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First-gen Antihistamines Mnemonic for USMLE
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• 08/18/25
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Study this First-gen Antihistamines mnemonic and other mnemonics with Pixorize.
First generation antihistamines are a class of drugs that include Chlorpheniramine and Diphenhydramine. These drugs work by blocking histamine receptors, muscarinic receptors, and alpha-1 adrenergic receptors. Blocking H1 histamine receptors can reduce histamine-mediated vasodilation and vascular permeability, helping to treat allergy symptoms. Blocking muscarinic receptors can help to treat vestibular nausea, or motion sickness. However, due to their multiple mechanisms, first generation antihistamines also cause a variety of side effects. As antimuscarinic drugs, these drugs can cause anticholinergic symptoms like dry mouth, constipation, confusion, and hallucinations. Blockade of alpha-1 receptors can lead to orthostatic hypotension, characterized by lightheadedness and dizziness. Finally, blockade of histamine receptors can lead to sedation or drowsiness by blocking inhibiting centers in the brain.
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