*in the beginning of the video at 1.14 min, there is slip of tongue, it's adrenal gland NOT kidney from where corticosteroids are secreted.

Onset of action (missed in the video)
Hydrocortisone Onset of action: IV: 1 hour.
Methylprednisolone Onset of action: IV (succinate): Within 1 hour; Intra-articular (acetate): 1 week
Dexamethasone Onset of action: IV: Rapid.

Difference between various corticosteroids in ICU specifically Hydrocortisone, Methylprednisolone, Dexamethasone
#steroids_in_icu

This above video has tried to address and explain the following things:
Why we use difference steroids in icu,
difference between Hydrocortisone Methylprednisolone Dexamethasone,
when to use which corticosteroid in icu,
glucocorticoid and mineralocorticoid activity of corticosteroid,
duration of action of different corticosteroids,
orticosteroids explained in a simple way,


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Videoconsejo sanitario sobre Dexametasona, cuándo y cómo debemos administrar este principio activo. Videoconsejo impartido por el farmacéutico Eduardo Ramírez, elaborado por el Consejo General de Colegios Farmacéuticos y producido por Medicina TV.

Dexametasona es un glucocorticoide altamente potente y de larga duración, con una intensa actividad antiinflamatoria y con propiedades antialérgicas, antipiréticas e inmunosupresoras.

Se encuentra disponible en forma de colirio en solución o suspensión, pomada oftálmica, gotas óticas, implante intravítreo, comprimidos, solución inyectable, bucal y laringofaríngea y gel oftálmico.

La concentración más habitual de los formatos vía oftálmica es de 1 mg/ml en colirios y gel y 0,5 mg/g en pomada. Para los comprimidos, existen comercializadas dosis de 1, 4, 8 y hasta 20 mg. En el caso de las soluciones inyectables la dosis más habitual es la de 4 mg/ml.

A nivel oftálmico, dexametasona en colirio se administra habitualmente con 1 gota de 3-6 veces al día, y en pomada de 2-3 veces al día.
o Dexametasona oftálmica está indicada para el tratamiento de las inflamaciones de la conjuntiva bulbar y palpebral, córnea, y enfermedades inflamatorias del segmento anterior del ojo. También para el tratamiento de lesiones de la córnea por cuerpo extraño, químicas o térmicas.
o Además, tiene indicación para tratar determinados tipos de queratitis y queratoconjuntivitis, y en el caso de inflamación postoperatoria ocular.

En el caso de los comprimidos, las dosis habituales son de 0,5 a 10 mg al día, dependiendo de la enfermedad que esté siendo tratada, las características individuales y usando la menor dosis efectiva posible.

Para la administración parenteral, se suelen administrar dosis iniciales relativamente altas, siendo mayores en las formas agudas graves que en las enfermedades crónicas.

Entre sus indicaciones en tratamientos sistémicos, se encuentran el tratamiento de procesos endocrinológicos como en la enfermedad de Addison, o para el tratamiento de procesos alérgicos graves resistentes a los tratamientos convencionales, como en el asma.

También para el tratamiento sistémico de brotes en la enfermedad de Crohn o la colitis ulcerosa.

A nivel dermatológico, se usa como tratamiento inicial de enfermedades graves, como la dermatitis exfoliativa o la psoriasis severa.

También se utiliza en algunos cuadros hematológicos por vía intravenosa, y como coadyuvante para el tratamiento de patologías reumáticas en cuadros agudos y exacerbaciones, como artritis o artrosis.

Mediante inyección local, está indicada en crisis agudas de epicondilitis, artritis gotosa, o lesiones de naturaleza inflamatoria e hipertrófica, como la psoriasis.

Debido a que atraviesa la barrera hematoencefálica, también cuenta con indicación para el tratamiento del edema cerebral secundario a determinadas patologías.

Recientemente, se ha autorizado el uso en el tratamiento de la COVID-19 en asociado a oxigenoterapia.

Dexametasona está contraindicado en pacientes que tengan una infección sistémica a, menos que se emplee un tratamiento antiinfeccioso específico, en la úlcera de estómago o úlcera duodenal y en vacunación con vacunas vivas.

En el caso de embarazo y lactancia, la decisión de prescribirla debe evaluarse cuidadosamente por el profesional sanitario, valorando beneficios y riesgos.

En la población pediátrica en tratamiento prolongado con dexametasona, habrá que monitorizar la tasa de crecimiento regularmente, ya que los corticosteroides pueden afectar al crecimiento.

Los efectos adversos dependen en mayor grado de la duración del tratamiento que de la dosis empleada.

Los más habituales son, a corto plazo, el aumento de peso, trastornos psicológicos, intolerancia a la glucosa e insuficiencia suprarrenal transitoria. Si el tratamiento se mantiene durante meses o años, puede provocar obesidad central, fragilidad de la piel, atrofia muscular, osteoporosis, retraso del crecimiento e insuficiencia suprarrenal.

Las dosis se deben reducir gradualmente para finalizar el tratamiento, por riesgo de síndrome de retirada o recurrencia de la enfermedad subyacente.

