It can also reduce white blood cell count. Because of this, when I’m first starting this medication, I have to get regular blood tests to check inflammatory markers in the body, blood cell counts and liver and kidney function.
- One side effect that I definitely noticed when I first started taking Sulfasalazine is that I developed quite a few mouth ulcers. This was obviously a little bit sore but it seemed to begin to even out after a couple of weeks.
- Another common side effect of Sulfasalazine is nausea. Made me nauseous when I first started taking it, although no vomiting - just reduced appetite. This is slightly better now.
- Sulfasalazine can cause a fever in reaction to the drug. This is sometimes called a ‘drug fever’. I haven’t felt unwell since I have started taking Sulfasalazine, but I have had a persistent high temperature (normally sitting around 38 whenever I’ve taken it). This is something I will be asking my rheumatologist about when I next see him.
- Colour of urine - mine has become a bright yellow / orange colour. This is a normal side effect and nothing to worry about.

There are lots of possible side effects but I’m only going to talk about the ones that I have noticed myself. Medication reacts to every different person differently so please do your research before you begin a new medication and talk to your DRs if you are worried about any possible side effects.

Because Sulfasalazine is a slow acting drug, I haven’t really noticed many benefits yet - but that’s to be expected because I’ve not even been on it a month yet and it can take 6-8 weeks for most people to begin to notice a difference. I’ll try and film an update after I’ve been on it a little longer to talk about the changes I’ve noticed. At the moment I’’m just trusting in the process and taking it in good faith.

Hope you enjoyed the video guys! Please comment below if you also take Sulfasalazine and let me know how you find it! I love reading all your comments and try and reply to each and every one.

Lots of love!
Izzy xxx

REF:
1. https://www.mayoclinic.org/dru....gs-supplements/sulfa