Secukinumab (Cosentyx) is a human monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in autoimmune and inflammatory diseases. It is used for plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.

Pharmacology
Mechanism of Action: Secukinumab binds to IL-17A, preventing its interaction with IL-17 receptors. This reduces inflammation by inhibiting the release of proinflammatory cytokines.

Absorption: Administered subcutaneously, with peak levels reached in 2 to 6 days.

Metabolism: Cleared via proteolytic degradation.

Elimination: Slow clearance, with a half-life of ~22 days.

Clinical Uses
Plaque Psoriasis: Used for moderate-to-severe cases in adults.

Psoriatic Arthritis: Can be used alone or with non-biologic DMARDs.

Ankylosing Spondylitis: Helps reduce spinal inflammation and stiffness.

Hidradenitis Suppurativa: Approved for moderate-to-severe cases.

Adverse Effects
Infections (upper respiratory tract infections, fungal infections).

Hypersensitivity reactions (including anaphylaxis).

Exacerbation of Crohn’s disease (use with caution in patients with inflammatory bowel disease).

Avoid live vaccines during treatment.

#Secukinumab

Medication dosing details, proper storage techniques, administration procedures, side effects and more.

How does Taltz compare to Cosentyx for psoriatic arthritis Taltz and Cosentyx are similar in the way they work their side effects and their potential for interactions but Taltz does appear to provide patients with psoriatic arthritis PA with more qualityadjusted lifeyears QALYs compared with Cosentyx at a marginally lower cost Cosentyx may have a quicker onset of effectBoth Taltz and Cosentyx may be used to treat adults with psoriatic arthritis but Cosentyx is also approved for children with psoriatic arthritis over the age of years They both belong to the same class of medicines called interleukin inhibitors and work in the same way that is to selectively bind to interleukin A ILA to reduce inflammation Interleukin inhibitors are considered a breakthrough in psoriasis and psoriatic arthritis treatment because research has discovered that immune cell TH was a major cause of psoriasis and that interleukinA was the most abundant cytokine produced by TH cellsSide effects of Cosentyx and Taltz that are similar include infections such as those affecting the lungs nose or skin or a stuffy or runny nose Cosentyx is more likely to cause nasopharyngitis diarrhea oral herpes and urticaria and Taltz is more likely to cause nausea and has a higher incidence of injection site reactionsInteractions with medicines such as immunosuppressants warfarin and live vaccines are similar with Cosentyx and TaltzBoth are injections that need to be stored in the refrigerator at C to C F to F before useBoth start working within a few weeks but it may take up to months for the full effects of Cosentyx to be seen and up to months for the full effects of Taltz to developBoth Taltz and Cosentyx are associated with an increased risk of developing inflammatory bowel disease Report any symptoms such as diarrhea abdominal pain fever blood in the stool or weight loss to your doctorDifferences in effectivenessVery few studies have directly compared Cosentyx with Taltz with regards to psoriatic arthritis Taltz provided more qualityadjusted lifeyears QALYs compared with Cosentyx to patients with psoriatic arthritis PsA and concomitant moderate to severe plaque psoriasis at a marginally lower cost in one study published in PharmacoEconomicsAnother study that investigated patients with psoriasis reported that Cosentyx and Taltz were both highly effective in the short and longterm treatment of psoriasis but that Cosentyx had a more rapid onset and Taltz longer effectivenessOther differencesOther differences between Cosentyx and Taltz includeCosentyx is a brand trade name for secukinumab and Taltz is a brand trade name for ixekizumab Both are interleukin inhibitorsCosentyx is available as a Sensoready pen and prefilled syringe and an IV formulation that can be administered over minutes by a healthcare provider Taltz is available as the Taltz Autoinjector and the Taltz prefilled syringe People can be taught how to selfadminister the prefilled pens syringes and autoinjectorsCosentyx for self administration requires two injections per dose to be given because each injection is only mg and mg is the usual dose Cosentyx given by an IV infusion in your healthcare providers office is given into a vein over approximately minutesApart from the very first dose of Taltz which requires two mg injections to make mg every other dose of Taltz is just one injection of mgThe recommended dose of Cosentyx is mg by subcutaneous injection at Weeks and followed by mg every weeksThe recommended dose of Taltz is mg two mg injections at Week followed by mg at Weeks and then mg every weeksCosentyx should be thrown away if stored unrefrigerated for a single period of more than days at room temperature not above C Taltz can remain out of the refrigerator for up to five days at room temperature not above CNatural rubber latex is contained in the removable cap of the Cosentyx Sensoready pen and the Cosentyx prefilled syringe This may cause an allergic reaction in latexsensitive individuals if they handle the cap Taltz injections do not contain latexRelated questions What does psoriasis look like How do you get psoriasis and is it contagious How does Tremfya work to treat plaque and psoriatic arthritis

The newest injectable treatment for moderate to severe psoriasis, Cosentyx, works through a novel pathway and appears more effective than its competitors. It quiets the inflammation necessary for skin and joint manifestations of psoriasis. After an initial intensive regimen, a single, monthly, self-administered injection appears sufficient. However at a cost of about $4400 per dose, Cosentyx ranks as the most expensive biologic for psoriasis. Alternative drugs in the same family appear to increase suicide risk. Whether the same will plague Cosentyx remains unknown.

