Metoclopramide is a medication used primarily as an antiemetic (to prevent nausea and vomiting) and as a prokinetic agent (to enhance gastrointestinal motility). Here are some key points about its pharmacology:

Mechanism of Action
Dopamine D2 Receptor Antagonist: Metoclopramide blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain, which helps prevent nausea and vomiting.

Prokinetic Agent: It enhances the response to acetylcholine in the upper gastrointestinal tract, increasing gastric emptying and lower esophageal sphincter tone without stimulating gastric, biliary, or pancreatic secretions.

Indications
Nausea and Vomiting: Used to treat nausea and vomiting associated with chemotherapy, radiation therapy, and postoperative recovery.

Gastroesophageal Reflux Disease (GERD): Helps in treating GERD by increasing lower esophageal sphincter pressure.

Diabetic Gastroparesis: Used to treat delayed gastric emptying in diabetic patients.

Administration
Oral: Tablets, orally disintegrating tablets (ODT), and oral solution.

Intravenous (IV): Administered as an IV infusion.

Intramuscular (IM): Administered as an IM injection.

Dosage
Nausea and Vomiting: Typically 10 mg orally or 2 mg/kg IV/IM.

GERD: Dosage varies based on the severity of symptoms and patient response.

Side Effects
Common: Drowsiness, dizziness, and fatigue.

Serious: Extrapyramidal symptoms (e.g., acute dystonia, akathisia, parkinsonian features), tardive dyskinesia (with long-term use), and hyperprolactinemia.

Precautions
QT Prolongation: Monitor for prolonged QT interval, especially in patients with a history of heart conditions.

Renal and Hepatic Impairment: Dosage adjustments may be necessary for patients with severe renal or hepatic impairment

#Metoclopramide

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Metoclopramide injection / Prokinetics/ injection Perinorm uses in hindi
Metoclopramide is a very commonly used antiemetic used in general practice. It is a prokinetic. It has an important side effect of extrapyramidal symptoms which can be easily managed by using certain drugs.
In this video I have explained
1)mechanism of action of metoclopramide
2)uses of metoclopramide
3)doses of metoclopramide
4)side effects of metoclopramide
5)interactions of metoclopramide
6)extrapyramidal symptoms management.
If you have any query on this topic then ask me in comment box
THIS VIDEO IS FOR EDUCATION PURPOSE ONLY.
TAKE TREATMENT UNDER CONSULTATION OF YOUR DOCTOR ONLY.
#metoclopramide #antiemetics #prokinetics #pharmacology #pharmacologylectures #pharmacologylecture #fundamedical

This medication, is not good ! This medication may work for certain people ! But didn’t work well at all for me but made my problems worst !!!! And all the doctors act like this medication couldn’t have caused this or that they don’t know ! That this medication could cause these things ! Check out this video ! If you’ve had any of these things happen to you it’s definitely the medication ! 💯 Pray For better days hold on tight ! You will be fine !

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Uses of metoclopramide are:
Anesthesia: To prevent aspiration
Partial but not in a complete bowel obstruction
Chemotherapy – induced N/V – given prophylactically
Functional dyspepsia
Gastroparesis in DM and non – DM
Hiccups
Analgesic Induced headache
Severe migraine
Status migrainosus
Nausea
Vomiting
Palliative care
Hyperemesis gravidarum
Vertigo
GERD
Radiation and N/V
Tension headache

There are certain contra-indications,like:
Hypersensitivity
Angioedema
Bronchospasm
GIT obstruction
GIT perforation
Pheochromocytoma
Epilepsy
TD/ Akathisia/ NMS
Infants less than 1 year old = in some centers

And many more pieces of info,enjoy listening!

Morning Sickness refers to the feeling of nausea most women experience during the first trimester of pregnancy. Caused by increased levels of the hormone produced by the body to support the pregnancy. Most women experience nausea and vomiting during the first trimester. Around 85 percent of women experience nausea, while 60 to 70 percent experience vomiting as symptoms of morning sickness.

Although nausea and vomiting is mostly experienced in the morning, therefore its name, it may persist throughout the day and be triggered by different experiences like; odors, tastes, movements etc.
The best treatment for morning sickness, nausea and vomiting involves prevention. What are some tips to avoid feeling sick in the first trimester?

Eat small meals throughout the day, starting before getting out of bed. Avoiding an empty stomach can prevent nausea. Eat saltine crackers 10 to 15 minutes before getting out of bed
Drink small amounts of fluids throughout the day to avoid dehydration. Sports drinks, like Gatorade, help.
Drink fluids 30 minutes before and after meals, instead of with the meal
Add raw ginger to your meals and drinks
The smell of lemon, drinking lemonade or lemon water, or other lemon flavored drinks with ginger may settle your stomach.

What medications can be used in the first trimester?
Diclegis : Vitamin B6 25 mg & Doxylamine 25 mg (unisom)
Ondansetron - Zofran
Metoclopromide - Reglan

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