Colchicine Side Effects


A recent study in the journal Rheumatology has found that Colchicine use may lower the risk of chronic kidney disease (CKD) progression, chronic kidney disease progression was defined as morethan or equal to 40% decrease from the baseline estimated glomerular filtration rate or the onset of kidney failure with replacement therapy.
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![ALLOPURINOL (Zyloric / Zyloprim) for GOUT | Common doses, side effects [Educational video]](https://i.ytimg.com/vi/b-nkJhvQOCo/maxresdefault.jpg)

In this video Doctor O'Donovan explains key facts about a medication called ALLOPURINOL and how it is used to treat a condition called GOUT - where uric acid crystals build up in the joints.
Allopurinol is also know by its trade or brand names: Zyloric, Uricto or Zyloprim.
In the video we cover:
00:00 Introduction
00:43 What is allopurinol (Zyloprim)?
01:06 Who can and can't take allopurinol?
01:49 How to take allopurinol?
03:24 Side effects of allopurinol
05:43 - Advice if pregnant
06:13 - Taking allopurinol with other medications
Key facts from the NHS:
*Allopurinol reduces the amount of uric acid made by your body's cells. *This reduces symptoms such as swollen and painful joints (gout).
*It may take several months before you feel the full benefit of allopurinol.
*During the first few months of treatment, as allopurinol starts to work, you may get more gout attacks. However, your doctor will prescribe non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine to help with this.
*When allopurinol is taken regularly, it can lower the number of gout attacks and help prevent damage to the joints.
*Usually you will start allopurinol after an acute attack of gout has completely settled.
Further information:
https://www.nhs.uk/medicines/allopurinol/
https://bnf.nice.org.uk/drugs/allopurinol/
https://www.mayoclinic.org/dru....gs-supplements/allop
#doctor #gout #medication #pharmacy #health #healthcare #goutrelief #zyloprim
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This video has been designed for EDUCATIONAL purposes ONLY and is NOT intended to promote or advertise any prescription-only medication.
Disclaimer:
The video is intended as an educational resource only. The information within this video or on this channel isn't designed to replace professional input, so if you have any medical issues please consult a medical provider. No professional relationship is being created by watching this video. Dr. O’Donovan cannot give any individual medical advice. All information should be verified for accuracy by the individual user. Dr O’Donovan accepts no responsibility for individual interpretation of data, although it is always accurate to the best of his knowledge at the time of the video being published. Dr. O'Donovan does not endorse or promote any medication discussed in this video. Images are used in accordance with fair use guidelines.
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Visit this website to do so: https://yellowcard.mhra.gov.uk


I cover Colchicine (Colcrys) pharmacology, adverse effects, and drug interactions.
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How To Take Colchicine For Acute Gout? Managing acute gout can be challenging, especially when it comes to understanding the proper use of medication like colchicine. In this informative video, we will guide you through the essential steps for taking colchicine effectively. We will cover the recommended dosages, how to adjust your intake based on different tablet strengths, and the importance of adhering to your doctor's instructions. Additionally, we will discuss potential side effects and what to do if you miss a dose or accidentally take too much.
Understanding the timing between treatment courses is also vital, and we will explain why waiting three days before starting another course is necessary. By following these guidelines, you can manage your gout symptoms while minimizing any risks associated with the medication.
Whether you are new to colchicine or looking to refresh your knowledge, this video will provide you with the information you need. Remember, always consult with your healthcare provider if you have any questions or concerns regarding your treatment.
Join us for this important discussion, and don’t forget to subscribe to our channel for more helpful content on pain management and medicine.
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#GoutManagement #Colchicine #PainRelief #GoutAttack #MedicationGuide #HealthTips #ChronicPain #PainManagement #GoutSymptoms #DosageInstructions #SideEffects #HealthcareAdvice #PatientEducation #WellnessJourney #DoctorAdvice
About Us: Welcome to Pain Medicine Network, your trusted source for comprehensive information on pain management and treatment options. Our channel is dedicated to exploring the latest advancements in pain medicine, offering insights into innovative therapies, research breakthroughs, and expert interviews.
Please note that our content is purely informational and should not be considered medical advice. Always consult a healthcare professional for personalized guidance and do your own due diligence when it comes to your health and treatment options. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.


