Webinar on Mexiletine : An Unexplored Antiarrhythmic Drug by Dr. Rajeev Marwaha, MD Cardio, Associate Professor, IGMC Shimla

Efficacy and Safety of Sotalol in Patients with Left Ventricular Hypertrophy

Webinar on Mexiletine : An Unexplored Antiarrhythmic Drug by Dr. Hiren Kevadiya Patel who is an Interventional Cardiac Electrophysiologist at CIMS Hospital, Ahmedabad, Gujarat

Class II drugs - beta blockers - indications, side effects
Class III drugs - K channel blockers - Pk, uses, ADRs, CIs

Sotalol is a unique medication that combines two powerful actions: it's both a non-selective beta-blocker and a Class III antiarrhythmic agent. That means it slows the heart rate and helps stabilize abnormal heart rhythms—especially in conditions like atrial fibrillation, atrial flutter, and ventricular tachycardia2.

💊 Pharmacology Snapshot
Feature Details
Drug Class Beta-blocker + Class III antiarrhythmic
Mechanism Blocks β1 & β2 receptors; prolongs cardiac repolarization by inhibiting potassium channels
Bioavailability ~90–100% orally
Half-life ~12 hours
Excretion Primarily via kidneys
🩺 Clinical Uses
Maintains normal rhythm in atrial fibrillation/flutter

Treats life-threatening ventricular arrhythmias

Sometimes used off-label for essential tremor or migraine prevention

It’s typically reserved for patients with symptomatic or high-risk arrhythmias, due to its potential for serious side effects2.

⚠️ Side Effects & Risks
Common Serious
Fatigue, dizziness, nausea QT prolongation, torsades de pointes, bradycardia, heart failure2
QT prolongation is a major concern—it can lead to dangerous arrhythmias like torsades de pointes

Requires hospital monitoring for at least 3 days when starting or restarting therapy

🚫 Contraindications
Asthma or COPD

Severe heart failure

Long QT syndrome

Bradycardia or AV block (unless pacemaker is present)

Low potassium or magnesium levels

Severe kidney disease

🧪 Monitoring & Administration
Initiated in a hospital setting with ECG monitoring

Dosage adjusted based on renal function and QT interval

Available as oral tablets, oral solution, and IV infusion
#Sotalol

SESSION 4 ▪ Rhythm
Anti-Arrhythmics 101 (Wilson Lam, MD)

CARDIAC SURGERY TRACK
CARDIOVASCULAR FELLOWS’ BOOT CAMP 2017
Hosted by the DeBakey Institute for Cardiovascular Education & Training
"Laying the Foundation" AUGUST 3-5, 2017

Beta blockers are a class of medications that are used to treat a variety of conditions, including high blood pressure, angina (chest pain), heart failure, and abnormal heart rhythms (arrhythmias). They work by blocking the effects of adrenaline, a hormone that can raise your heart rate and blood pressure.

What are beta blockers?
How do beta blockers work?
What are the uses of beta blockers?
What are the side effects of beta blockers?
What are the different types of beta blockers?
How to choose the right beta blocker for you
This video is a great resource for anyone who wants to learn more about beta blockers. We will provide you with a comprehensive overview of this important class of medications.
Beta blockers
High blood pressure
Angina
Heart failure
Arrhythmias
Adrenaline
Side effects
Types of beta blockers
How to choose the right beta blocker



SANTINIKETAN MEDICAL COLLEGE & HOSPITAL
Real Classroom Demonstration/Lecture
On: PHARMACOLOGY by Siddhartha Ghosh
(MBBS Batch: 2023-24)
Conducted on: 08-11-2024

Classes of antiarrhythmics:

Class I (Sodium blockers): Quinidine, lidocaine; for atrial/ventricular arrhythmias; risk: cinchonism.
Class II (Beta-blockers): Metoprolol; for SVT, AF rate control; risk: COPD exacerbation, AV block.
Class III (Potassium blockers): Amiodarone, sotalol; for VT; risks: pulmonary fibrosis, Torsades.
Class IV (Calcium blockers): Verapamil; for AF rate control; risk: edema, constipation, AV block.
Others: Adenosine for SVT; risk: hypotension, flushing, bronchospasm.

