ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE generic medicine: USES, DOSAGE & SIDE EFFECTS.

Uses:
What Is Acetaminophen Pheniramine Phenylephrine Used For and How Does it Work?.

Dosage:
What Are the Dosages of Acetaminophen Pheniramine Phenylephrine?.

Side Effects:
What Are Side Effects Associated with Using Acetaminophen Pheniramine Phenylephrine?.

Drugs Interactions:
What Other Drugs Interact with Acetaminophen Pheniramine Phenylephrine?.

Warning and Precautions:
What Are Warnings and Precautions for Acetaminophen Pheniramine Phenylephrine?.

WHAT IS ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE AND HOW DOES IT WORK?

Acetaminophen pheniramine phenylephrine is an over-the-counter (OTC) product used to treat allergy symptoms and common cold symptoms.

Acetaminophen pheniramine phenylephrine is available under the following different brand names: Theraflu Cold & Sore Throat and Theraflu Flu & Sore Throat.


WHAT ARE THE DOSAGES OF ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

Dosages of Acetaminophen Pheniramine Phenylephrine:

Dosage Forms and Strengths:

Powder:

325mg per packet.
20mg per packet.
10mg per packet.

Dosage Considerations – Should be Given as Follows:

Allergy Symptoms and Common Cold:

Adults and children 12 years of age and older: Dissolve contents of 1 packet in 8 oz of hot water; consume entire 8 oz within 10-15 minutes; not to exceed acetaminophen 1 g/dose or 4 g/day.

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

Side effects of acetaminophen pheniramine phenylephrine include:

Low blood pressure (hypotension).
Palpitations.
Reflex high blood pressure (hypertension).
Severe peripheral and visceral vasoconstriction.
Fast heart rate.
Confusion.
Dizziness.
Depression.
Distress.
Euphoria.
Fatigue.
Headache.
Insomnia.
Irritability.
Restlessness.
Sedation.
Tremors.
Dermatologic rash.
Loss of appetite.
Severe low white blood cell count (agranulocytosis).
Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia).
Hemolytic anemia.
Low blood platelets (thrombocytopenia).
Increased bilirubin and alkaline phosphatase.
Thickening of bronchial secretions.
Wheezing.

WHAT OTHER DRUGS INTERACT WITH ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Serious interactions of acetaminophen pheniramine phenylephrine include:
pexidartinib.
pitolisant.
pretomanid.

Moderate interactions of acetaminophen pheniramine phenylephrine include:
apalutamide.
avapritinib.
axitinib.
brexanolone.
busulfan.
cenobamate.
daclizumab.
dapsone topical.
eltrombopag.
exenatide injectable solution.
exenatide injectable suspension.
flibanserin.
imatinib.
isoniazid.
ivacaftor.
lasmiditan.
lemborexant.
levonorgestrel oral, ethinylestradiol/ferrous bisglycinate.
midazolam intranasal.
lixisenatide.
lomitapide.
midazolam intranasal.
mipomersen.
stiripentol.
tazemetostat.


WHAT ARE WARNINGS AND PRECAUTIONS FOR ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

Warnings:

This medication contains acetaminophen pheniramine phenylephrine. Do not take Theraflu Cold & Sore Throat or Theraflu Flu & Sore Throat if you are allergic to acetaminophen pheniramine phenylephrine or any ingredients contained in this drug.

Contraindications:

Hypersensitivity.
Asthma.
Children under 2 years old.
Narrow-angle glaucoma.
Symptomatic prostate hypertrophy.
Bladder-neck obstruction.
Stenosing peptic ulcer.
Use within 14 days of monoamine oxidase inhibitor (MAOI) therapy.
G-6-PD deficiency.
Severe hepatic impairment.

Cautions:

Pheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates.
Phenylephrine: Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe atherosclerosis.
Acetaminophen: Hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose.
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash.

Pregnancy and Lactation:

Use acetaminophen pheniramine phenylephrine with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
Acetaminophen pheniramine phenylephrine is excreted in breast milk. Use caution while breastfeeding.

Phenylephrine is a sympathomimetic agent used primarily as a nasal decongestant and to treat hypotension. Here are some key points about its pharmacology:

Mechanism of Action
Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, causing vasoconstriction of blood vessels. This reduces blood flow and helps relieve nasal congestion2. It also increases total peripheral resistance and raises blood pressure.