Inder Birdi, top heart surgeon, interviews world leading Interventional Cardiologist Dr Jonathan Clague to learn more about what doctors can do for patients with cardiovascular risk who do not tolerate statins, or in whom statins do not effectively lower cholesterol (especially the bad LDL cholesterol).
Injectable cholesterol lowering agents such as Repatha (Evolocumab) are gaining traction as effective alternatives in patients who suffer side effects to statins or if statins do not work.
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Study this Colchicine NCLEX mnemonic and other mnemonics with Pixorize.
Colchicine is an anti-inflammatory medication that is used to reduce inflammation, treating acute gout attacks and pericarditis. The biggest side effect to know is gastrointestinal distress. Colchicine may be taken with food to relieve GI discomfort.
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Are Colchicine Side Effects Normal For Gout Treatment? In this informative video, we will discuss the side effects associated with colchicine, a medication commonly used for managing gout. Understanding these side effects is essential for anyone considering or currently using colchicine as part of their treatment plan. We will cover the most frequently reported side effects, particularly those related to the gastrointestinal system, and provide tips on how to manage them effectively.
It's important to be aware that while many side effects are mild, some can be serious and may require immediate medical attention. We'll highlight the signs to watch for and the importance of adhering to prescribed dosages. Regular monitoring through blood tests may also be necessary to ensure your safety during treatment.
If you or someone you know is dealing with gout and considering colchicine, this video is a must-watch. We will also provide guidance on how to communicate with healthcare providers about any concerns or side effects experienced during treatment. Remember, managing gout effectively involves understanding both the benefits and potential risks of the medications used.
Join us in this essential discussion, and subscribe to our channel for more helpful information about gout management and treatment options.
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#Gout #Colchicine #GoutTreatment #GoutRelief #MedicationSideEffects #HealthTips #ChronicPain #JointHealth #GastrointestinalHealth #PatientEducation #Healthcare #MedicalAdvice #GoutAwareness #Wellness #HealthyLiving #MedicationManagement
About Us: Welcome to Gout Relief Guide! Our channel is dedicated to helping you understand and manage gout through informative discussions on crucial topics such as gout symptoms and flare-ups, causes of gout, uric acid levels, gout-friendly diets, foods to avoid with gout, gout medications, managing gout pain, chronic gout management, natural remedies for gout, and preventing gout attacks. We aim to provide relatable and practical advice for your gout management journey. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.


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"This video provides educational content for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider with any questions regarding a medical condition or treatment. We do not endorse any specific treatments, medications, or products discussed on this channel."
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Contributor: Don Stader, MD
Educational Pearls:
1. Gout is an arthritis caused by the deposition of urate crystals into the joint space
2. Colchicine works by disrupting microtubules and prevents white blood cells from getting into the joint space which stops the inflammatory response
3. Colchicine has a high rate of adverse events, in particular explosive diarrhea
4. The drug also has a very narrow therapeutic index and overdose is nearly universally fatal, with no antidote or effective treatment option available
5. Alternative agents such as steroids, which reduce the inflammatory response to urate crystals, along with NSAIDs may be better options for treatment
References
Angelidis C, Kotsialou Z, Kossyvakis C, et al. Colchicine Pharmacokinetics and Mechanism of Action. Curr Pharm Des. 2018;24(6):659-663. doi:10.2174/1381612824666180123110042
Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48(5):407-414. doi:10.3109/15563650.2010.495348
Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388(10055):2039-2052. doi:10.1016/S0140-6736(16)00346-9
Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD
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Cathy covers medications used to treat gout. An acute gout medication (colchicine) is discussed, as well as chronic gout medications (probenicid and allopurinol).
Our Pharmacology video tutorial series is taught by Cathy Parkes BSN, RN, CWCN, PHN and intended to help RN and PN nursing students study for their nursing school exams, including the ATI, HESI and NCLEX.
#NCLEX #Pharmacology #gout #HESI #Kaplan #ATI #NursingSchool #NursingStudent #Nurse #RN #PN #Education #LVN #LPN #Chronic
0:00 What to Expect
0:10 Colchicine & Mode of Action
0:32 Side Effects & Patient Teaching
1:40 Probenecid & Mode of Action
2:02 Side Effects & Patient Teaching
2:43 Allopurinol
2:58 Mode of Action
3:11 Side Effects
3:22 Patient Teaching
3:56 What’s Next?