Webinar on Mexiletine : An Unexplored Antiarrhythmic Drug by Dr. Mehraj Ud Din Shah, Senior Consultant Cardiologist, Al-Kareem Medical Centre, Srinagar, New Kashmir.

Webinar by Dr. Johann Christopher, Consultant Cardiologist, Care Super speciality Hospital, Hyderabad, Telangana.

💓 Understanding antidysrhythmic medications is essential for safe and effective cardiac care! 💓

In this video, we’ll break down the key antidysrhythmic (antiarrhythmic) drugs that every nursing student needs to know, including:
✅ The main classes of antidysrhythmic medications
✅ How they work (mechanism of action)
✅ Common side effects & nursing considerations
✅ NCLEX tips & must-know facts for exams
✅ Real-world applications in clinical practice

Medications covered include:
🩺 Class I (Sodium Channel Blockers) – Lidocaine, Procainamide
🩺 Class II (Beta-Blockers) – Metoprolol, Propranolol
🩺 Class III (Potassium Channel Blockers) – Amiodarone, Sotalol
🩺 Class IV (Calcium Channel Blockers) – Diltiazem, Verapamil
🩺 Other important drugs – Adenosine, Digoxin

From bradycardia to ventricular tachycardia, knowing how these drugs work is critical for patient safety! Let’s simplify pharmacology and make antidysrhythmic meds easy to remember.

📚 Want more pharmacology help? Check out our other nursing videos!
💬 Comment below with your questions or mnemonics for memorizing these meds!
👍 Like & Subscribe for more nursing education & NCLEX prep!

#NursingPharmacology #Antidysrhythmics #NCLEX #NursingStudents #Pharmacology #CardiacMeds #NursingSchool #pharmacologyfornurses

1 uses of sotalol tablet
Used in the treatment of arrhythmia and tachycardia.

2 side effects of sotalol tablet
Fatigue
Breathlessness
Dizzines
Chest pain

4 severe interactions of sotalol tablet with other drugs.
Alfuzosin
Caffeine
Amlodipine


How to use sotalol tablet
Take this medicine in the dose and duration as advised by your doctor. Sotalol 40mg tablet may be taken with or without food, but it is better to take it at a fixed time.

Sotalol is a non-selective beta-adrenergic receptor blocker with class III antiarrhythmic properties. It is widely used for the management of various cardiac arrhythmias due to its unique combination of beta-blocking and potassium channel-blocking effects. Below is a detailed breakdown of its pharmacology:

Mechanism of Action
Beta-Adrenergic Receptor Blockade (Class II)

Sotalol non-selectively blocks beta-1 and beta-2 adrenergic receptors, leading to:

Decreased heart rate (negative chronotropy).

Reduced myocardial contractility (negative inotropy).

Prolongation of atrioventricular (AV) nodal conduction time, which helps control heart rate during arrhythmias.

Potassium Channel Blockade (Class III)

Sotalol blocks delayed rectifier potassium channels (IKr), which prolongs the action potential duration and the effective refractory period in cardiac myocytes.

This effect reduces the risk of reentrant arrhythmias and stabilizes cardiac rhythms.

Pharmacokinetics
Administration:

Administered orally or intravenously.

Absorption:

Well-absorbed after oral administration, with a bioavailability of approximately 90–100%.

Distribution:

Does not bind significantly to plasma proteins, and its volume of distribution is relatively small.

Metabolism:

Sotalol is not significantly metabolized; most of the drug remains unchanged.

Excretion:

Primarily excreted unchanged via the kidneys. Renal function plays a critical role in its clearance.

Half-Life:

The elimination half-life is approximately 10–20 hours, depending on renal function.

Indications
Supraventricular Arrhythmias:

Used for conditions such as atrial fibrillation (AF) or atrial flutter.

