Pioglitazone Anti- Diabetic medicine

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Pioglitazone is an oral medication used to manage type 2 diabetes mellitus. It belongs to the thiazolidinedione class of drugs and works by improving insulin sensitivity in the body, helping to control blood sugar levels. Below are its uses and typical dosing:

Uses of Pioglitazone
1. Type 2 Diabetes Management:
- Used as an adjunct to diet and exercise to improve glycemic control.
- Can be used alone or in combination with other antidiabetic medications, such as metformin, sulfonylureas, or insulin.

2. Polycystic Ovary Syndrome (PCOS)(off-label):
- Sometimes prescribed to improve insulin resistance in women with PCOS.

Dosage of Pioglitazone:
Standard Starting Dose: 15–30 mg once daily.
Maximum Dose: 45 mg once daily.
Administration: Taken orally, with or without food.
Adjustments:
- Dose adjustments may be made based on blood glucose levels and tolerability.
- If used in combination with insulin or other antidiabetic drugs, the dose of these medications may need to be reduced to avoid hypoglycemia.

Important Considerations
1. Monitoring:
- Regular monitoring of blood glucose levels, HbA1c, and liver function tests is recommended.
2. Contraindications:
- Not recommended for patients with heart failure (NYHA Class III or IV) or active liver disease.
3. Side Effects:
- Common: Weight gain, fluid retention, and edema.
Rare but serious: Bladder cancer (long-term use), fractures (especially in women), and liver toxicity.
4. Pregnancy and Lactation:
Not recommended during pregnancy or breastfeeding.

Always consult a healthcare provider for personalized dosing and to ensure safe use of pioglitazone.



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Actos | Medicine Information

Actos is a brand name for the drug pioglitazone, which is used to treat type 2 diabetes. Pioglitazone is a member of the thiazolidinedione class of drugs and works by improving insulin sensitivity in the body, which helps to lower blood sugar levels.

Actos is usually taken orally once daily, with or without food. The dosage may vary depending on the patient's medical history, response to treatment, and other factors. It is important to take Actos exactly as prescribed by a healthcare provider and to monitor blood sugar levels regularly while taking the medication.

Like all medications, Actos may cause side effects, some of which may be serious. Common side effects of Actos include weight gain, edema (swelling), and headache. More serious side effects may include liver problems, heart failure, and an increased risk of bladder cancer, although the risk of bladder cancer is considered to be relatively low.

It is important for patients to discuss any concerns they have about Actos with their healthcare provider and to report any unusual symptoms or side effects while taking the medication.

Pioglitazone tablet | Pioglitazone hydrochloride tablet | Pioz 15 mg tablet
Pioglitazone is thiazolidinedione class drug which is also known as PPAR activator. Pioglitazone is also names as Pioglitazone hydrochloride tablets. Pioglitazone is available in different strength like
1. Pioglitazone 7.5 mg tablet | Pioz 7.5 | Pioglit 7.5
2. Pioglitazone 15 mg tablet | Pioz 15 mg tablet
3. Pioglitazone 30 mg tablet
4. Pioglitazone 45 mg tablet
Popular brand name are
1. Pioz 15 mg tablet
2. Pioglit tablet
3. Pioglor tablet
4. Pionorm tablet
5. Piomed tablet and many more
Pioglitazone hydrochloride ip tablet is used to treat or control type 2 diabetes mellitus with the combination of metformin and glimepride.

Pioglitazone side effects are
1. Edema
2. Blurred vision
3. Myalgia
4. Mild anemea
5. Headache
6. Weight gain
And some severe side effects are
1. Liver dysfunction
2. Heart failure
3. Increase the risk of fracture in elderly women
4. Failure of oral contraceptive and many more
We also learn about pioglitazone tablet
Pioglitazone Group
Pioglitazone Brand name
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Pioglitazone dosage and which are the patient who cannot take pioglitazone.

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A brief talk on pioglitazone side effects

Diabetes Medications - DPP 4 inhibitors - Alogliptin and Pioglitazone (Incresync)