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Colchicine is an alkaloid used to treat gout and Familial Mediterranean Fever as well as prevent major cardiovascular events.
In this video, let’s find found:
What is colchicine?
What is colchicine used for?
Contraindication
What are the side effects of taking colchicine?
How does colchicine work?
How to use colchicine?
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#colchicine #gout #Colcrys
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Tags: he-info, colchicine, colchicine uses, colchicine dosage, colchicine side effects, colchicine mechanism, colchicine indication, colchicine contraindications, colchicine mechanism of action, gout, gout medication, Behçet's disease, colchicine tablets, colchicine 0.6 mg, colchicine 0.5 mg, colchicine 500mcg, colchicine alkaloid, pericarditis, familial Mediterranean fever, Colcrys, Mitigare, colchicine 1 mg, Gloperba, Lodoco, postpericardiotomy syndrome, myocardial infarction, Antigout Agents


What Are The Long-term Effects Of Colchicine? In this informative video, we will discuss the long-term effects of colchicine, a medication commonly used to treat gout and other inflammatory conditions. We'll begin by outlining how colchicine works in the body and its role in managing inflammation. Understanding the potential side effects is important for anyone considering this medication, especially for long-term use.
We will cover both common and serious side effects associated with colchicine. While gastrointestinal issues such as diarrhea and nausea are frequent, there are also rare but serious concerns like rhabdomyolysis and neuromyotoxicity. We will explain what these conditions entail and their implications for your health. Additionally, we’ll address the lack of evidence linking colchicine to increased risks of kidney disease, cancer, sepsis, or blood disorders.
Monitoring your health while on colchicine is essential, particularly for those with existing health conditions. We encourage you to consult with a healthcare provider to ensure safe and effective management of your treatment. Stay informed and proactive about your health decisions.
Join us for this important discussion, and subscribe to our channel for more helpful information about medications and health management.
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#Colchicine #GoutTreatment #AntiInflammatory #MedicationSafety #LongTermEffects #HealthMonitoring #Rhabdomyolysis #Neuromyotoxicity #GastrointestinalIssues #ChronicConditions #Inflammation #HealthcareProvider #PatientEducation #MedicationManagement #HealthAwareness
About Us: Welcome to Pharmaceutical Insights! Our channel is dedicated to providing clear and informative content on a variety of topics related to pharmaceutical drugs, prescription medications, over-the-counter medicines, drug side effects, and medication safety. We also discuss medical treatments, alternative medicine, and pain management drugs, ensuring you have access to the information you need to make informed health decisions. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.


Read the research: https://doi.org/10.3399/BJGP.2022.0083
In this 1-minute video, Prof. Christopher C Butler explains:
– Colchicine is used regularly for treating gout
– Side effects are gastrointestinal; it is an anti-inflammatory
– Results were available quickly due to the trial design
– Colchicine did not speed up recovery from COVID-19
– The PRINCIPLE trial gives rapid answers within the pandemic
– Trial design is flexible, adapting to different treatments
– PRINCIPLE is transforming research in primary care
Listen to the full podcast interview: https://player.captivate.fm/ep....isode/63de9c41-84f2-


COLCHICINE Tablets For The GOUT Treatment
Colchicine is a medicine which is used in the Gout treatment. In this video, we cover the colchicine gout treatment, colchicine side effects, colchicine for gout, Colchicine mechanism of action and drug interactions. Colchicine 0.6 mg and colchicine 0.5 mg tablets, which are available in the market, are the most popular dosage former of the medication.
Do you suffer from gout or other inflammatory conditions? Colchicine might be the solution you've been looking for. This medication has been used for centuries to treat a variety of conditions, and its benefits are well-known in the medical community.
Colchicine works by reducing inflammation in the body, which can help alleviate pain and discomfort. It is especially effective in treating gout flare-ups, as well as other inflammatory conditions like familial Mediterranean fever.
One of the key benefits of Colchicine is its ability to help prevent future gout attacks. By taking this medication as prescribed, you can reduce the frequency and severity of flare-ups, allowing you to live a more comfortable and active lifestyle.
It's important to note that Colchicine should only be taken as directed by your healthcare provider. Be sure to follow their instructions carefully and inform them of any other medications you are taking.
If you suffer from gout or other inflammatory conditions, talk to your doctor about whether Colchicine could be right for you. It could make a world of difference in managing your symptoms and improving your quality of life.
