-Dr Myeong-Ki Hong (Yonsei University College of Medicine, KR) outlines the late-breaking results from the LODESTAR trial (NCT02579499).

LODESTAR (Yonsei University) was a randomized, open-label multicenter trial that aimed to compare the clinical efficacy and safety of atorvastatin vs rosuvastatin for the secondary prevention of coronary artery disease. 4400 coronary artery disease patients were enrolled in the trial and were randomized to receive either high-potent statin therapy or LDL-C goal statin therapy.

Previously, no data had compared results in patients treated with atorvastatin to those who had been treated with rosuvastatin. Results suggest that clinical outcomes were similar between both groups of patients. Rates of LDL-C were significantly lower in the rosuvastatin group, but this drug also carried a higher risk of new-onset diabetes compared to atorvastatin treatment.

Questions:
-What is the importance of this study?
-What do the current guidelines, specifically the 2013 ACC/AHA guideline recommend?
-What was the study design and the baseline characteristics of the patients?
-What were the key findings presented at ESC?
-What are the benefits of the treat-to-target strategy?
-What are take-home messages for patient care?
-How should these results influence guidelines?

Recorded on-site at ESC Congress 2023, Amsterdam.

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It almost didn’t exist! Lipitor: The Story Behind the $12 Billion Popular Cholesterol Drug.

If you’d like to learn more about Atorvastatin, watch this video: https://youtu.be/_IFrhRMhxJY

⌛ Video outline:
0:00 Lipitor: A Top-Selling Drug Success Story

ℹ️ Disclosure: None. This is not a sponsored video.

⚠️ Warnings and Precautions:
Before starting atorvastatin, patients should inform their healthcare provider if they have liver or kidney problems, muscle pain or weakness, thyroid issues, a history of alcohol abuse, are pregnant or breastfeeding, or are older than 65 years.

ℹ️ References:
🔗 https://theconversation.com/we....ekly-dose-lipitor-th
🔗https://www.businessinsider.co....m/lipitor-the-best-s

⚠️ Disclaimer: These videos are intended for pharmacists. If you’re not a pharmacist and want to learn more about this topic, ask your pharmacist! If you are a pharmacist, always use your own professional judgment and consult any other necessary or appropriate sources prior to making clinical judgments. The information in this video is as current as when it was published. I do not own the rights to any of the images within this video.

Thoughts or topic suggestions? Leave a comment. Thanks for watching!

============================================================
#atorvastatin #Lipitor #highcholesterol #statin #hearthealth #medication #healthcare #pharmacy #turbostatin

"atorvastatin," "Lipitor," "high cholesterol," "statin drug," "heart health," "cardiovascular disease," "muscle pain," "side effects," "drug interactions," "medication guide"

"How does atorvastatin work?"
"What are the side effects of atorvastatin?"
"Can I take atorvastatin with other medications?"
"Is it necessary to take atorvastatin at night?"
"What is the best way to take atorvastatin?"
“History of Lipitor”
“What is lipitor”

===========================================================

Atorvastatin (Lipitor) – Side Effects, Uses, Mechanism of Action, Dosage, Interactions, Warnings
Atorvastatin, commonly known under the brand names Lipitor, Caduet, and Atorvaliq, is a statin medication used to lower cholesterol and triglyceride levels, thereby reducing the risk of heart attack and stroke in individuals with type 2 diabetes or coronary heart disease. It works by inhibiting HMG-CoA reductase, an enzyme in the liver responsible for cholesterol production, thus decreasing low-density lipoprotein (LDL) cholesterol and increasing high-density lipoprotein (HDL) cholesterol. Common side effects include muscle and joint pain, nasopharyngitis, nausea, and diarrhea, while serious but rare side effects can include myopathy, rhabdomyolysis, liver enzyme abnormalities, and increased blood sugar levels. Dosages for adults typically range from 10 to 80 mg once daily, with children aged 10-17 years recommended to start at 10 mg once daily, not exceeding 20 mg. Atorvastatin can interact with other cholesterol-lowering medications, certain antibiotics and antifungals, immunosuppressants, and grapefruit juice. Precautions include avoiding use during pregnancy and breastfeeding, in patients with active liver disease, and monitoring for unexplained muscle pain, tenderness, or weakness.
#atorvastatin #atorvastatinsideeffects #atorvastatinuses #lipitor #lipitorsideeffects #lipitoruses #caduet #caduetsideeffects #caduetuses #atorvaliq #atorvaliquses #atorvaliqsideeffects
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Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment.

