Leflunomide Side Effects

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LEFLUNOMIDE - -- Generic Name, Brand Names , Precautions , How to use, Side Effects Side Effects 0 Views • 21 days ago

Doctors are to Blame for Outlandish Drug Prices! Side Effects 0 Views • 21 days ago

In most commodity markets, increasing competition drives the price of resources down to the benefit of consumers, but in the pharmaceutical market for MS drugs, something insidious is happening. In 1993, the first MS disease modifying therapy came onto the market (Betaseron©), but now there are twenty-two FDA-approved drugs. Despite this plethora of options from several manufacturers, the prices are climbing rapidly toward an absurd $100,000 per year. This video argues that doctors are largely to blame for this phenomenon.

Selected sources:

leflunomide is a more potent inhibitor of mitochondrial respiration than teriflunomide (isolated liver mitochondria in rats) https://cmsc.confex.com/cmsc/2....013/webprogram/Paper (Poster at CMSC by SANOFI!)

With Aubagio, “Elevations above 3 times the upper limit of normal occurred in 6%” https://www.ncbi.nlm.nih.gov/books/NBK548525/

With Arava, “An increase in ALT greater than or equal to three times the ULN was observed in 3.8%” https://www.accessdata.fda.gov..../drugsatfda_docs/lab

Teriflunomide exposure after a single 20 mg dose of leflunomide was about 70% of that after a single 20 mg dose of teriflunomide: https://www.ema.europa.eu/en/d....ocuments/assessment-

Article examining regulatory agencies and Arava vs. Aubagio: https://www.nzma.org.nz/journa....l-articles/the-cost-

Teriflunomide (AUBAGIO). Multiple sclerosis: just a metabolite of leflunomide: https://pubmed.ncbi.nlm.nih.gov/25897452/

From Leflunomide to Teriflunomide: Drug Development and Immuno-suppressive Oral Drugs in the Treatment of Multiple Sclerosis: https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC56520

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My book "Resilience in the Face of Multiple Sclerosis" on Amazon: https://www.amazon.com/dp/B07WP7H5LK

Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: https://youtu.be/wy9FL1-jup4 T

he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

Prednisone vs. Methotrexate: Which is Worse? Side Effects 0 Views • 21 days ago

#PrednisonevsMethotrexate #Methotrexate #prednisonesideeffects
💊Get Dr. Megan's Prednisone Supplement: https://www.amazon.com/Nutranize-Supplement-Magnesium-Methylfolate-Picolinate/dp/B0DZT7MTVD?maas=maas_adg_5ACF443671BBDD141C348BA4DA1F7294_afap_abs&ref_=aa_maas&tag=maas
#prednisonesideeffects #prednisonemoonface#moonface

❓What's YOUR #1 Prednisone Mistake?
Take the Quiz: https://quiz.prednisonepharmacist.com/sf/1b6e939f

This video provides information regarding the consideration of Methotrexate over prednisone as a long-term treatment option, particularly for rheumatoid arthritis. Additionally, a video may be useful for information and understanding on how to make every milligram count.

Chapters:
(0:00-2:30) Introduction to Methotrexate and Prednisone
(2:30-8:31)Making the best use of Prednisone treatment

Key Takeaways:
1. Methotrexate is considered a safer option for long-term treatments like rheumatoid arthritis compared to prednisone.
2. Patients should watch a video on how to make the best use of prednisone treatment to maximize health outcomes.

