- Ozempic
- Mounjaro
- Wegovy
- Semaglutide
- Retinol
- Finasteride
- Metformin
- Wellbutrin
- Melatonin
- Ashwagandha
- Lexapro
- Sertraline
- Creatine
- Prozac
- Fluoxetine
- Pregabalin
- Spironolactone
- Amlodipine
- Trazodone
- Akathisia
- Steroids
- Prednisone
- Doxycycline
- Tramadol
- Lisinopril
- Losartan
- Amoxicillin
- Androgenic
- Azithromycin
- Zoloft
- Statin
- Atorvastatin
- Acetylcysteine
- Adderall
- Alprazolam
- Amitriptyline
- Augmentin
- Cetirizine
- Cipro
- Clonazepam
- Clotrimazole
- Diazepam
- Fentanyl
- Gabapentin
- Hydroxyzine
- Ibuprofen
- Ivermectin
- Lorazepam
- Magnesium
- Meloxicam
- Metoprolol
- Metronidazole
- Mirtazapine
- Naproxen
- Omega 3
- Omeprazole
- Ondansetron
- Paracetamol
- Propranolol
- Quetiapine
- Sildenafil
- Tamsulosin
- Tirzepatide
- Tylenol
- Viagra
- Vitamin B12
- Vitamin C
- Vitamin D
- Xanax
- Acetaminophen
- Acyclovir
- Advil
- Albendazole
- Albuterol
- Alendronate
- Alfuzosin
- Allopurinol
- Amantadine
- Ambien
- Ambroxol
- Amiodarone
- Ampicillin
- Anastrozole
- Apixaban
- Aripiprazole
- Ascorbic Acid
- Aspirin
- Atarax
- Atenolol
- Ativan
- Atomoxetine
- Azelastine
- Bacitracin
- Baclofen
- Bactrim
- Bactroban
- Benadryl
- Bentyl
- Benzonatate
- Benztropine
- Betadine
- Betamethasone
- Biktarvy
- Biotin
- Bisacodyl
- Bisoprolol
- Botox
- Brilinta
- Budesonide
- Glycopyrrolate
- Bumetanide
- Buprenorphine
- Bupropion
- Buspar
- Buspirone
- Calcitriol
- Candesartan
- Captopril
- Carbamazepine
- Carvedilol
- Cefdinir
- Cefixime
- Ceftriaxone
- Cefuroxime
- Celebrex
- Celexa
- Cephalexin
- Chlorpheniramine
- Chlorthalidone
- Cholecalciferol
- Cialis
- Cilostazol
- Citalopram
- Claritin
- Clindamycin
- Clobetasol
- Clonidine
- Clopidogrel
- Clozapine
- Codeine
- Colace
- Colchicine
- Concerta
- Cosentyx
- Crestor
- Cyanocobalamin
- Cyclobenzaprine
- Cymbalta
- Dabigatran
- Dapagliflozin
- Decadron
- Denosumab
- Depakote
- Desloratadine
- Desvenlafaxine
- Dexamethasone
- Dexilant
- Dextroamphetamine
- Dextromethorphan
- Dextrose
- Dicyclomine
- Diflucan
- Digoxin
- Dilaudid
- Diltiazem
- Diphenhydramine
- Divalproex
- Docusate Sodium
- Domperidone
- Donepezil
- Dopamine
- Doxazosin
- Doxepin
- Doxycycline Hyclate
- Doxylamine
- Dulcolax
- Duloxetine
- Dupixent
- Dutasteride
- Echinacea
- Effexor
- Eliquis
- Empagliflozin
- Enalapril
- Epinephrine
- Epipen
- Erythromycin
- Escitalopram
- Esomeprazole
- Estradiol
- Euthyrox
- Excedrin
- Ezetimibe
- Famotidine
- Farxiga
- Febuxostat
- Fenofibrate
- Ferrous Sulfate
- Fexofenadine
- Fish Oil
- Flagyl
- Flecainide
- Flexeril
- Flomax
- Flonase
- Fluticasone
- Fluvoxamine
- Folic Acid
- Formoterol
- Fosamax
- Fosfomycin
- Furosemide
- Gardasil 9
- Garlic
- Gas X
- Gaviscon
- Gentamicin
- Ginkgo Biloba
- Ginseng
- Glimepiride
- Glipizide
- Glucagon
- Glucophage
- Glucosamine
- Glutathione
- Glycerin
- Griseofulvin
- Guaifenesin
- Guanfacine
- Haldol
- Haloperidol
- Heparin
- Hibiclens
- Humira
- Hydralazine
- Hydrea
- Hydrochlorothiazide
- Hydrocodone
- Hydrocortisone
- Hydromorphone
- Hydroxyurea
- Hyoscyamine
- Imiquimod
- Imodium
- Indapamide
- Inderal
- Indomethacin
- Infliximab
- Irbesartan
- Isosorbide
- Isosorbide Mononitrate
- Isotretinoin
- Itraconazole
- Ivabradine
- Janumet
- Januvia
- Japanese Knotweed
- Jardiance
- Kava
- Keflex
- Kenalog
- Keppra
- Ketoconazole
- Ketoconazole Shampoo
- Ketoprofen
- Ketorolac
- Keytruda
- Klonopin
- Labetalol
- Lacosamide
- Lactulose
- Lamictal
- Lamotrigine
- Lansoprazole
- Lantus
- Lasix
- Latanoprost
- Latuda
- Leflunomide
- Letrozole
- Levetiracetam
- Levocetirizine
- Levofloxacin
- Levothyroxine
- Lidocaine
- Linezolid
- Linzess
- Lipitor
- Liraglutide
- Lisdexamfetamine
- Lithium
- Lokelma
- Lomotil
- Loperamide
- Loratadine
- Lovenox
- Lyrica
- Macrobid
- Magnesium Citrate
- Magnesium Oxide
- Meclizine
- Medrol
- Mefenamic Acid
- Memantine
- Meropenem
- Metamucil
- Methadone
- Methimazole
- Methocarbamol
- Methotrexate
- Methylphenidate
- Methylprednisolone