Ventricular Arrhythmias:

Effective in treating life-threatening ventricular tachycardia or preventing ventricular fibrillation.

Maintenance of Sinus Rhythm:

Helps in maintaining sinus rhythm after cardioversion in patients with AF.

Adverse Effects
Cardiac Effects:

Prolongation of the QT interval, which increases the risk of torsades de pointes (a life-threatening ventricular arrhythmia).

Bradycardia and AV block.

Negative inotropic effects can precipitate heart failure in susceptible patients.

Non-Cardiac Effects:

Fatigue and dizziness.

Shortness of breath (due to beta-2 blockade causing bronchospasm, particularly in asthmatic patients).

Gastrointestinal discomfort (e.g., nausea, vomiting).

Electrolyte Abnormalities:

Hypokalemia and hypomagnesemia can exacerbate QT prolongation and arrhythmic risk.

#Sotalol

📹 Sotalol 80 mg (Betapace): Uses, Dosage, Side Effects & Warnings – Complete Guide

Looking to learn more about Sotalol 80 mg (Betapace) and how it helps manage irregular heartbeats? This video breaks down everything you need to know about this important medication for heart rhythm conditions.

🔍 What You’ll Discover in This Video:
✔️ Uses: How Sotalol treats serious arrhythmias (irregular heartbeats) and helps prevent life-threatening conditions like ventricular tachycardia.
✔️ Dosage: Proper dosing for adults, how often to take it, and why it's essential to follow your doctor’s instructions carefully.
✔️ Side Effects: Common side effects like dizziness and fatigue, plus serious risks like bradycardia (slow heartbeat) or chest pain.
✔️ Warnings: Critical precautions for people with heart, kidney, or breathing problems. Understand why regular heart monitoring is vital during treatment.

Sotalol belongs to a class of medications called beta-blockers and antiarrhythmics. It works by regulating the heart’s electrical activity to maintain a steady heartbeat. This video provides simple, clear explanations to help you use this medication safely and effectively.

💊 Who Should Watch?
Patients diagnosed with arrhythmia or other irregular heart rhythms.
People prescribed Sotalol (Betapace) seeking more information about their medication.
Caregivers supporting loved ones on Sotalol.
🔔 Don’t forget to LIKE, SUBSCRIBE, and hit the NOTIFICATION BELL for more medical and pharmaceutical insights. Leave your questions in the comments, and we’ll be happy to help!

👉 Disclaimer: This video is for educational purposes only. Always consult with your doctor or healthcare provider before starting or changing any medications.

#Sotalol #Betapace #ArrhythmiaTreatment #HeartHealth #PharmaceuticalVideos #MedicalEducation #IrregularHeartbeat #HealthTips

Sotalol Demystified: Exploring Its Benefits and Risks

Let's demystify sotalol and uncover its remarkable benefits and associated risks. This video provides a comprehensive overview of sotalol's mechanism of action, indications, common side effects, and potential complications. Stay informed and join our community by subscribing to our channel!

WE DO NOT BUY OR SELL MEDICINE IN ANY WAY, AND WE NEVER ENCOURAGE THE USE OF MEDICINES WITHOUT REFERRING TO A DOCTOR. We explain some information about medicines and give simplification and only! We repeat NEVER use the drug without consulting a DOCTOR.

The channel is hosted by a team of qualified medical professionals who are passionate about educating the public on the benefits and potential risks of medicines. Each video is carefully crafted to provide in-depth, yet easy-to-understand explanations of different medications, how they work, and what they are used for.

Whether you're a patient looking to better understand your medication, a healthcare professional seeking to deepen your knowledge, or just someone with a general interest in medicine, this channel has something for you. The videos cover a wide range of topics, from over-the-counter remedies to prescription drugs used to treat chronic illnesses.

WE NEVER ENCOURAGE THE USE OF MEDICINES WITHOUT REFERRING TO A DOCTOR

Cardiovascular Fellows' Bootcamp 2016

RHYTHM SESSION

"Anti-Arrhythmics 101"
Wilson Lam, MD

Sunday, August 21, 2016

[email protected]

Cardiovascular disease remains the number one killer in this country, and one of the most commonly seen cardio conditions is AFib. An irregular heartbeat, it leads to a higher risk of stroke.

