sotalol

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Side Effects

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A drug recommended to use to treat and prevent only life-threatening ventricular arrhythmias due to potentially serious side effects (generally not recommended for less severe arrhythmias). It is taken by mouth or intravenously.

It is a non-selective beta-adrenergic receptor blocker with class II (beta-blocker) and III (potassium channel blocker) antiarrhythmic properties. It is a "pure" potassium channel blockers which produces little or no other cardiac ion channel electrophysiologic effect, as well as dofetilide and possibly ibutilide.

It can cause life-threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug-induced arrhythmia, give it by oral administration in a facility that can provide cardiac resuscitation and continuous electrocardiographic monitoring.
Do not use it if baseline corrected QT is 450 msec or greater. If the QT interval prolongs to 500 msec or greater, reduce the dose, lengthen the dosing interval, or discontinue the drug.

It is nearly completely absorbed after oral administration and undergoes essentially no first-pass hepatic metabolism, resulting in its absolute bioavailability at 90-100%.
It is primarily eliminated by renal excretion, with approximately 80-90% of a dose being excreted unchanged in the urine, and a small amount is excreted unchanged in the feces.
Calculate creatinine clearance to determine appropriate dosing.

(Common side effects)
• bradycardia
• hypotension
• chest pain
• shortness of breath
• dizziness
• weakness
• blurred vision
• nausea, vomiting
• edema

(Serious side effects)
• QT prolongation
• heart failure
• bronchospasm

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