Actos, Pioglitazone, thiazolidinedione-type, glitazones Abilify Methocarbamol
Acetaminophen Methotrexate
Adderall Metoprolol
Alprazolam Metronidazole
Amantadine Miralax
Ambien Mirtazapine
Amitriptyline Mounjaro
Amlodipine Mucinex
Amoxicillin Naloxone
Ativan Naltrexone
Atorvastatin Naproxen
Avastin Omeprazole
Azithromycin Opdivo
Baclofen Ondansetron
Belsomra Otezla
Benadryl Oxycodone
Benzonatate Ozempic
Biktarvy Pantoprazole
Botox Penicillin
Brilinta Percocet
Bunavail Phentermine
Buprenorphine Plan B
Bupropion Praluent
Buspirone Prednisone
Cephalexin Prolia
Cetirizine Promethazine
Ciprofloxacin Propranolol
Citalopram Prozac
Clindamycin Qulipta
Clonazepam Repatha
Clonidine Restasis
Cosentyx Rexulti
Cyclobenzaprine Rytary
Cymbalta Seroquel
Dexamethasone Sertraline
Diazepam Sildenafil
Diclofenac Sinemet
Doxycycline Skyrizi
Duloxetine Spironolactone
Dupixent Stelara
Eliquis Sublocade
Enbrel Suboxone
Entyvio Subutex
Epclusa Taltz
Ezetimibe Tamsulosin
Famotidine Tizanidine
Farxiga Toradol
Fluoxetine Toujeo
Furosemide Tramadol
Gabapentin Trazodone
Humira Trelegy
Hydrochlorothiazide Trintellix
Hydrocodone Tylenol
Hydroxyzine Ubrelvy
Ibuprofen Valium
Januvia Vascepa
Jardiance Venlafaxine
Keytruda Verzenio
Klonopin Viagra
Levothyroxine Vivitrol
Lexapro Vraylar
Lisinopril Vyvanse
Loratadine Wellbutrin
Lorazepam Xanax
Losartan Xolair
Lyrica Zetia
Meloxicam Zoloft
Metformin Zyrtec
Methadone

Thiazolidinediones (TZDs), also known as glitazones, are a class of oral medications used primarily to manage type 2 diabetes mellitus. These drugs work by improving the body's response to insulin and helping to lower blood sugar levels. They do so by targeting insulin resistance, a key factor in type 2 diabetes where the body's cells don't respond effectively to the insulin produced, leading to elevated blood sugar levels.

There are three main thiazolidinediones that have been approved for medical use:

1. Rosiglitazone: This medication enhances insulin sensitivity in muscle and adipose (fat) tissues. It activates peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that regulates glucose and fat metabolism. Rosiglitazone increases the uptake of glucose by muscle cells and reduces the production of glucose by the liver.

2. Pioglitazone: Like rosiglitazone, pioglitazone also activates PPARγ to improve insulin sensitivity. It helps regulate glucose levels by increasing the uptake of glucose into muscle cells and decreasing glucose output from the liver.

3. Troglitazone: This was the first thiazolidinedione approved for use, but it was later withdrawn from the market due to concerns about severe liver toxicity.

Thiazolidinediones are often used as a second-line treatment for type 2 diabetes when other medications like metformin or sulfonylureas aren't sufficient to control blood sugar levels. They can be used as monotherapy or in combination with other diabetes medications. However, they are not recommended for use in people with heart failure, severe liver disease, or a history of bladder cancer.

Benefits of thiazolidinediones include:

- Improvement in Insulin Sensitivity: These drugs target insulin resistance, which is a central problem in type 2 diabetes.

- Long-term Glucose Control: They have been shown to provide sustained blood sugar control over an extended period.

- Potential Cardiovascular Benefits: Some studies have suggested cardiovascular benefits, including improved lipid profiles and reduced risk of heart attack or stroke, although the safety and long-term effects are still debated.

However, thiazolidinediones are associated with certain risks and side effects:

- Weight Gain: Many individuals experience weight gain when taking these medications, which can exacerbate insulin resistance in the long run.

- Fluid Retention and Edema: Some people may develop fluid retention, leading to swelling (edema) in the legs and other body parts.

- Heart Failure Risk: Thiazolidinediones have been associated with an increased risk of heart failure, especially in those with pre-existing heart conditions.

- Bone Fracture Risk: Long-term use may increase the risk of bone fractures, possibly due to changes in bone density.

- Liver Effects: Monitoring liver function is crucial due to the potential for liver damage.

It's important for individuals considering thiazolidinediones to consult their healthcare provider, who can assess the potential benefits and risks based on their specific medical history and conditions. The use of these medications should be carefully considered, and close monitoring is necessary to ensure the best possible outcomes for diabetes management.

This particular compound which is mentioned here is a salt which somebody would have read over it. It is used for type 2 diabetes people who have non insulin dependent diabetes mellitus. This medicine is supposed to sensitize your body to insulin. For it to cause cancer or not is absolutely dependent on your doctor, on how he is tapering the doses, how well your blood sugar is monitored, and how good are you with your lifestyle changes so that you don’t need a drug for too long. If we start depending on drugs for too long they will have some or the other chemical deposits in the body. Diabetes is supposed to be a lifestyle disorder. If you want to alter a lifestyle disorder you will have to alter your lifestyle. Come to the naturopathic way of it. You will be free of it. You will not need any medication. Over medication can be a cause of cancer. Not the medicine itself.