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A cheap and widely available steroid can help save the lives of patients seriously ill with coronavirus, a trial has found.

The discovery about dexamethasone is a major breakthrough in the fight against the virus, UK experts say.

Read the full story here: https://www.independent.co.uk/....news/health/dexameth

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According to a new study, patients with breast, pancreatic and certain other types of cancer may survive longer if given an anti-nausea drug during surgery.

The findings of the study were presented at the ANESTHESIOLOGY 2021 annual meeting.

Three months after their cancer surgery, more than three times as many patients who did not receive dexamethasone died, compared to those who received the drug, researchers found.

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The Journal of Emergency Medicine released an article discussing the use of corticosteroids in severe asthma and COPD.

Original Article : https://www.jems.com/2017/05/0....1/appropriate-select

Dexamethasone or Methylprednisone, Is one better than the other?

*This video was made to supplement the original JEMS article https://www.jems.com/2017/05/0....1/appropriate-select , all scientific references are available in the article*

Les responsables de l'essai clinique britannique Recovery ont découvert qu'un médicament de la famille des stéroïdes, le dexamethasone, réduisait d'un tiers la mortalité chez les malades les plus gravement atteints.

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Inaprubahan na sa Japan ang paggamit ng dexamethasone, isang murang steroid drug, bilang treatment sa COVID-19. Ayon sa mga eksperto, ang dexamethasone ang kauna-unahang gamot na nakapagpababa ng mortality rate ng COVID-19 patients, base sa isang clinical trial.

Gagamitin ito ng Japan bilang second treatment para sa sakit, kasabay ng anti-viral drug na remdesivir.

Ang buong detalye, alamin sa video.

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Dexamethasone is the first drug to be shown to improve survival of Coronavirus.

The low-dose steroid treatment reduces death by one third in ventilated patients and by one fifth in other patients receiving oxygen only.

The results come from the UK’s Recovery Trial, led by Oxford University, which was established to find potential treatments for Covid 19.

#Dexamethasone #Coronavirus #LBC

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Scientists say a major breakthrough has been achieved in the fight against the coronavirus pandemic. Dexamethasone, a steroid has reduced mortality in patients with severe COVID-19. It is an inexpensive and a commonly available drug. The use of this drug has shown improvement in survival among COVID-19 patients in U.K.

Dexamethasone reduces deaths from COVID-19, say researchers in U.K. Read more here: https://www.thehindu.com/sci-t....ech/health/coronavir

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Learn all about the Dexamethasone Suppression Test in this super FUN and MEMORABLE video! Great for USMLE review!

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WHO "덱사메타손, 반가운 소식…중증환자에 사용해야"

An initial clinical trial out of the U.K. has shown that a cheap and affordable steroid can be lifesaving for patients who are critically ill with COVID-19.
The World Health Organization has welcomed the news,... but stressed the need for further tests and for it only to be administered under close medical supervision.
Lee Seung-jae has more.
Used since the 1960s to reduce inflammation caused by diseases such as arthritis,... dexamethasone,... is a corticosteroid that has been found to be lifesaving for patients who are critically ill with COVID-19.
Especially for patients on ventilators,... the treatment was shown to reduce mortality by about one-third,... and for patients requiring only oxygen,... mortality was cut by about one-fifth.
According to the latest preliminary findings shared with the WHO,... the benefit was only seen in patients who were seriously ill with COVID-19,... and was not observed in patients with milder cases.
While the latest finding is being seen as a breakthrough in the fight against COVID-19,... the WHO stressed that it's only based on preliminary data.
"It is one of the many breakthroughs we're going to need in order to effectively deal with COVID-19 and as such, we should celebrate that today but it's still just preliminary data. It's from one study. It's very significant, but we also have to see the real data, the full data."
The head of the WHO also stressed the need for caution,... adding that more treatments are needed for those with milder symptoms.
"These drugs should only be used under close medical supervision. We need more therapeutics that can be used to tackle the virus, including those with milder symptoms."
The drug has also been used in the treatment of some cancers,... and has been listed on the WHO's Model List of Essential Medicines since 1977.
It's also currently off-patent and affordable in most countries.
Lee Seung-jae, Arirang News.

#WHO #dexamethasone #COVID19

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A simple explanation of why you would do a dexamethasone suppression test and how to interpret the results.

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. Dexamethasone

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Errata: Th1 and Th2 are reversed in diagram and narrative.


Oxford RECOVERY Trial statement
https://www.recoverytrial.net/....files/recovery_dexam

Statnews article for dexamethasone results
https://www.statnews.com/2020/....06/16/major-study-fi


WHO Statement for Dexamethasone
https://www.who.int/news-room/....detail/16-06-2020-wh

Warning: abrupt withdrawal can cause acute adrenal insufficiency ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Corticosteroids are fast-acting medications used to reduce inflammation during IBD flare-ups.
In this short video, learn when corticosteroids like prednisone are prescribed for Crohn’s disease or ulcerative colitis, how they work, and what side effects patients should monitor.
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A mnemonic to help you remember what are the side effects of corticosteroids! This quick mnemonic is CORTICOSTEROIDS and is an easy way to remember the side effects of corticosteroids.