“The risks are completely different depending upon a variety of issues including the history of prior stroke, heart failure, high blood pressure, diabetes, vascular disease, age, and gender,” says Lee Memorial Health System cardiologist Dr. Richard Chazal.
With the help of a risk calculator, doctors assess each patient. Much research and development is being aimed towards AFib, but the simple truth is, that one of the most basic, time-tested treatments remains the best first line approach.
“In 2014, the American College of Cardiology and the American Heart Association released guidelines on treatment of patients with atrial fibrillation. In most cases, patients with minimal symptoms are recommended to be treated with control of the heart rate and also anticoagulant blood thinners to reduce the likelihood of having a stroke,” says Dr. Chazal.
At the same time advances are being made in surgical treatments for AFib, R&D is put to use in developing new drugs. These medications are easier to take than in years past. The hope is more people who need them will find drug therapy easier to swallow.

“Their advantage is a reduction in the likelihood of interaction with other medications, a reduction in the likelihood of interaction with certain foods or beverages that could be problematic with warfarin or Coumadin, and importantly, the lack of need for regular blood test to monitor the control of the anticoagulant,” says Dr. Chazal.
A risky condition, your doctors can recommend the right line of treatment for AFib that will reduce the stress on your health.

View More Health Matters video segments at leememorial.org/healthmatters/

Lee Memorial Health System in Fort Myers, FL is the largest network of medical care facilities in Southwest Florida and is highly respected for its expertise, innovation and quality of care. For nearly a century, we’ve been providing our community with everything from primary care treatment to highly specialized care services and robotic assisted surgeries.

Visit leememorial.org

Class III antiarrhythmics are a group of medications used to manage and treat certain types of cardiac arrhythmias, which are abnormal heart rhythms. These drugs primarily target the electrical properties of the heart to restore normal rhythm and prevent further arrhythmias. Unlike some other classes of antiarrhythmic drugs, class III antiarrhythmics do not predominantly affect the speed of electrical impulses in the heart but primarily affect the duration of action potentials.

One of the most well-known and commonly used class III antiarrhythmics is amiodarone. Other drugs in this class include dofetilide, sotalol, and ibutilide.

Here are some key points about class III antiarrhythmics:

1. Mechanism of Action: Class III antiarrhythmics primarily work by prolonging the action potential duration in cardiac cells, particularly in the atria and ventricles. This prolongation helps prevent the reentry of electrical impulses that can lead to certain types of arrhythmias, such as atrial fibrillation or ventricular tachycardia.

2. Indications: These drugs are used to treat a range of cardiac arrhythmias, including atrial fibrillation, atrial flutter, ventricular tachycardia, and some forms of ventricular fibrillation. They may also be used for patients who have had certain types of cardiac surgery to prevent arrhythmias.

3. Amiodarone: Amiodarone is one of the most commonly prescribed class III antiarrhythmics. It is effective in treating various types of arrhythmias but is known for its potential for serious side effects and long-term use monitoring. It can affect multiple organ systems, including the lungs, thyroid, liver, and eyes.

4. Dofetilide: Dofetilide is primarily used for treating atrial fibrillation and atrial flutter. It requires careful dosing adjustments and monitoring of kidney function because it is eliminated by the kidneys.

5. Sotalol: Sotalol has both beta-blocking and class III antiarrhythmic properties. It is used to treat ventricular arrhythmias and atrial fibrillation. Like dofetilide, it requires careful dosing and monitoring.

6. Ibutilide: Ibutilide is often used for short-term treatment of atrial fibrillation or atrial flutter. It is typically administered in a hospital setting due to its potential to cause serious arrhythmias as a side effect.

7. Side Effects: Class III antiarrhythmics can have significant side effects, including proarrhythmia (the development of new or worsened arrhythmias), bradycardia (slow heart rate), and other cardiac and non-cardiac adverse effects. Regular monitoring of patients taking these medications is essential.