In this video, let’s find found:
What is Atorvastatin?
What are some side effects of Atorvastatin?
Is Atorvastatin a high risk medication?
What does Atorvastatin do for a person?
Should Atorvastatin be taken in the morning or night?

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#Atorvastatin #Atorvastatin20mg #Atorvastatin40mg #Atorvastatintablet #Lipitor
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I've tried to boil down one of the most complicated topics in medicine to a YouTube length. Let's hope it worked! Statins are the most prescribed medication in the world but most of what I read and watch online is either completely vague so as to be useless, or just plain wrong.

This is one of the most requested topics I get, and while not the most exciting, it's an important one. So I hope it helps at least one person make a decision.

I wanted to keep it short to ensure people actually watched - an in-depth lecture would of course have offered the chance to really dive into the details but my objective here is to help as many people as possible.

If you find statins confusing, you're not alone! Cardiologists and GPs probably prescribe these more often than anyone else and yet even I took a long time to really understand the enormous mass of data and coverage (which of course is impossible to read in its entirety). I want to specifically credit Professor Darrel Francis from Imperial College in London for helping me see statins in the kind of reference frame that I present in the video. Prior to that, my understanding was that kind of vague "oh this will help you, probably. I think." that you might get if you just read guidelines, which of course exist to maximise health for a whole population.

References:

https://www.thelancet.com/jour....nals/lancet/article/
https://www.thelancet.com/pdfs..../journals/lancet/PII
SAMSON n=1 study: https://www.nejm.org/doi/full/10.1056/NEJMc2031173
https://www.sciencemediacentre.....org/expert-reaction


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Fifty-six million Americans fall under the guidelines to take a statin to reduce cholesterol, but a new study says only about half take them. Many start the medication, but abandon it after two years. The study highlights the dangers of ending statin therapy, including heart attacks and death. Dr. Tara Narula joins "CBS This Morning" to discuss why people stop taking the medicine, the risks of abandoning the medication and misconceptions associated with the drug.

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This video looks at fatal Atorvastatin side effects and common Atorvastatin side effects. This video explores most common questions asked about Atorvastatin and its side effects especially when potentially fatal especially in older adults.It also looks at Atorvastatin use with alcohol, grapefruit and muscle pains.

It also explores commonly asked questions such as What is Atorvastatin? , Why is my doctor recommending Atorvastatin? , How does it work ?, How should I take Atorvastatin? , What happens if i miss a dose?, What should I avoid while taking Atorvastatin?, What are possible other drugs that can effect Atorvastatin?. Who should ABSOLUTELY NOT take this drug?, What are common side effects?, What are serious side effects?, Can the elderly take Atorvastatin?

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READ COMPLETE TRANSCRIPT AND ARTICLE HERE: https://drthinkyourhealth.com/....atorvastatin-side-af

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WATCH NEXT:
https://youtu.be/Cvr2_jxXtao ( Can Statins cause muscle injury?)

https://youtu.be/fPin3XABBy8 (Pravastatin side effects)

https://youtu.be/Qa6m-zmRvV4 (Rosuvastatin surprising facts!)

https://youtu.be/MmVdZjsf92U ( Statins and muscle pain)



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Sources:

1)Uptodate.com/atorvastatin
2) https://www.rxlist.com/lipitor-drug.htm
3) Choosing wisely

Think Your Health provides general educational information on various topics on this YouTube video and channel as a public service, which should not be construed as medical, psychological or health advice. These are my personal opinions only.