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Actos (Pioglitazone) is an anti-diabetic medicine used to treat type 2 (non-insulin dependent) diabetes mellitus. Actos tablets helps control the level of sugar in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.

Actos for Type II Diabetes.

This video was made by Tram Nguyen, 2021 Pharmacist Candidate. She will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters.

Pioglitazone can be an essential ally in the treatment of type 2 diabetes. In this video, we explain how this medication helps control blood sugar levels by improving the sensitivity of cells to insulin, allowing your body to use insulin more efficiently. In addition, we provide key tips on the importance of following medical instructions for dosing and being aware of possible side effects and contraindications.

#Type2Diabetes #SugarControl #Health #Pioglitazone #DiabetesCare

Pioglitazone is a thiazolidinedione that acts by activation of Peroxisome Proliferator Activated Receptor (PPAR) gamma. This drug increases the sensitivity of Insulin but it doesn't increase release of insulin.

This video explains some common side effects of pioglitazone.

@ProfessorTushar

Your Medication Pioglitazone

Pioglitazone is also known as the brand name: Actos

Pioglitazone comes as a tablet dosage form.

Pioglitazone is most commonly used for type 2 diabetes. Pioglitazone is usually taken once daily by mouth with or without food. It is important to follow a healthy diet and to exercise.

Standard dosing of pioglitazone ranges from 15 mg to 45 mg daily

Some common side effects with pioglitazone include swelling in hands or feet, lightheadedness or shaking, runny nose, and sore throat.
Some less common side effects with pioglitazone include headache, heart failure, and muscle and bone weakness.

Do not take pioglitazone if:
• You have heart failure
• You are allergic to pioglitazone

While taking pioglitazone, remember it is important to tell your doctor or pharmacist if you:
• Have signs of an allergic reaction, such as rash, itching, swelling, or tightness of the chest
• Experience changes in your vision or blurred vision.
• Have blood in your urine, pain when you urinate, increase in the amount of urine you make daily, or pain in the lower back
• Start taking new medications, vitamins, or supplements.

Pioglitazone may weaken your bones; so discuss with doctor or pharmacist a way to keep them strong.

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Chapters

0:09 Introduction
0:25 Uses
1:05 Doses
1:48 side effects
2:39 Warnings




Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes.[2] It may be used with metformin, a sulfonylurea, or insulin.[2][3] Use is recommended together with exercise and diet.[3] It is not recommended in type 1 diabetes.[3] It is taken by mouth.[3]

Common side effects include headaches, muscle pains, inflammation of the throat, and swelling.[3] Serious side effects may include bladder cancer, low blood sugar, heart failure, and osteoporosis.[3][2] Use is not recommended in pregnancy or breastfeeding.[2] It is in the thiazolidinedione (TZD) class and works by improving sensitivity of tissues to insulin.[2]

Pioglitazone was patented in 1985, and came into medical use in 1999.[4] It is available as a generic medication.[2] In 2019, it was the 179th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[5][6] It was withdrawn in France and Germany in 2011.[7][8][9] Pioglitazone is used to lower blood glucose levels in type 2 diabetes either alone or in combination with a sulfonylurea, metformin, or insulin.[1] The effects of Plioglitazone have been compared in a Cochrane systematic review to that of other blood sugar lowering-medicine, including metformin, acarbose, and repaglinide, as well as with appropriate diet and exercise, not showing any benefit in reducing the chance of developing type 2 diabetes in people at risk.[10] It did, however, show reduction of risk of developing type 2 diabetes when compared to a placebo or to no treatment.[10] These results should be interpreted considering that most of the data of the studies included in this review were of low or very-low certainty.

While pioglitazone does decrease blood sugar levels, the main study that looked at the medication found no difference in the main cardiovascular outcomes that were looked at.[11] The secondary outcome of death from all causes, myocardial infarction, and stroke were lower.[11]

Pioglitazone has been found to reduce all-cause mortality in type 2 diabetic patients compared to other therapies, with a 60% reduction in mortality in those exposed to pioglitazone, compared to those never exposed.[12] Another study found an all-cause mortality hazard ratio of 0.33 for pioglitazone after adjusting for 40 covariates, compared to insulin.[13] Due to insufficient data on all-cause mortality, cardiovascular mortality, myocardial infarction and stroke, this was not possible to compare in a more recent review.[10]