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Corticosteroid Side Effects, How to reduce risk?
What side effects can corticosteroids cause?
Fluid retention, causing swelling in your lower legs.
High blood pressure.
Problems with mood swings, memory, behavior, and other psychological effects, such as confusion or delirium.
Upset stomach.

What are the side effects of corticosteroid drugs?
Potential side effects of long-term treatment include:
increased appetite – potentially leading to weight gain.
acne.
thinned skin that bruises easily.
increased risk of infections.
mood changes, mood swings and depression.
diabetes.
high blood pressure.
osteoporosis (weak and brittle bones)

What are the most common side effects of corticosteroids?
What are the possible side effects of steroids?
Increased appetite.
Weight gain.
Changes in mood.
Muscle weakness.
Blurred vision.
Increased growth of body hair.
Easy bruising.
Lower resistance to infection

What does corticosteroid do to the body?
Corticosteroids can reduce inflammation in the body and relieve related symptoms, such as body pain, swelling, and stiffness. Corticosteroids reduce inflammation by suppressing the immune system. They are a standard treatment for autoimmune conditions, which often cause inflammation in the body.

What are the side effects of long-term treatment with corticosteroids?
Long-term corticosteroid use may be associated with more serious sequel, including osteoporosis, aseptic joint necrosis, adrenal insufficiency, gastrointestinal, hepatic, and ophthalmologic effects, hyperlipidemia, growth suppression, and possible congenital malformations.

How long do steroids stay in your system?
How long will it be detectable? If taken orally, steroids can show up in a urine test for up to 14 days. If injected, steroids can show up for up to 1 month.

How long is long term steroid use?
Treatment extending longer than three months is considered long term and results in the majority of severe side effects. When steroids are used for short durations of a few days or weeks, they are relatively safe.

What drugs should not be taken with steroids?
You should tell any doctor or dentist treating you that you are taking steroids. Some key drugs that interact with steroids include anticoagulants (such as warfarin), drugs for blood pressure, antiepileptics, antidiabetic drugs, antifungal drugs, bronchodilators (such as salbutamol) and diuretics.

Are steroids the same as corticosteroids?
Corticosteroids are a form of steroids used to treat swelling and inflammation from allergies, as well as allergic asthma. They're often referred to as steroids, but they're not the same types of products abused by some athletes. Corticosteroids may be used for a range of allergies.
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What is moon face?
Moon facies occurs when extra fat builds up on the sides of the face. It is often related to obesity but can be from Cushing's syndrome. That's why people sometimes refer to it as a Cushingoid appearance

What is the best known corticosteroid?
Among the systemic (oral and injectable) corticosteroids, fludrocortisone (Florinef) has the most significant mineralocorticoid (salt retaining) actions and is best used for this effect despite it's strong anti-inflammatory action.

Does your body go back to normal after prednisone?
A gradual reduction in prednisone dosage gives your adrenal glands time to resume their usual function. The amount of time it takes to taper off prednisone depends on the disease being treated, the dose and duration of use, and other medical considerations. A full recovery can take a week to several months.

#prednisone #corticosteroids #fludrocortisone #medication #pharmacy #pharmacist #pharm #pharmacology #pharmaceutical #medical #medicaldoctor #doctor #usmle

Can corticosteroids damage skin?
Topical corticosteroids, though very useful for treatment of dermatological disorders can produce various side effects. Some of these side effects may seriously damage the skin. Hence, topical corticosteroids should be used with utmost caution.
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Does Dexamethasone Cause Muscle Weakness? In this informative video, we will address an important topic related to pain management: the potential side effects of dexamethasone, specifically focusing on muscle weakness. Dexamethasone is a commonly prescribed corticosteroid known for its effectiveness in reducing inflammation. However, like many medications, it may come with certain side effects that patients should be aware of.

We will discuss how muscle weakness can occur as a result of dexamethasone use and explain the condition known as corticosteroid-induced myopathy. Understanding the symptoms associated with this condition is essential for anyone taking dexamethasone, as it can significantly affect daily activities and overall health.

Additionally, we will explore strategies for managing potential muscle weakness while on dexamethasone, including the importance of monitoring symptoms, dosage adjustments, and engaging in supportive exercises. It's vital to maintain an open line of communication with your healthcare provider to ensure the best possible outcomes while using this medication.

Join us for this detailed discussion on dexamethasone and its effects on muscle strength. Don't forget to subscribe to our channel for more helpful information on pain medicine and management.

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Nagpalabas ng babala ang Food and Drug Administration (FDA) sa panganib na maaaring idulot sa kalusugan ng tao ng dexamethasone nang walang paggabay ng isang doktor.

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In this week’s #AskDrDurie myeloma expert Dr. Brian G.M. Durie discusses dexamethasone and how it is used to enhance myeloma therapies.

The BOTTOM LINE: Patients should discuss the dosing and scheduling of dexamethasone with their doctor.
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