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Although I am a physician by profession, I am not YOUR Physician.All content and information on this YT channel including our programs, products and/or services is for informational and educational purposes only, does not constitute medical, psychological or health advice of any kind and we do not warrant that the information presented herein is free of any errors or omissions. We are not providing medical, health care, nutrition therapy or coaching services to diagnose, treat, prevent or cure any kind of physical ailment, mental or medical condition. A professional client relationship with you is only formed after we have expressly entered into a written agreement with you that you have signed including our fee structure and other terms to work with you in a specific matter.



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#Atorvastatin #Lipitor

Pharmacist explains the association between Statin medications and dementia according to data from published studies. The specific Statins that have this association will be differentiated from others and an explanation of why the body and brain need cholesterol.

Link to study in The Journal of Nuclear Medicine
https://jnm.snmjournals.org/co....ntent/62/supplement_

Link to study in Alzheimer's & Dementia
https://alz-journals.onlinelib....rary.wiley.com/doi/1

Link to Pharmacy Times Chart
https://www.pharmacytimes.com/....view/pharmacy-clinic

US Pharmacist Link
https://www.uspharmacist.com/a....rticle/some-statins-

Free stock footage by Videezy.com

The information provided in this video is intended for education and information purposes only and should not be considered as professional advice. The content presented here does not replace consultation with a physician. Please consult your doctor before making any changes to your medications. Clear & Simple Medicine LLC

Has your doctor recently prescribed you Atorvastatin or Lipitor? In this video we are going to help you understand why your doctor likely prescribed this to you and who benefits most from taking it. More importantly we are going to go over the most common side effects that you may notice as well as some of the risks that taking his medication may bring.

Medication is not the only way that you should treat your cholesterol. Many times through lifestyle changes like diet and exercise you can make a big impact on controlling it. For some simple steps you can start with in your diet watch my video on how to approach weight loss:
https://youtu.be/h1i3rT-MuTo


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Atorvastatin (Lipitor) is a statin that lowers "bad" cholesterol, raises "good" cholesterol, lowers triglycerides (TG, also known as fats). In addition, it helps protect your heart and blood vessels. Atorvastatin (Lipitor) is known as a moderate-to-high-intensity statin, meaning it lowers your cholesterol more so than many other statins. And as with all statins, atorvastatin (Lipitor) can cause rare, but serious side effects, such as liver problems or severe muscle pain. It's important that you eat a healthy diet and exercise regularly in order to get the most benefits from this medication.

Save on this medication: https://goodrx.co/AtorvastatinCoupon
Learn more: https://goodrx.co/RxGuideAtorvastatin

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*Захід призначений виключно для працівників сфери охорони здоров'я

СПІКЕР:
Зозуля Іван Савович (д.мед.н., професор кафедри медицини невідкладних станів НУОЗ України імені П.Л. Шупика, академік АН Вищої Освіти України, заслужений діяч науки і техніки України, дійсний член Нью-Йоркської Академії Наук, Лауреат Державної премії України в галузі науки і техніки, дійсний член Європейської Асоціації природознавства).

МЕТА ЗАХОДУ:
Надати лікарям актуальну доказову інформацію щодо тактики ведення пацієнтів з неврологічними та психічними захворюваннями, адаптовану до сучасних реалій в умовах війни, з особливим акцентом на розборі клінічних випадків, в тому числі зі складним діагностичним пошуком, продемонструвати нові досягнення медицини в лікуванні та реабілітації пацієнтів, забезпечити умови для обміну досвідом між медичними працівниками та науковцями для опанування практикуючими лікарями професійних знань та навичок щодо ефективного лікування пацієнтів.