#colchicine #gout #inflammation #arthritis #health #wellness #painrelief #treatment #medication #naturalremedies #holistichealth #antiinflammatory #chronicpain #pharmacy #medicine #arthritisawareness #healthyhabits #supplements #prevention #doctor
Chapters:
00:00:00 "Gout and Its Impact on Health"
00:01:00 "Introduction to Colchicine"
00:01:32 "Mechanism of Action of
Colchicine"
00:02:29 "Side Effects and Drug Interactions of Colchicine"
00:03:57 "Dosage Forms and Key Points about Colchicine"
00:05:03 "Conclusion"
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Colchicine na gamot sa gout, posibleng mapababa ang komplikasyon o tsansang mamatay sa COVID, ayon sa Montreal Heart Institute
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PHILADELPHIA -- Low dose colchicine (Colcrys) appears to be as effective as high doses of the drug in reducing the pain of gout with fewer advers side effects, a researcher said here.
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#shorts
If you’re experiencing uncomfortable side effects while treating gout, let’s chat about alternatives.
As a gout pain expert, I’m here to help you find relief. Join our Got Gout group on Facebook for more tips and support.
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PHARMACIST Fi shares 7 Top Tips to help you try to avoid colchicine toxicity side effects (such as diarrhea, nausea, vomiting, stomach or intestine area pain, throat pain, etc.) - which are thankfully much less common now that a lot of doctors are prescribing
*modern, smaller dose schedules for acute gout flare treatment,
*lower colchicine dose schedules for people with kidney or liver problems, and
*managing serious interactions with certain types of other medicines - by either stopping colchicine or significantly reducing the colchicine dose schedule (depending on which medicine is interacting with colchicine).
Here is the link to PHARMACIST Fi's video about potential colchicine side effects and medicine interactions to avoid: https://youtu.be/deO0BMqNwWM
It is also important to remember to:
*avoid eating grapefruit and avoid drinking grapefruit juice while taking colchicine
*never take more colchicine than the doctor advises to take, and
*only take colchicine if it has been prescribed for you and don't give your colchicine to other people (because some people must not take colchicine due to some types of medical conditions, or potentially lethal medicine interactions with certain types of medicines).
If the doctor's instructions about how to take colchicine could be interpreted more than one way, or if you forget exactly how the doctor advised to take colchicine, as soon as possible, ask your doctor:
*how much colchicine to take per dose, and
*how much time to leave between colchicine doses, and
*whether or not there is a date that you need to stop taking colchicine (this will depend on whether the aim is to treat an acute gout flare, or to try to prevent future gout flares - because the colchicine dose schedules for these 2 different aims are likely to be quite different).
Here is the link to PHARMACIST Fi's video 'Ways to Avoid Accidentally Taking Too Much of a Medicine': https://youtu.be/zxucLmKicOc
&
Here is the link to PHARMACIST Fi's video 'Ways to Avoid Forgetting to take Medicines': https://youtu.be/e_UWtmuDfuM
Here is the link to PHARMACIST Fi's 'Colchicine Part 1' video of important things to talk about with your doctor if you have been prescribed colchicine: https://youtu.be/N6jCa795bLg
Here is the link to PHARMACIST Fi's 'Gout and Medicines' playlist (including interesting new info about gout treatment in her '10 Things You May Not Know About Gout' series): https://www.youtube.com/playli....st?list=PLwyYRbsDY3j
Here is a link to the PHARMACIST Fi video about making a Medicines, Allergies & Contacts List, & what types of info about medicines to put on your Medicines, Allergies & Contacts List, so you can check it regularly before taking medicines, to try to take medicines the best way possible: https://youtu.be/6gveHPwmc9s
Colchicine brand names in the USA include: Colcrys, Mitigare, Gloperba; colchicine brand names in Australia include: Colgout, Lengout, Colcine.
INFORMATION FOR DOCTORS:
Here is a link to an example of a modern colchicine dose schedule for treatment of acute gout flare, for people with good kidney and liver function, in the 'Treatment of Gout Flares' section at the base of page 3 of the Colcrys Prescribing Information (Revised May 2020) available on the FDA website August 2023: https://www.accessdata.fda.gov..../drugsatfda_docs/lab
Please also note that for people who do have kidney impairment or liver impairment, colchicine dose schedules for treatment of acute gout flare are in the 'Treatment of Gout Flares' sections on page 8 and 9, respectively, in the Colcrys Prescribing Information document above.