Pharmacokinetics
Absorption: Phenylephrine is well absorbed orally, intranasally, and through other routes.

Onset of Action: The effects typically begin within 15 to 30 minutes.

Duration of Action: The effects last for about 2 to 4 hours.

Elimination Half-Life: The half-life is approximately 2 to 3 hours.

Excretion: It is excreted primarily in the urine, both unchanged and as metabolites.

Indications
Nasal Congestion: Used as a nasal spray or drops to relieve nasal congestion due to colds, allergies, or sinusitis.

Hypotension: Used intravenously to treat low blood pressure, especially during surgery.

Mydriasis: Used in ophthalmology to dilate the pupil.

Hemorrhoids: Applied topically or as a suppository to relieve hemorrhoids.

Dosage
Nasal Congestion: Apply 2 to 3 drops or sprays of 0.25% to 1% solution in each nostril every 4 to 6 hours, not more than 3 times in 24 hours.

Hypotension: Intravenous administration starts with 0.1 to 0.5 mg every 15 minutes, adjusted based on patient response.

Mydriasis: Typically, 1 to 2 drops of 2.5% solution in each eye.

Side Effects
Common: Nausea, vomiting, headache, anxiety, and dry mouth.

Serious: Hypertension, bradycardia, arrhythmias, and tissue necrosis at the injection site.

Contraindications
Hypersensitivity to phenylephrine or any of its components.

Severe Hypertension: Avoid use in patients with severe high blood pressure.

Coronary Artery Disease: Avoid use in patients with coronary artery disease.

Glaucoma: Avoid use in patients with glaucoma.

Pregnancy and Breastfeeding: Use with caution and only if the potential benefits outweigh the risks.

Special Precautions
Cardiovascular Diseases: Use with caution in patients with heart conditions.

Diabetes: Use with caution in patients with diabetes.

MAO Inhibitors: Avoid concurrent use with MAO inhibitors

#Phenylephrine

🚨 FDA Questions Phenylephrine’s Effectiveness! 🤧💊

Phenylephrine, a common OTC decongestant, is under scrutiny for not working effectively when taken orally due to poor absorption and first-pass metabolism in the liver. The FDA advisory committee has reviewed studies suggesting that it provides little to no relief, leading to discussions about its removal from the market.

🔹 Why is phenylephrine ineffective?
🔹 What are better alternatives for nasal congestion?
🔹 Will the FDA ban it completely?

Find out everything you need to know in this deep dive! ⬇️

#Phenylephrine #FDABan #NasalCongestion #ColdMedicine #Decongestant #HealthNews #MedicalFacts #Pharmacology #DoctorExplains

Injection phenylephrine | indications, contra indication | drug dilution and dose calculations @anaesthesiawithbabar2576

Injection phenylephrine | indications, contra indication | drug dilution and dose calculations @anaesthesiawithbabar2576
#phenylephrine
#vasoconstriction
#alphaagonist
Drug use for #spinal #shock
#septic shock #neurogenic shock

In this video, we delve into the details of phenylephrine, a potent vasopressor used to treat hypotension and vasodilatory shock. We explore its mechanism of action, dosages, side effects, contraindications, nursing considerations, drug interactions, and pharmacokinetics. Viewers are encouraged to grasp the essential information for safe and effective administration of phenylephrine.

Please read and agree to the disclaimer before watching this video.
. Phenylephrine is an alpha 1-agonist, usually given intravenously in 50-100 mcg boluses but can also be run as an infusion of 20-100 mcg/min.
It takes 45-60 seconds to take effect and lasts 5-10 minutes.
In this video, Dr. Luis Verduzco discusses the effects of both phenylephrine and ephedrine on the cardiovascular system.
The use of phenylephrine causes a few side effects, including potent reflex-bradycardia and decreased cardiac output.
It is contraindicated in patients with cardiogenic shock.
Ephedrine is an indirect agonist and is used more often in anesthesia than in the ICU.
It is usually given intravenously in 5-10 mg boluses.
It takes 3 minutes to take effect and lasts between 10-30 minutes.
Ephedrine causes the release of norepinephrine tissue stores.
It is contraindicated in patients with pheochromocytoma and chronic users of amphetamines and TCA/MAO inhibitors.

