📖Topic Covered in this video:
✔️SYNTHESIS OF DIPHENHYDRAMINE
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Next up on the medications I'm going over Diphenhydramine or Benadryl and its role it plays as a treatment for allergic reactions and anaphylaxis. This video goes deeper into the pharmacology of how Benadryl works, beyond just how it's an Antihistamine.


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Study this First-gen Antihistamines mnemonic and other mnemonics with Pixorize.

First generation antihistamines are a class of drugs that include Chlorpheniramine and Diphenhydramine. These drugs work by blocking histamine receptors, muscarinic receptors, and alpha-1 adrenergic receptors. Blocking H1 histamine receptors can reduce histamine-mediated vasodilation and vascular permeability, helping to treat allergy symptoms. Blocking muscarinic receptors can help to treat vestibular nausea, or motion sickness. However, due to their multiple mechanisms, first generation antihistamines also cause a variety of side effects. As antimuscarinic drugs, these drugs can cause anticholinergic symptoms like dry mouth, constipation, confusion, and hallucinations. Blockade of alpha-1 receptors can lead to orthostatic hypotension, characterized by lightheadedness and dizziness. Finally, blockade of histamine receptors can lead to sedation or drowsiness by blocking inhibiting centers in the brain.

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How To Use Benadryl Antihistamine Allergy Tablets Review
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About this product:

Benadryl Antihistamine Allergy Tablets

100-count packs of Benadryl Ultratabs each containing 25 mg of the antihistamine diphenhydramine HCl for allergy relief that works when you need it most
Active ingredient, diphenhydramine HCl, provides relief for both allergy symptoms and cold symptoms like sneezing and runny nose
Works when you need it most with an allergy medicine in small, convenient antihistamine tablets that put your allergies to rest
Provides allergy medicine for sneezing; runny nose; itchy nose or throat; and itchy, watery eyes and cold symptoms like sneezing and runny nose
100 of tablets for multi-symptom allergy relief intended to be used by those ages six and up
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Thank you for watching Diphenhydramine in EMS!

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Diphenhydramine (Benadryl) is an antihistamine that’s often found in over-the-counter (OTC) allergy relief medications.

You can purchase OTC drugs at grocery stores, drug stores, and pharmacies without a prescription.

Although diphenhydramine is commonly used in OTC medications, it can also produce a high and even cause dependence.

The half-life of diphenhydramine determines how long its side effects last and how long it stays in a person’s body.

Additionally, factors like weight, age, and the dosage taken can also influence the results of a drug test.

So, how long does diphenhydramine stay in your system?

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Videoconsejo sanitario sobre Difenhidramina, para qué sirve este medicamento, cuándo y cómo debemos tomarla. Videoconsejo impartido por el farmacéutico Jorge Gómez-Carpintero, elaborado por el Consejo General de Colegios Farmacéuticos y producido por Medicina TV.

Difenhidramina es un fármaco del grupo de los antihistamínicos de primera generación, que bloquea los receptores H1 de la histamina y además presenta un marcado efecto sedante.

Debido a su mecanismo de acción, se encuentran disponibles medicamentos que contienen difenhidramina sola o en asociación con distintas indicaciones, como el tratamiento del insomnio ocasional, el alivio de la congestión o la tos asociadas a procesos alérgicos o catarrales y el alivio del picor de origen alérgico.

Para el tratamiento del insomnio, la dosis habitual en adultos es de un comprimido 50 mg de difenhidramina, y de 25 mg (medio comprimido) en niños mayores de 12 años, siempre bajo recomendación médica, entre 20 y 30 minutos antes de acostarse.

Cuando el insomnio está asociado a episodios dolorosos, difenhidramina se puede encontrar en asociación con paracetamol en comprimidos con una dosis de 25 mg.

Para el tratamiento de la tos, se utiliza en forma de solución oral junto con dextrometorfano, mientras que, para el tratamiento de la congestión nasal, difenhidramina puede encontrarse combinada con clorfeniramina.

Como tratamiento del picor o escozor de la piel de origen alérgico, difenhidramina se utiliza en forma de crema en adultos y niños mayores de 2 años. Se recomienda limitar el uso a un máximo de 5 días, y si los síntomas no mejoran consultar con el médico o el farmacéutico.

Cuando se utiliza por vía oral, los efectos adversos más frecuentes con difenhidramina son somnolencia, fatiga y mareo.

Cuando se utiliza aplicada sobre la piel, puede producir reacciones de sensibilidad cutánea y de fotosensibilidad, por lo que se debe reducir la exposición al sol durante el tratamiento.

Y recuerda, pregunta siempre a tu farmacéutico de confianza. Te informaremos sobre cómo debes utilizar difenhidramina y sobre cualquier otra duda que tengas.

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References:

The Pharmacology and Use of H1-Receptor-Antagonist. N Engl J Med 1994; 330:1663-1670

Advances in H1-Antihistamines. N Engl J Med 2004; 351:2203-2217

Cardiac arrest caused by diphenhydramine overdose. Acute Med Surg. 2018 Oct; 5(4): 380–383.

IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine. Am J Case Rep. 2019 May 29;20:758-763.

Diphenhydramine with Intraventricular Conduction Delay Treated with Hypertonic Sodium Bicarbonate and IV Lipid Emulsion. West J Emerg Med. 2014 Nov; 15(7): 855–858.

Diphenhydramine in a 26-year-old Woman. J Emerg Nurs. 2008 Dec;34(6):543-4.

The family of a 13-year-old boy who died after overdosing on Benadryl by attempting a TikTok challenge are warning other parents. https://abc7.com/what-is-tikto....k-benadryl-challenge

NCLEX Review: Diphenhydramine (Benadryl/Banophen) - Uses, Mechanism of Action, Side effects, Contraindications, and Nursing considerations


Uses: 0:21
Action: 0:41
Side effects: 2:58
Contraindications: 3:24
Nursing considerations: 3:49

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Reference Images:
Icons: flaticon.com - Freepik

Itchy eyes image: allaboutvision.com - Itchy eyes: Causes and cures

Hypertension image: Eduard Robert @ Thinkstock/iStock

Choking image: Healthline.com - Can Allergies Cause Wheezing?

Vestibular system image: eyeandear.org.au - How does the balance system work?

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Intro: adMJ707
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Do you know about the DANGERS OF BENADRYL? I discuss what you need to know here!

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Diphenhydramine

Generic Name: diphenhydramine

Trade Name: Benadryl Indication allergy, anaphylaxis, sedation, motion sickness, antitussive

Action: antagonizes effects of histamine, CNS depression

Therapeutic Class: allergy, cold and cough remedy, antihistamine, antitussive

Pharmacologic Class: none

Nursing Considerations:
 may cause drowsiness, anorexia, dry mouth, nausea, chest tightness, thick secretions, hypotension, blurred vision, headache
 anticholinergic effects (dry mouth, blurred vision, constipation, sedation)
 assess purpose of medication prior to giving it
 assess allergies, sleep patterns, cough and lung sounds
 patient should avoid other over-the-counter cough and cold remedies