8. Individualized Treatment: The choice of which class III antiarrhythmic drug to use depends on the specific type of arrhythmia, the patient's overall health, and other factors. These medications are often prescribed after careful evaluation by a cardiologist.

It's important to note that the use of class III antiarrhythmics requires close monitoring by a healthcare professional due to their potential for serious side effects and interactions with other medications. Patients should always follow their healthcare provider's instructions when taking these drugs and report any unusual symptoms or side effects promptly.

Sotalol side effects 💊 - what is sotalol used for

General information regarding Sotalol. Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

What is Sotalol and how does it work?
Sotalol is a medication classified as a beta-blocker and antiarrhythmic agent. It works by blocking certain receptors in the heart, which reduces the heart's response to adrenaline and other stress hormones. By doing so, Sotalol helps regulate the heart's rhythm and prevents the occurrence of irregular heartbeats.
Sotalol has both beta-blocking and potassium channel-blocking properties. The beta-blocking effect helps slow down the heart rate, while the potassium channel-blocking effect prolongs the repolarization phase of the cardiac cycle. This combined action helps restore and maintain a normal heart rhythm, making Sotalol an effective treatment option for various types of arrhythmia.
Efficacy of Sotalol in treating arrhythmia
Numerous studies have investigated the efficacy of Sotalol in managing arrhythmia, and the results have been promising. In a randomized controlled trial involving patients with atrial fibrillation, Sotalol was found to be significantly more effective than a placebo in maintaining normal sinus rhythm. Another study comparing Sotalol to other antiarrhythmic drugs showed that Sotalol was as effective, if not more, in preventing recurrent ventricular arrhythmias.
Sotalol has also demonstrated its efficacy in preventing sudden cardiac death in patients with a history of life-threatening ventricular arrhythmias. In a large-scale clinical trial, Sotalol was compared to a placebo in patients who had survived a previous cardiac arrest or had sustained ventricular tachycardia. The study found that Sotalol significantly reduced the risk of recurrent ventricular arrhythmias and improved overall survival rates.
Potential side effects of Sotalol
Like any medication, Sotalol comes with potential side effects that should be considered before starting treatment. The most common side effects of Sotalol include fatigue, dizziness, and shortness of breath. These symptoms are usually mild and transient, but if they persist or worsen, it is important to consult a healthcare professional.
Sotalol can also cause more serious side effects, although they are less common. One such side effect is a prolonged QT interval, which can increase the risk of a life-threatening arrhythmia called Torsades de Pointes. This risk is higher in patients with pre-existing heart conditions, electrolyte imbalances, or those taking other medications that can prolong the QT interval. Regular monitoring of the QT interval is crucial for patients on Sotalol to ensure safety and optimize treatment outcomes.
Factors to consider before starting Sotalol treatment
Before starting Sotalol treatment, several factors should be considered to ensure its suitability and safety for each individual patient. These factors include the patient's medical history, current medications, and any known allergies. Sotalol may interact with certain medications, such as other beta-blockers or medications that prolong the QT interval, so it is essential to inform the healthcare provider about all medications being taken.
Patients with underlying heart conditions, liver or kidney problems, or a history of asthma or other respiratory disorders may require closer monitoring while on Sotalol. Additionally, pregnant or breastfeeding individuals should discuss the potential risks and benefits of Sotalol with their healthcare provider before initiating treatment.
Sotalol dosage and administration guidelines
The dosage of Sotalol can vary depending on the specific arrhythmia being treated and individual patient characteristics. It is typically initiated at a low dose and gradually increased under medical supervision to achieve the desired therapeutic effect. The healthcare provider will determine the appropriate dosage based on factors such as the patient's age, renal function, and overall health.

"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

A drug recommended to use to treat and prevent only life-threatening ventricular arrhythmias due to potentially serious side effects (generally not recommended for less severe arrhythmias). It is taken by mouth or intravenously.