The Australian Medicines Handbook 2023 (https://shop.amh.net.au/products/digital) has further advice for prescribers about colchicine dose schedules and interaction management, although a subscription fee is required to access its information.
We hope this video was helpful for you.
Please also read the disclaimer at the end of the video.
If you would like to support PHARMACIST Fi to produce more of these Medicine Safety videos, please consider making a purchase from her Official Store at: https://pharmacist-fi.myshopif....y.com/collections/al ,
or making a paypal donation to PHARMACIST Fi at https://www.pharmacistfi.com/donate


Cardiologist Michelle O'Donoghue asks Paul Ridker about the dos and don'ts for the anti-inflammatory drug colchicine in patients with atherosclerotic cardiovascular disease.
https://www.medscape.com/viewa....rticle/994661?src=so
--TRANSCRIPT --
Michelle L. O'Donoghue, MD, MPH: Hi. This is Dr Michelle O'Donoghue, reporting for Medscape. Joining me today is Dr Paul Ridker. He's the Eugene Braunwald Professor of Medicine at Harvard Medical School. He's also the director of the cardiovascular prevention program at Brigham and Women's Hospital.
He's going to be joining me today to discuss a very important and emerging topic, which is the use of low-dose colchicine. I think there's much interest in the use of this drug, which now has a US Food and Drug Administration (FDA) indication, which we'll talk about further, and it's also been written into both European and American guidelines that have been recently released.
Many people are talking about where this fits into our current armamentarium, and I think there probably is no better person to discuss this than Paul Ridker, who's been at the forefront of research into anti-inflammatory therapeutics. Thank you for joining me, Paul.
Paul M. Ridker, MD, MPH: Michelle, it's a pleasure to be with you on Medscape today.
Lifestyle Lipid-Lowering Paramount
O'Donoghue: As we think about the concept behind the use of colchicine, we've obviously done a large amount of research into lipid-lowering drugs, but where does colchicine now fit in?
Ridker: Let's make sure we get the basics down. Anti-inflammatory therapy is going to be added on top of quality other care. This is not a replacement for lipids; it's not a change in diet, exercise, and smoking cessation. The new data are really telling us that a patient who's aggressively treated to guideline-recommended levels can still do much better in terms of preventing heart attack, stroke, cardiovascular death, and revascularization by adding low-dose colchicine as the first proven anti-inflammatory therapy for atherosclerotic disease.
I have to say, Michelle, for me, it's been a wonderful end of a journey in many ways. This story starts almost 30 years ago for quite a few of us, thinking about inflammation and atherosclerosis. The whole C-reactive protein (CRP) story is still an ongoing one. We recently showed, for example, that residual inflammatory risk in some 30,000 patients, all taking a statin, was a far better predictor of the likelihood of more cardiovascular events, in particular cardiovascular death, than was residual cholesterol risk.
Think about that. We're all aggressively giving second lipid-lowering drugs in our very sick patients, but that means inflammation is really the untapped piece of this.
The two clinical trials we have in front of us, the COLCOT trial and the LoDoCo2 trial — both New England Journal of Medicine papers, both with roughly 5000 patients — provide very clear evidence that following a relatively recent myocardial infarction (that's COLCOT) in chronic stable atherosclerosis (that's LoDoCo2), we're getting 25%-30% relative risk reductions in major adverse cardiovascular events (MACEs) on top of aggressive statin therapy. That's a big deal. It's safe, it works, and it's fully consistent with all the information we have about inflammation being part and parcel of atherosclerosis. It's a pretty exciting time.
Inflammatory Pathway
O'Donoghue: It beautifully proves the inflammatory hypothesis in many ways. You led CANTOS, and that was a much more specific target. Here, in terms of the effects of colchicine, what do we know about how it may work on the inflammatory cascade?
Ridker: Our CANTOS trial was proof of principle that you could directly target, with a very specific monoclonal antibody, a specific piece of this innate immune cascade and lower cardiovascular event rates.