- Metoclopramide
- Metoprolol Succinate
- Midazolam
- Midodrine
- Mirabegron
- Miralax
- Mobic
- Modafinil
- Montelukast
- Morphine
- Motrin
- Moxifloxacin
- Mucinex
- Mupirocin
- Nac
- Naloxone
- Naltrexone
- Narcan
- Nebivolol
- Neomycin
- Neosporin
- Neurontin
- Nexium
- Nexplanon
- Niacin
- Nifedipine
- Nitrofurantoin
- Nitroglycerin
- Norco
- Norepinephrine
- Norethindrone
- Nortriptyline
- Norvasc
- Octreotide
- Ofloxacin
- Olanzapine
- Olmesartan
- Orlistat
- Oseltamivir
- Oxazepam
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Oxycontin
- Oxygen
- Paroxetine
- Paxil
- Paxlovid
- Pepcid
- Percocet
- Phenazopyridine
- Phenergan
- Phenobarbital
- Phentermine
- Phenylephrine
- Phenytoin
- Pioglitazone
- Plan B
- Plaquenil
- Plavix
- Potassium Chloride
- Pradaxa
- Pravastatin
- Prazosin
- Prednisolone
- Prilosec
- Pristiq
- Prochlorperazine
- Progesterone
- Prolia
- Promethazine
- Propofol
- Protonix
- Pseudoephedrine
- Psyllium
- Pyridium
- Quercetin
- Quinine
- Rabeprazole
- Ramipril
- Ranitidine
- Ranolazine
- Reglan
- Remeron
- Repatha
- Rexulti
- Rifaximin
- Rinvoq
- Risperdal
- Risperidone
- Ritalin
- Rituximab
- Rivaroxaban
- Rizatriptan
- Robaxin
- Rocephin
- Rosuvastatin
- Rybelsus
- Salbutamol
- Scopolamine
- Senna
- Senokot
- Seroquel
- Simvastatin
- Singulair
- Sitagliptin
- Skyrizi
- Sodium Bicarbonate
- Sodium Chloride
- Solifenacin
- Soma
- Sotalol
- Spiriva
- Strattera
- Suboxone
- Sucralfate
- Sudafed
- Sulfasalazine
- Sumatriptan
- Symbicort
- Synthroid
- Tacrolimus
- Tadalafil
- Tamiflu
- Tamoxifen
- Tegretol
- Telmisartan
- Temazepam
- Tetracycline
- Thiamine
- Ticagrelor
- Tizanidine
- Topamax
- Topiramate
- Toradol
- Torsemide
- Tranexamic Acid
- Tremfya
- Tresiba
- Tretinoin
- Triamcinolone
- Triamcinolone Acetonide
- Trileptal
- Trimethoprim
- Trintellix
- Trulicity
- Ubrelvy
- Ultracet
- Unisom
- Urea
- Urea Cream
- Urso
- Ursodiol
- Valacyclovir
- Valium
- Valsartan
- Valtrex
- Vancomycin
- Varenicline
- Venlafaxine
- Ventolin
- Veozah
- Verapamil
- Vicodin
- Victoza
- Vistaril
- Vitamin B6
- Vitamin D3
- Vitamin E
- Vraylar
- Vyvanse
- Warfarin
- Witch Hazel
- Wormwood
- Xarelto
- Xenical
- Xifaxan
- Xolair
- Xylitol
- Xyzal
- Yarrow
- Yasmin
- Yaz
- Yellow Fever Vaccine
- Zantac
- Zepbound
- Zetia
- Zinc
- Zithromax
- Zofran
- Zoladex
- Zolpidem
- Zopiclone
- Zovirax
- Zyprexa
- Zyrtec
- Hydroxytryptophan
- Serious
- Other
![5-Hydroxytryptophan Side Effects & Benefits | Joy Lab Podcast [ep. 147]](https://i.ytimg.com/vi/nA7pWhv9QLI/maxresdefault.jpg)
Podcast 585: You Sure You Want Colchicine for Gout?
Contributor: Don Stader, MD
Educational Pearls:
1. Gout is an arthritis caused by the deposition of urate crystals into the joint space
2. Colchicine works by disrupting microtubules and prevents white blood cells from getting into the joint space which stops the inflammatory response
3. Colchicine has a high rate of adverse events, in particular explosive diarrhea
4. The drug also has a very narrow therapeutic index and overdose is nearly universally fatal, with no antidote or effective treatment option available
5. Alternative agents such as steroids, which reduce the inflammatory response to urate crystals, along with NSAIDs may be better options for treatment
References
Angelidis C, Kotsialou Z, Kossyvakis C, et al. Colchicine Pharmacokinetics and Mechanism of Action. Curr Pharm Des. 2018;24(6):659-663. doi:10.2174/1381612824666180123110042
Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48(5):407-414. doi:10.3109/15563650.2010.495348
Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388(10055):2039-2052. doi:10.1016/S0140-6736(16)00346-9
Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD
The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cme-courses/ and create an account.
Donate to EMM today: https://www.paypal.com/donate/....?token=CWfNGAw4j2pU0
Episode Link on Website: https://emergencymedicalminute.....org/podcast-585-you
SORT BY-
Top Comments
-
Latest comments