It is a non-selective beta-adrenergic receptor blocker with class II (beta-blocker) and III (potassium channel blocker) antiarrhythmic properties. It is a "pure" potassium channel blockers which produces little or no other cardiac ion channel electrophysiologic effect, as well as dofetilide and possibly ibutilide.

It can cause life-threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug-induced arrhythmia, give it by oral administration in a facility that can provide cardiac resuscitation and continuous electrocardiographic monitoring.
Do not use it if baseline corrected QT is 450 msec or greater. If the QT interval prolongs to 500 msec or greater, reduce the dose, lengthen the dosing interval, or discontinue the drug.

It is nearly completely absorbed after oral administration and undergoes essentially no first-pass hepatic metabolism, resulting in its absolute bioavailability at 90-100%.
It is primarily eliminated by renal excretion, with approximately 80-90% of a dose being excreted unchanged in the urine, and a small amount is excreted unchanged in the feces.
Calculate creatinine clearance to determine appropriate dosing.

(Common side effects)
• bradycardia
• hypotension
• chest pain
• shortness of breath
• dizziness
• weakness
• blurred vision
• nausea, vomiting
• edema

(Serious side effects)
• QT prolongation
• heart failure
• bronchospasm

Welcome to MediInsights, where we unlock the wonders of wellness. In this video, we delve into everything you need to know about Sotalol Tablets, a critical medication used to treat certain types of irregular heartbeats, such as atrial fibrillation and ventricular arrhythmias.

Key Highlights:

Use of Sotalol Tablets: Discover how Sotalol helps maintain a regular heart rhythm, preventing severe and potentially life-threatening arrhythmias.

Dosage of Sotalol Tablets: We explain the importance of proper dosage, starting with 80 mg twice daily and adjusting as needed under medical supervision to achieve the best results while minimizing risks.

Mechanism of Action of Sotalol Tablets: Learn how Sotalol works as a non-selective beta-blocker and antiarrhythmic agent, blocking beta-adrenergic receptors and potassium channels to slow the heart rate and stabilize electrical activity.

Side Effects of Sotalol Tablets: Understand the common and serious side effects of Sotalol, including fatigue, dizziness, shortness of breath, and the potential for severe bradycardia and QT prolongation.

Important Advice of Sotalol Tablets: We share crucial tips for safely using Sotalol, including the need for regular monitoring, the dangers of abrupt discontinuation, and the importance of dose adjustments for patients with kidney issues.

Whether you or a loved one are prescribed Sotalol or you’re a healthcare professional seeking to expand your knowledge, this video provides a comprehensive overview. Don’t forget to like, share, and subscribe to MediInsights for more expert advice and insights into the world of health and wellness.

#SotalolTablets #HeartHealth #ArrhythmiaTreatment #MediInsights #Wellness #Health #MedicalEducation #Cardiology
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#MedicationGuide
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#Health
#HeartRhythm
#PatientCare
#Pharmacology
#WellnessJourney
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Disclaimer: This video is intended for educational and informational purposes only. The content provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or the use of medications. The information presented here is based on general knowledge and research and may not be applicable to individual circumstances. The creators of this video do not endorse or promote any specific medical products or treatment regimens. Viewers are encouraged to consult their healthcare provider for personalized medical advice. The content provided in this video complies with YouTube's community guidelines and policies.

0:00 :INTRO
0:28 :USE OF SOTALOL TABLETS
0:45 :DOSAGE OF SOTALOL TABLETS
1:09 :MECHANISM OF ACTION OF SOTALOL TABLETS
1:29 :SIDE EFFECTS OF SOTALOL TABLETS
1:47 :IMPORTANT ADVICES FOR USING SOTALOL TABLETS

Discover how Sotalol works as a dual-acting medication for heart rhythm problems with beta-blocker and cardiac action potential duration prolongation effects. Learn about Sotalol's side effects, like QT interval prolongation leading to ventricular tachycardia. Plus, tips on managing risks with regular kidney function tests, ECGs, and electrolyte monitoring. Stay informed about your heart health with Sotalol insights.