The following topics have discussed in the video:
* Effective dose of phenylephrine
* Duration of action of phenylephrine
* Side effects of phenylephrine
* Contraindications for phenylephrine
* Effective dose of ephedrine
* Duration of action of ephedrine
* Side effects of ephedrine
* Contraindications for ephedrine ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Hello my friends

Here, I described the uses and side effects of Phenylephrine..

Use the PharmacoPhoto video 'flash-card' series to reinforce your knowledge of drug classes and specific medications.

After an FDA report that said many cold and sinus medicines are not effective, NBC Chicago’s Lauren Petty takes a look at treatments that do work to help with congestion.

When it is that time of year and you have a stuffy nose that won’t clear up, over the counter medications at your pharmacy can help. Today I’m going to talk about phenylephrine, also known as Sudafed PE.

Phenylephrine, sold under the name brands Sudafed PE and Sudogest PE, is a nasal decongestant used to treat nasal congestion caused by a cold, infection, or allergies. It is included in many combination OTC medications for cold, flu, and congestion.

Adults should take one tablet (10 mg) of phenylephrine every 4 hours as needed. Do not take more than six tablets (60mg) in one day and do not take for more than 7 days. Children younger than 12 take a smaller dose based on age.

Talk to your doctor or pharmacist before giving phenylephrine to a child. Like all OTC medications, follow the instructions on the package unless instructed otherwise by your doctor.

Common side effects of phenylephrine include anxiety, dizziness, restlessness, difficulty sleeping, or an upset stomach. Taking this medicine with food if you have an upset stomach. Tell your doctor if you experience signs of high blood pressure, including bad headache, dizziness or passing out. Other symptoms to tell your doctor about include chest pain, fast heartbeat, nervousness, or shakiness.

If you have high blood pressure, thyroid problems, take medicine for mood (including depression and anxiety), or are pregnant or breastfeeding, be sure to talk to your doctor or pharmacist before taking phenylephrine. Do not take this medication if you are allergic to phenylephrine or any related drug, including pseudoephedrine. If you are 65 years or older, check with your doctor or pharmacist before use, as you could be more predisposed to the adverse effects of phenylephrine.

Phenylephrine, or Sudafed PE, is a nasal decongestant you can take it for a stuffy nose. There are other medications available to help when you have a cold, allergies, or a sinus infection. Your pharmacist will be able to help you choose the best over the counter option for you!

To end our Seasonal Allergy series, we're diving into pseudoephedrine products. Are they the best option for allergy season? Watch now to find out!

PHENYLEPHRINE, phenylephrine hydrochloride, phenylephrine hcl.


Phenylephrine hydrochloride (hcl) tablets - Uses, Side Effects, and More.
COMMON BRANDS: SUDAFED PE, SUDOGEST PE.
GENERIC NAME: PHENYLEPHRINE HCL.




What is phenylephrine hydrochloride (hcl)?




Phenylephrine is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis). This medication works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe. Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely. These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).




How to use Phenylephrine hcl 10 Mg Tablet.




If you are using the over-the-counter product, read and follow all directions on the product package before taking this medication.


Take this medication by mouth with or without food or as directed by your doctor. Taking it with food may decrease stomach upset.


If you are using the liquid, carefully measure your prescribed dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose.


If you are using chewable tablets, chew each tablet thoroughly before swallowing.


If you are using a product made to dissolve in the mouth (tablets or strips), dry your hands before handling the medication. Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or with water.


The dosage is based on your age. Do not increase your dose or take this medication more often than directed without your doctor's approval. Improper use (abuse) of this medication may result in serious harm (such as hallucinations, seizure, death).


If your symptoms worsen or do not improve after 7 days, if you develop fever/chills, or if you think you may have a serious medical problem, get medical help right away.




Side Effects.




Mild upset stomach, trouble sleeping, dizziness, lightheadedness, headache, nervousness, shaking, or fast heartbeat may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.


This product may reduce blood flow to your hands or feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.


If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.


Tell your doctor right away if you have any serious side effects, including: fast/irregular heartbeat, severe/uncontrolled shaking, difficulty urinating, seizures, mental/mood changes (such as anxiety, panic, confusion, unusual thoughts/behavior).


A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

A Food and Drug Administration Committee has confirmed that many over-the-counter cold medications don't actually work.

Phenylephrine (Neo-Synephrine) as a third line vasopressor, after Levophed and Vasopressin.

Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery.