Dutasteride Side Effects

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Doctor Reviews XYON Health Topical Dutasteride Side Effects 1 Views • 2 months ago

In this must-watch video, Dr. Asi Peretz dives deep into the world of topical finasteride and dutasteride. Collaborating with the innovative brand Xyon, Dr. Asi talks about the groundbreaking advancements in their updated topical treatments.
-Learn about the benefits, potential side effects, and see the latest data and tests that make this product a game changer in hair restoration. Whether you're considering treatment or just curious, this video provides crucial insights into the future of hair loss solutions.

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⏰ Timecodes ⏰
0:00 - Introduction
0:36 - Side Effects
1:41 - Overview of Finasteride & Dutasteride Topicals
3:11 - Data Testing and Results
8:29 - Dr. Asi’s Criticism & Insights
9:04 - Conclusion!

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Trichogenics Hair Restoration Clinic! We specialize in providing expert advice, treatments, and solutions for all your hair restoration needs. On our channel, you'll find valuable insights and information about hair transplants, scalp health, and much more. Subscribe and join our community to stay updated with the latest in hair restoration.

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The truth about dutasteride’s side effects Side Effects 1 Views • 2 months ago

Linked videos:
Truth about finasteride's side effects: https://youtu.be/rNwlasPw4WI
Optimal dose of finasteride: https://youtu.be/15PHO1m6D-c
Perfect dose of dutasteride: https://youtu.be/wdSlHnSRi7g
Mic the Vegan: https://youtu.be/tPoUJ17_jxU
Long term finasteride results: https://youtu.be/8D-UJ4EsZZg
Why do hair loss treatments cause shedding? https://youtu.be/VxVYHP0WNfA

Sources:
1. Drake L, Unger WP. The effects of f’masteride on scalp skin and serum androgen levels in men with androgenetic alopecia. Published online 1999:5.
2. Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor. The Journal of Clinical Endocrinology & Metabolism. 2004;89(5):2179-2184. doi:10.1210/jc.2003-030330
3. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. Journal of the American Academy of Dermatology. 2006;55(6):1014-1023. doi:10.1016/j.jaad.2006.05.007
4. Nickel JC, Gilling P, Tammela TL, Morrill B, Wilson TH, Rittmaster RS. Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: the Enlarged Prostate International Comparator Study (EPICS). BJU International. 2011;108(3):388-394. doi:10.1111/j.1464-410X.2011.10195.x
5. Kaplan SA, Chung DE, Lee RK, Scofield S, Te AE. A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride. Int J Clin Pract. 2012;66(11):1052-1055. doi:10.1111/j.1742-1241.2012.03010.x
6. Gubelin Harcha W, Barboza Martínez J, Tsai TF, et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. Journal of the American Academy of Dermatology. 2014;70(3):489-498.e3. doi:10.1016/j.jaad.2013.10.049
7. Shanshanwal SJS, Dhurat RS. Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study. Indian J Dermatol Venereol Leprol. 2017;83(1):47-54. doi:10.4103/0378-6323.188652
8. Lee S, Lee YB, Choe SJ, Lee WS. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Acta Derm Venereol. 2019;99(1):12-17. doi:10.2340/00015555-3035
9. Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clin Interv Aging. 2019;14:399-406. doi:10.2147/CIA.S192435
10. Zhou Z, Cui Y, Wu J, Jin H. Efficacy and safety of dutasteride compared with finasteride in treating males with benign prostatic hyperplasia: A meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine. 2020;20(2):1566-1574. doi:10.3892/etm.2020.8851
11. Choi GS, Sim WY, Kang H, et al. Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study. Annals of Dermatology. 2022;34(5):349-359. doi:10.5021/ad.22.027
12. Laanani M, Weill A, Jollant F, Zureik M, Dray-Spira R. Suicidal risk associated with finasteride versus dutasteride among men treated for benign prostatic hyperplasia: nationwide cohort study | Scientific Reports. Scientific Reports. 2023;13(1):5308. doi:10.1038/s41598-023-32356-3

Dutasteride VS Finasteride - Which Is BETTER For Your Hair Growth? Side Effects 0 Views • 2 months ago

WATCH NEXT - https://www.youtube.com/watch?v=BlPb46W0Fm4

Dutasteride or finasteride? Which is better? We have a detailed, point by point comparison coming right up. And in the end, we’re gonna give you our verdict. There is a winner, and you’ll find out who it is in today’s video.

Timestamps:
📌0:00 - Intro
📌1:05 - Mechanism of action
📌2:46 - Efficacy
📌4:42 - Side effects
📌6:02 - Price
📌6:35 - Availability
📌7:14 - Popularity
📌7:40 - The overall winner

Transcription:

Today we’ll be comparing finasteride to dutasteride across various domains, like their efficacy and side effects.

We’ll give you the winner in each area.

And in the end we’ll give you our verdict on the overall winner.

So let’s get into it.

Mechanism of action.

So both finasteride and dutasteride block DHT.

And they do this in a similar way: by inhibiting the enzyme that converts testosterone into DHT.

This enzyme is called five-alpha-reductase.

By inhibiting this enzyme, our body is unable to convert the circulating testosterone into DHT, and the levels of DHT drop.

Dramatically.

So both drugs are so-called 5-alpha-reductase inhibitors.

But there is a big difference between them.

There are versions of the 5-alpha-reductase enzyme.

These are simply called type 1 and type 2. They have a slightly different chemical structure but exactly the same function: they both convert testosterone to DHT.

Now finasteride only inhibits the type 2 enzyme.

Whereas dutasteride inhibits the type 1 and type 2.

And because our body makes DHT from both enzymes, dutasteride results in a near-total suppression of DHT levels, over 90%.

This compares to around 70% reduction from finasteride.

So, clearly, the winner here is dutasteride, right?

Well, actually no.

You see, it’s only the DHT made from the type 2 enzyme that causes hair loss.

We know this from a rare genetic mutation that makes some people lack a functional type 2 enzyme.

These people still have DHT in their system from the type 1 enzyme, but they’re immune to hair loss.

So even though dutasteride is the most efficient DHT blocker of the two, you judge a medication by its selectiveness, not by its potency.

If it’s only the type 2 enzyme that causes hair loss, the superior medication is the one that only blocks the type 2 enzyme, not both.

The more targeted the medication, and the less it interferes with other aspects of our biochemistry, the better.

WINNER: FINASTERIDE

Efficacy

So both drugs are efficient at blocking the progression of hair loss, at least for the majority of users.

There is so much research at this point that this is beyond doubt.

But which of the two is better? With which one are you more likely to regrow hair?

Now guys I want to be clear: the differences between the two drugs aren’t that large.

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Reference Links:
https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC63887
https://onlinelibrary.wiley.co....m/doi/pdf/10.1111/ij
https://www.sciencedirect.com/....science/article/abs/
https://youtu.be/RX1CwnJ1Zy0
https://youtu.be/dI3HeHzEGBk

Disclaimer
This video is for educational purposes only.