Secukinumab 25 Mg/Ml Intravenous Solution is a medication that is used to treat certain types of arthritis, including arthritis of the spine, psoriatic arthritis, and axial spondyloarthritis. It belongs to a class of drugs known as monoclonal antibodies. This medication works by blocking a certain natural protein in your body, called interleukin-17A, which may cause inflammation and swelling. It is important to take this medication as prescribed by your healthcare provider. The recommended daily dosage and the best time to take this medication will be determined by your doctor based on your specific condition.
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Latest about Cosentyx - the magic drug | DrAinFay


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Hi. With this video, we will discuss the use of Secukinumab in dermatology and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.

Introduction - 00:00
Pharmacokinetics - 06:18
Mechanism of Action - 10:14
Use in Psoriasis - 18:07
Other Uses - 22:03
Storage - 23:33
Investigations - 24:52
Administration - 27:03
Contra-indications - 32:36
Infections and Secukinumab - 36:02
Contra-indications - Others - 38:21
TB and Secukinumab - 40:21
Vaccination - 41:42
Drug Interactions - 42:37
Use in Pregnancy - 43:30
Other IL-17 Inhibitor - Ixekizumab - 44:50
Other IL-17 Inhibitor - Brodalumab - 46:34
End - 50:35

This is my 10th month on Cosentyx and I feel amazing.  I do have a slight cough that may be a side effect of using the medication but if it makes me feel good as far as no skin lesions and no pain, then I’ll deal with it for now.

General information regarding Secukinumab (Cosentyx). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

Victoria Ruffing, RN, BC, is the Director of Nursing and Patient Education at the Johns Hopkins Arthritis Center. She walks through how to safely inject this medication.

Treatment for Psoriasis

Dr. Robert Chao discusses abstract 0427 presented at ACR22 convergence.

Abstract 0427: Recapture Rates with Ixekizumab After Withdrawal of Therapy in Patients with Axial Spondyloarthritis: Results at Week 104 from a Randomized Placebo-controlled Withdrawal Study

Cosentyx is a revolutionary drug that has garnered attention in the medical community for its impressive effectiveness. It belongs to a class of medications known as interleukin-17A (IL-17A) inhibitors. This means that it specifically targets and blocks the action of IL-17A, a protein that plays a crucial role in promoting inflammation in the body.
In conditions such as psoriasis, psoriatic arthritis, and ankylosing spondylitis, the immune system becomes overactive, leading to chronic inflammation. By inhibiting IL-17A, Cosentyx helps to reduce this inflammation and provide relief to patients suffering from these debilitating conditions.
The mechanism of action of Cosentyx is not limited to these specific conditions. Recent research has shown that it may also be effective in the treatment of non-radiographic axial spondyloarthritis and moderate-to-severe plaque psoriasis. These findings highlight the versatility of Cosentyx and its potential to address a wide range of inflammatory conditions.
Common Uses of Cosentyx.
Cosentyx has been approved by regulatory bodies for the treatment of various conditions. Let's take a closer look at some of its most common uses.
Psoriasis:. Psoriasis is a chronic skin condition characterized by red, itchy patches of skin covered with silvery scales. Cosentyx has been found to be highly effective in reducing the symptoms of moderate-to-severe plaque psoriasis. Clinical trials have shown significant improvement in skin clearance and reduced itchiness in patients treated with Cosentyx.
Psoriatic Arthritis:. Psoriatic arthritis is a type of arthritis that affects some individuals with psoriasis. It causes joint pain, swelling, and stiffness. Cosentyx has been approved for the treatment of psoriatic arthritis and has shown remarkable results in reducing joint inflammation and improving physical function in patients.
Ankylosing Spondylitis:. Ankylosing spondylitis is a chronic inflammatory disease that primarily affects the spine. It causes stiffness, pain, and limited mobility. Cosentyx has been proven to be effective in reducing the signs and symptoms of ankylosing spondylitis, including spinal pain and inflammation.
Uncommon Uses of Cosentyx.
While Cosentyx is most commonly used to treat psoriasis, psoriatic arthritis, and ankylosing spondylitis, researchers have explored its potential in addressing other conditions as well. Although these applications are still being investigated, early findings are promising.
Non-Radiographic Axial Spondyloarthritis:. Non-radiographic axial spondyloarthritis is a condition that causes chronic inflammation in the spine without visible structural damage on X-rays. Recent studies suggest that Cosentyx may be beneficial in reducing inflammation and improving symptoms in patients with non-radiographic axial spondyloarthritis. Further research is needed to confirm these findings.
Moderate-to-Severe Plaque Psoriasis:. While Cosentyx is primarily used for moderate-to-severe plaque psoriasis, it has also shown potential in treating other forms of psoriasis. This includes guttate psoriasis, pustular psoriasis, and erythrodermic psoriasis. Clinical trials are ongoing to evaluate the efficacy of Cosentyx in these specific subtypes of psoriasis.
Side Effects of Cosentyx.
Like any medication, Cosentyx may cause side effects in some individuals. It is essential to be aware of these potential adverse reactions and discuss them with your healthcare provider before starting treatment.

