Eszopiclone is an S-isomer of Zopiclone which is a non-benzodiazepine hypnotic agent. This drug structurally different from benzos but still acts like them. Chemically this drug belongs to cyclopyrrolones with pyrrolopiperazine ring system.

Your medication Eszopiclone

Eszopiclone is also known by the brand name: Lunesta.
Eszopiclone comes in 1, 2, and 3mg tablets.
Eszopiclone is most commonly used for treating sleep problems. This medication is taken by mouth right before you get into bed. Do not take with or right after a meal.
Standard dosing of eszopiclone ranges from 1mg to 3mg once nightly at bedtime.
The best way to store eszopiclone:
• Store at room temperature.
• Store in a dry place. Do not store in a bathroom or refrigerator.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

Some common side effects with eszopiclone include headache and a foul, salty, or metallic taste sensation that will persist in the mouth.
Some less common side effects include chest pain, drowsiness, dizziness, confusion, abnormal dreams, anxiety, and migraines.
Do not take eszopiclone if you have hypersensitivity to eszopiclone or any component of the formulation.
If you miss a dose of eszopiclone:
• This medication is taken on an as needed basis. Do not take more often than every 24 hours, unless told to do so by your doctor

When taking eszopiclone, remember it is important to tell your doctor or pharmacist if:
• You have signs of an allergic reaction, like rash; hives; itching; blistered, or peeling skin with or without fever
• You have signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life
• You have hallucinations (seeing or hearing things that are not there)
• You have memory problems or loss
• You have very bad dizziness
• You have a change in balance
• You are feeling confused
• You are feeling very tired or weak
• You have a very upset stomach or are throwing up

In this webinar, Lais Berro, PhD presents recent research demonstrating the anxiolytic, sedative and abuse-related effects of benzodiazepine drugs, and how they correlate with telemetry-based EEG recordings in a translational non-human primate model.


Benzodiazepines are known to induce electroencephalography (EEG) changes in rodents and humans that are associated with distinct behavioral effects and have been proposed as quantitative biomarkers for GABAA receptor modulation. Specifically, central EEG beta and occipital EEG delta activity have been associated with anxiolysis and sedation, respectively. The extent to which nonhuman primates show the same dose- and topography-dependent effects remained unknown. Critically, rhesus macaques have been shown recently to share GABAA receptor subtype distributions in the brain that, unlike rodent species, align with human findings.


Lais Berro, PhD recently demonstrated that the benzodiazepine alprazolam induces dose- and topography-dependent EEG spectral power changes in rhesus monkeys. In this webinar, Dr. Berro reviews the main behavioral models used in her laboratory to investigate the anxiolytic, sedative and abuse-related effects of benzodiazepine drugs. She correlates her findings with recent data obtained using telemetry-based EEG recording, with the goal of promoting EEG evaluation in nonhuman primates as a valuable and translational model for studying benzodiazepine pharmacology.


Key Topics Include:
- Gain a conceptual understanding of benzodiazepine pharmacology and GABAA receptor modulation
- Become familiar with the main models used to investigate the behavioral effects of benzodiazepines in nonhuman primates
- Learn the dose- and topography-dependent EEG spectral power changes induced by benzodiazepine drugs across species
- Describe how benzodiazepine-induced EEG changes correlate with the different behavioral effects of these drugs

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BASIC INFORMATION OF DRUG ZOPICLONE

Zopiclone is a medication used to treat insomnia and sleep disorders. However, what happens if you take Zopiclone and stay awake? In this video, we'll explore the effects of Zopiclone on the body and brain, as well as the potential risks and side effects of staying awake after taking this medication.
We'll also discuss the importance of following your doctor's instructions and avoiding misuse of prescription drugs. Whether you're currently taking Zopiclone or considering it as a treatment option, this video will provide you with valuable information to help you make informed decisions about your health and well-being.

General information regarding Zopiclone (Imovane and Zimovane). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

Experts in the field of insomnia consider the efficacy of “Z-drugs” in treating insomnia, and the adverse effects of prescription medications.

Depression brought about by sleeping pills last night took a sleeping pill together want to sleep no more last night and most mornings I wake up slightly depressed it's because of the zopiclone have to learn to live with it she's all them please comment rate and subscribe

Sarah is an Entrepreneur from Australia. This is her experience with attempting to discontinue the use of the drug Zopiclone.

A review of the medication Zopiclone for the treatment of insomnia from my own personal experience.
I am not a medical professional and this is not medical advice, but merely my views having taken it.
If you have any queries please talk them over with your doctor!
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Short term treatment of insomnia in adults, including difficulties in falling asleep, nocturnal awakening and early awakening, transient, situational or chronic insomnia, and insomnia secondary to psychiatric disturbances, in situations where the insomnia is debilitating or is causing severe distress for the patient. Long term continuous use is not recommended.