АКТУАЛЬНІСТЬ:
Ураження нервової системи на різних рівнях часто призводить до хронічного перебігу захворювання, що потребує тривалого медичного супроводу, адаптації терапевтичних підходів та впровадження нових стратегій для покращення якості життя пацієнтів. Такі захворювання, як інсульт, розсіяний склероз, хвороба Паркінсона, міастенія, деменція тощо, супроводжуються високим ризиком інвалідизації та функціональної залежності пацієнтів від сторонньої допомоги. Постійне оновлення міжнародних клінічних рекомендацій підкреслює необхідність володіння сучасними знаннями та практичними навичками серед лікарів.
У нинішніх умовах війни особливої гостроти набули захворювання та стани, спричинені тривалим стресом, психологічною травмою, тривогою та втратою. Значне зростання випадків ПТСР, депресії, панічних атак, тривожних і обсесивно-компульсивних розладів серед військових і цивільного населення різного віку, часто з коморбідною патологією, вимагає міждисциплінарного підходу до діагностики, лікування та тривалої реабілітації.

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In this video we will cover everything you need to know about Atorvastatin, also known as Lipitor. We will discuss how and when to use it, we will cover its side effects, dosage and much, much more.

You can find more useful videos on cardiovascular diseases and their treatments here:
https://www.youtube.com/playli....st?list=PLaG3Bo3L0gX

Generic name: Atorvastatin.
Brand names: Lipitor.
Available as tablets and chewable tablets.

How to use it?
- Tablet: just swallow it whole with half a glass of water.
- Chewable tablet: just take the tablets and chew on it until it dissolves. If you want to you can also swallow this tablet whole.
It is best to take this medicine at fixed times. This will make you less likely to forget a dose.

When to use it?
Atorvastatin is part of a group of drugs called Statins. They inhibit the enzyme HMG-CoA reductase, which normally plays an essential role in the synthesis of cholesterol in the liver. This lowers the circulating LDL, the total cholesterol and increased HDL-cholesterol.
Therefore Atorvastatin can be used to treat a high cholesterol, familial hypercholesterolemia and it can be used to prevent cardiovascular disease.

What is the correct dosage?
The precise dose will depend on your specific indication of use, the side effect you might experience and the severity of your symptoms. Therefore always use the precise amount and frequency your doctor prescribed you.
- However, when treating adults most doctors will start with an initial dose of 10 mg 1x per day. Which if necessary, at intervals, can be increased to max. 80 mg 1x per day.

What are the side-effects?
- Common: Sore throat, nosebleed, allergic reaction, diarrhea, flatulence, nausea, constipation, joint pain, backache, muscle spasms, high blood glucose and headache.
- Uncommon: Fever, Malaise, Edema, Chest pain, Fatigue, Hair loss, Rash, Itching, Hepatitis, Vomiting, Abdominal pain, Belching, Weight gain, Tinnitus, Nightmares, Insomnia, Muscle fatigue, Muscle weakness, Low blood sugar, Dizziness and Taste disorders.
- Rare: it can cause several severe side effects.

Safety:
- First of all it is safe to drive when using atorvastatin.
- However, it rarely can cause liver abnormalities which can be increased with consumption of too much alcohol. Therefore it is often advised to not drink or at most 1 glass a day while using atorvastatin.
- In addition do not drink grapefruit juice, as this enhances the effect of atorvastatin, which can cause side effects.
- Furthermore, atorvastatin can have interactions with other drugs your are taking. always discuss this with your prescribing doctor.
- Lastly, do not use atorvastatin while pregnant or while breastfeeding, as it can be dangerous.

- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -

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- Sebastian Houwing: Investor

Literature:
1: Farmacotherapeutisch Kompas. (2022). Atorvastatine.
2: Apotheek.nl (2022). Atorvastatine.

* The images in this video are used for educational purposes only. Most of the images and videos in this video come from https://www.canva.com/.

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