Colchicine is a more broad-spectrum drug. It does have a number of antineutrophil effects — that's important, by the way. Neutrophils are really becoming very important in atherosclerotic disease progression. It's an indirect inhibitor of the so-called NLRP3 inflammasome, which is where both interleukin (IL)-1 (that's the target for canakinumab) and IL-6 are upregulated. As you know, it's been used to treat gout and pericarditis in high doses in short, little bursts.
The change here is this use of low-dose colchicine, that's 0.5 mg once a day for years to treat chronic, stable atherosclerosis. It is very much like using a statin. The idea here is to prevent the progression of the disease by slowing down and maybe stabilizing the plaque so we have fewer heart attacks and strokes down the road.
It's entering the armamentarium — at least my armamentarium — as chronic, stable secondary prevention. That's where the new ACC/AHA guidelines also put it. It's really in as a treatment for chronic, stable atherosclerosis. I think that's where it belongs.
https://www.medscape.com/viewa....rticle/994661?src=so


Colchicine is a medication that is primarily used to treat gout and other inflammatory conditions. It works by reducing the inflammation and pain associated with these conditions.
Gout is a type of arthritis that occurs when there is a buildup of uric acid crystals in the joints, leading to inflammation and severe pain. Colchicine works by inhibiting the movement of certain white blood cells, called neutrophils, into the affected joint. This reduces the release of inflammatory substances and decreases the inflammatory response in the joint, thereby relieving pain and swelling.
Colchicine is also used to prevent gout attacks in individuals who have frequent episodes. It is typically taken orally, either as a tablet or capsule, and is most effective when taken at the first sign of a gout attack.
In addition to treating gout, colchicine is also used to manage other inflammatory conditions such as familial Mediterranean fever and Behçet's disease. It may also be used off-label for other conditions, such as pericarditis.
It is important to note that colchicine can have side effects, and it may interact with other medications. Common side effects include diarrhea, nausea, vomiting, and abdominal pain. In rare cases, it can cause more serious side effects, such as muscle weakness or damage, bone marrow suppression, or allergic reactions. It is important to discuss any potential risks or concerns with a healthcare professional before starting colchicine treatment.
For details please check:
https://www.glpbio.com/colchicine.html
https://www.glpbio.com/colchicine-d6.html


PHARMACIST Fi shares the fascinating ways a medicine called colchicine works to reduce inflammation for people with gout. (Some colchicine brand names you might recognize include: Colcrys, Mitigare, or Gloperba in U.S.A.; Colgout, Lengout, or Colcine in Australia.)
Please also watch PHARMACIST Fi's 3 main videos on colchicine for gout:
'Part 1' (via the following link) looks at important things for you and your doctor to talk about before starting colchicine, or when already taking colchicine:
https://www.youtube.com/watch?v=N6jCa795bLg
'Part 2' Looks at potential colchicine side effects everyone should know how to recognize and report to a doctor (although thankfully side effects are less common with modern colchicine dose schedules), and serious medicine interactions to avoid: https://youtu.be/deO0BMqNwWM
'Part 3' gives 7 Top Tips to try to avoid colchicine side effects: https://youtu.be/GSZmW8DkdTY
Here is the link to the playlist of PHARMACIST Fi videos about gout, and gout treatment medicines which may or may not be prescribed (depending on a person's other medical conditions, other medicines, and kidney and liver function levels): https://www.youtube.com/playli....st?list=PLwyYRbsDY3j
Here is the link to the PHARMACIST Fi video about CMIs (a 'CMI' is 'Consumer Medicine Information' - which is the Australian name for a Medicine Information document; in the USA this is called a 'Medication Guide', and in the UK it is called a 'Patient Information Leaflet):
https://www.youtube.com/watch?v=79CF6A5ZZ3I
Here is a link to a PHARMACIST Fi video about medicine interactions (this video has general info and is not specific to colchicine), in case it may also be of interest to you:
https://www.youtube.com/watch?v=ckRihqtel-4
We hope this info has been helpful for you!
Please also see the disclaimer at the end of this video.
If you would like to support PHARMACIST Fi to produce more Medicine Safety videos, please consider making a purchase from her Official Store at: https://pharmacist-fi.myshopif....y.com/collections/al , or making a paypal donation to PHARMACIST Fi at https://www.pharmacistfi.com/donate


PHARMACIST Fi shares serious potential side effects to report (thankfully these are now much less common with modern dose schedules), & some potentially lethal medicine interactions to avoid, for a medicine called colchicine when it is taken for gout.