Zopiclone | Non Benzodiazepine | Insomnia | Sleeping Disorder | Use | Dose | Side effect | info



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ZOPICLONE (IMOVANE): Review-Uses-Side Effects- Mechanism of Action- Withdrawal- For Insomnia Anxiety

What is zopiclone used for?
Zopiclone is a type of sleeping pill that can be taken to treat bad bouts of insomnia. It helps you fall asleep more quickly, and also helps stop you waking up during the night. Zopiclone comes as tablets.

How does zopiclone work?
Zopiclone boosts the effectiveness of a chemical in the brain called gamma-aminobutyric acid (GABA).
GABA blocks transmission across nerves in the brain and has a calming effect.

Is zopiclone good for anxiety?
Zopiclone reduces day time anxiety; has low frequency of rebound insomnia.

What are the side effects of taking Zopiclone?
SIDE EFFECTS: Daytime drowsiness, dizziness, lightheadedness, bitter taste, dry mouth, headache or stomach upset may occur the first few days as your body adjusts to the medication. If any of these effects continue or become bothersome, inform your doctor.

Is zopiclone a narcotic?
Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone.

What does zopiclone do to the brain?
Zopiclone is a type of medicine called a non-benzodiazepine hypnotic. It acts in the brain to aid sleep. Zopiclone works by increasing the activity of a neurotransmitter called GABA in the brain.

Does zopiclone knock you out?
Mental effects Zopiclone helps you sleep, though users who manage to stay awake on it can feel drowsy and calm.

Is it okay to take Zopiclone every night?
You can take zopiclone with or without food. It's important to take it exactly as your doctor has told you. You could be asked to take a tablet on only 2 or 3 nights each week, rather than every night.

Who should not take Zopiclone?
Zopiclone 7.5mg tablets is contraindicated in patients with myasthenia gravis, respiratory failure, severe sleep apnoea syndrome, severe hepatic insufficiency and those people with a hypersensitivity to zopiclone or to any of the excipients. As with all hypnotics, Zopiclone 7.5mg tablets should not be used in children.

Why is zopiclone banned in US?
Lunesta 3 mg had an impairing effect almost as large as zopiclone 7.5 mg, a similar insomnia drug. Zopiclone, which is not approved in the United States, causes consistent psychomotor impairment such that it is often used as a positive control in driving impairment studies.

Does zopiclone make you tired the next day?
Precautions – while you are taking zopiclone
Extra care is needed when taking zopiclone because it can cause sleepiness and affect your concentration the next day.

Is zopiclone linked to dementia?
According to manufacturers' literature, memory loss has been reported shortly after taking zopiclone. The incidence of these reactions is known to be rare and may be more likely to occur in elderly patients.

What is a good substitute for Zopiclone?
Eszopiclone, a stereoisomer of zopiclone, is a non-benzodiazepine hypnotic agent of the cyclopyrrolone family. Similar to zopiclone, eszopiclone is a synthetic compound shown to be effective in treating insomnia

What is the maximum zopiclone you can take?
Zopiclone is typically prescribed in the range of 5 mg to 7.5 mg daily and at 3.75 mg daily for the elderly. While zopiclone is a highly effective sleep aid, there is controversy about the extent of its addiction potential.

How long does Zopiclone 3.75 take to wear off?
The lowest effective dose should be used. Zopiclone should be taken in a single dose and not re-administered during the same night. Treatment with zopiclone should be as short as possible.

How many hours sleep with Zopiclone?
Zopiclone can affect your recent memory, especially if you do not go to bed just after taking it, or if your sleep gets interrupted. Make sure that you can get seven to eight hours of uninterrupted sleep if you are going to take zopiclone.

What happens when you stop taking Zopiclone?
Stopping zopiclone suddenly may cause withdrawal side effects. After taking zopiclone for insomnia, you may have difficulty sleeping (rebound insomnia) for the first few nights after you stop taking it.

What are the side effects of long term use of zopiclone?
Over the long term, zopiclone abuse can result in symptoms including chest pain; heart palpitations; nightmares; amnesia; abdominal pain; constipation; sinusitis; sore throat; dry mouth; lethargy; back pain; flu-like symptoms

Is it safe to take Zopiclone long term?
Zopiclone and some benzodiazepines, such as temazepam and triazolam, are indicated for the short-term treatment of insomnia. Long-term use of these medicines should be avoided

What drugs interact with Zopiclone?
alcohol.
amiodarone.
anti-anxiety medications (e.g., alprazolam, clonazepam, lorazepam)