"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



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Cosentyx (secukinumab) is an immunosuppressant that reduces the effects of a chemical substance in the body that can cause inflammation.

Cosentyx is used to treat moderate to severe plaque psoriasis (raised, silvery flaking of the skin), ankylosing spondylitis, and psoriatic arthritis in adults.

Dr. Reyes discusses abstract #1835 presented at the ACR21 annual meeting.

Secukinumab review.
Generic name: secukinumab.
Brand name: Cosentyx.
Dosage form: injection, intravenous infusion.
Drug class: Interleukin inhibitors.

What is secukinumab?


Secukinumab (Cosentyx) is used to treat types of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis, which are autoimmune conditions. Cosentyx is an immunosuppressant medicine that reduces the effects of a chemical substance in the body that can cause inflammation.

Secukinumab is from a group of medicines called interleukin (IL) inhibitors, and works by blocking the activity of a protein called IL-17A. People who have autoimmune conditions have increased levels of this protein. By blocking the protein's activity, it reduces inflammation, pain, swelling, and skin symptoms that you may have.

Secukinumab is available as a subcutaneous injection (an injection under the skin) and as an intravenous (IV) formulation.


What is secukinumab used for?


Secukinumab is FDA approved to treat:

moderate to severe plaque psoriasis in patients 6 years and older who are candidates for systemic therapy or phototherapy.
active psoriatic arthritis (PsA) in patients 2 years of age and older.
adults with active ankylosing spondylitis.
adults with active non-radiographic axial spondyloarthritis (nr-axSpA) and objective signs of inflammation.
active enthesitis-related arthritis (ERA) in patients 4 years of age and older .

This medicine may improve your psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis, and enthesitis-related arthritis, but it may also lower the ability of your immune system to fight infections.


Secukinumab side effects


Common secukinumab side effects may include diarrhea or cold symptoms such as stuffy nose, sneezing, and sore throat.


How should I use secukinumab?


Use secukinumab for self-administration exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Ask your doctor or pharmacist if you don't understand how to use an injection.

If you prefer to have a healthcare provider administer Cosentyx to you, it is available as a monthly, 30-minute, intravenous infusion requiring no pre-medication and no laboratory monitoring.


Subcutaneous secukinumab.

Cosentyx for self-administration at home is injected under the skin (subcutaneous injection).

Take the injection pen out of the refrigerator and let it reach room temperature for 15 to 30 minutes before use. Give the injection within 1 hour after removing the medicine from the refrigerator. Do not try to warm the medication by heating it in a microwave, placing it in hot water, or through any other method.
Prepare an injection only when you are ready to give it. You may need to use 2 injections to get your total dose.
The solution should be clear or light-yellow. Call your pharmacist if the liquid in your vial, pen, or syringe looks cloudy, has changed colors, or has particles in it.
Do not shake the syringe or dosing pen.
The injection can be given anywhere on the front of your thighs (upper leg), upper outer arms, or abdomen (stomach) except your navel and the area 2 inches (5 centimeters) around it. Do not inject into the same place two times in a row. Avoid injecting into the skin that is hard, red, bruised, swollen, tender, or affected by psoriasis.
Throw away a prefilled syringe or injection pen after one use, even if there is still medicine left inside.
Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of them following state or local laws. Keep out of the reach of children and pets.

You may get infections more easily, even serious infections. You will need frequent medical tests.


Dosing information.


Your dosage of secukinumab depends on which condition you are treating, your age, weight and sometimes how well your treatment is responding to treatment. If you have a loading dose you will be given a weekly dose on weeks 0, 1, 2, 3 and 4 and then have injections every 4 weeks. If you do not have a loading dose your injections will be every 4 weeks.