If you take colchicine for a medical condition other than gout, ask a doctor for advice about the info in this video or description section, as it may or may not be suitable for your medical condition.
Here is the link to the 'Gout & Medicines' playlist, including 2 more PHARMACIST Fi videos about colchicine (scroll down the playlist to find 'Colchicine for Gout Part 1 - Things to Talk About with Your Doctor', & 'Colchicine for Gout - How Does that Work?!'), plus videos about gout, & allopurinol (allopurinol is also commonly prescribed for people with gout, if it is suitable for them): https://www.youtube.com/playli....st?list=PLwyYRbsDY3j
The active ingredients of some medicines which PHARMACIST Fi lists on screen in this video (from 5 minutes 16 seconds, to 6 minutes 33 seconds) which interact seriously with colchicine, are taken from the article at this link: https://pubmed.ncbi.nlm.nih.gov/36522578/ (pages 227-233), and the 'strong CYP3A4 inhibitors' in the interactions section of 'Australian Medicines Handbook 2023'.
Here is a list of some other active ingredients which interact with colchicine to increase toxicity risk in a similar [but hopefully less major] way to the medicines PHARMACIST Fi listed in her video -
so, if you take any of the following medicines, ask your doctor for advice before taking colchicine for gout, as you may need a colchicine dose reduction to manage the interaction
*while being treated with one of the following medicines, and
*also for 2 weeks after being treated with one of the following medicines
(needing a colchicine dose reduction to manage an interaction with one of the following medicines is even more likely if you have a kidney or liver problem; doctors can find info about colchicine dose reduction in medicine prescribing information or the Australian Medicines Handbook 2023):
azithromycin
boceprevir
carvedilol
everolimus
fluconazole (commonly used antifungal medicine)
fluvoxamine
glecaprevir with pibrentasvir
isavuconazole
ledipasvir
letermovir
osimertinib
propafenone
quinidine
ranolazine
tacrolimus
tepotinib
ticagrelor
tolvaptan
vandetanib
velpatasvir
vemurafenib
venetoclax
voxilaprevir
Please note: medicines on the above list are not the only medicines which interact with colchicine in this way, so ask your doctor or pharmacist for a medicine interactions check.
Colchicine also has other types of interactions. Here are some examples of other interactions with colchicine (from Colgout brand colchicine product information for doctors):
*Alcohol increases risk of colchicine toxicity side effects like nausea, vomiting, diarrhoea, stomach or intestine pain, and increases gout flare risk by raising uric acid level
*Colchicine may increase risk of potential muscle side effects (like muscle tenderness or weakness) of some statin or fibrate medicines for cholesterol (e.g. simvastatin, atorvastatin, lovastatin, gemfibrozil, fenofibrate)
*Colchicine may increase risk of low blood cell production if taken with other medicines with this potential side effect
*Acidifying substances (like ammonium chloride, ascorbic acid (vitamin C), acid phosphates) may make colchicine less effective
*Alkalinizing substances (like sodium bicarbonate, potassium citrate) may increase the effect of colchicine
*Colchicine may increase the effect of medicines that make us sleepy, and alcohol
*Colchicine may increase the effect of adrenaline, dopamine, dobutamine, isoprenaline or ephedrine
*If colchicine is taken long-term, it may decrease absorption of vitamin B12, so ask your doctor for a blood test for vitamin B12 - to find out if you may need a vitamin B12 supplement
*The herbal medicine St John's Wort (Hypericum perforatum) may make colchicine less effective, by making our body get rid of colchicine quicker than usual; some types of medicines may interact with colchicine in this way
If you think you might have one of these interactions, ask a doctor for advice as soon as possible about whether any medicine changes may or may not be needed.
Please note: these are not all of the possible colchicine interactions, so ask a doctor or pharmacist for a medicine interactions check.
INFO FOR DOCTORS
Here is a link to Colcrys Prescribing Information on FDA website (revised 2020) with a modern colchicine dose schedule for treatment of acute gout flare for people with good kidney and liver function ('Treatment of Gout Flares', at base of page 3), plus schedules for people with kidney or liver impairment ('Treatment of Gout Flares' on pages 8 & 9, respectively): https://www.accessdata.fda.gov..../drugsatfda_docs/lab
We hope this video has been helpful for you.
Please also see disclaimer at the end of the video.