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* ☑ Are You Making the Top 7 Prednisone Mistakes? Get Your Prednisone Checklist: https://prednisonepharmacist.c....om/prednisone-wellne

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*The information contained herein is for informational purposes only and should not be construed as medical advice. Please consult your physician for any health problems and before making any medical or lifestyle changes.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Methotrexate for Rheumatoid Arthritis and Psoriatic Arthritis Side Effects 0 Views • 21 days ago

Methotrexate is one of the most common medications used for patients with inflammatory arthritis like rheumatoid arthritis or psoriatic arthritis.
#methotrexate #rheumatoidarthritis #psoriaticarthritis

If you are interested to learn more subscribe to my channel https://www.youtube.com/channe....l/UC4s5oHh_8U_xWJ7UY

In this video, I will answer the most common questions related to methotrexate therapy:

0:00 Intro
2:17 --What is Methotrexate?
2:44 --What is the effect of Methotrexate in Arthritis Patients?
3:51 --Is Methotrexate a pill or an injectable medication?
4:46 --Is Methotrexate a “chemo” drug?
5:17 ---Can Methotrexate be combined with other medications such as biologics?
6:03 ---What are the most common side effects?
7:51 ----How to monitor if methotrexate is safe for your body?
8:22 ----Can methotrexate affect your organs?
10:05 ----Why do you need to take folic acid with methotrexate?
10:58 ---Can you drink while taking methotrexate?
11:32 ---Can you get more infections while taking methotrexate?
12:21 ----Can you get vaccinated while taking methotrexate?
12:52 ----Is Methotrexate safe for pregnancy?

Sign up to My Arthritis Wellness online course: https://www.myarthritiswellnes....s.com/from-pain-to-f

Free E-book: https://www.myarthritiswellnes....s.com/the-rheumatoid

Facebook Group: Autoimmune Disease and Arthritis Support Group
https://www.facebook.com/groups/3685130571554200

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Please note - we do not provide medical advice, opinions or diagnosis via email, phone or social media messaging.We are seeing patients in multiple US states (currently 10 states). Please check our website to see if we are evaluating and treating patients in your state.

👩🏻‍⚕️ About me:
Dr Diana Girnita is a double board certified physician in rheumatology and internal medicine. She completed a PhD in immunology, a postdoctoral fellowship at Harvard University, immunology fellowship at University of Pittsburgh and rheumatology fellowship at University of Cincinnati. Dr. Girnita graduated from the Nutrition Science course from Stanford University and a Mindfulness course from The University of Massachusetts; She is the founder & CEO of Rheumatologist OnCall, a practice focused on broadening access to rheumatology and offering patients an integrative medicine approach.
Dr. Girnita teaches patients about autoimmune disease, arthritis and also helps them customized their treatment plans. Dr. Girnita is passionate about rheumatoid arthritis. The treatment plan is personalized to the patients needs and incorporates the proper nutrition, exercise and management of stress. After all,
"You have a disease, but YOU are not the disease"

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a medical consultation. Any comments and/or recommendations made in the comment section by anyone other than Rheumatologist OnCall does not reflect our opinion or recommendation.**

Scared of methotrexate? Stop hiding from it and learn how it may (or may not) be the med for you Side Effects 0 Views • 21 days ago

Methotrexate: friend or foe? If you're battling autoimmune diseases like rheumatoid arthritis or lupus, this episode is a must-watch. We delve into methotrexate’s history, how it combats autoimmune diseases, and what to expect when taking this medication.

🔗 Links:
Your Appointment Home Run Handbook - https://bit.ly/4heAouK
The guide you need to tell your doc your story -and get answers once and for all!

🎥 watch more:
How to treat Rheumatoid Arthritis pt 1: https://youtu.be/nfEgg4UY1nE
How to treat Rheumatoid Arthritis pt 2: https://youtu.be/padypfbiqb0

💡Video Key Takeaways
✔️ Methotrexate has a long history of use in treating various rheumatic autoimmune diseases since its development in the 1950s.
✔️ Its mechanism of action remains somewhat uncertain, initially believed to involve folic acid deprivation but newer mechanisms not related to folic acid have also been suggested, all leading to its recognized anti-inflammatory effects.
✔️ Methotrexate is considered standard of care in conditions like rheumatoid arthritis, psoriatic arthritis, and lupus, particularly when inflammation in the joints is a defining feature of the disease.
✔️ Administration typically involves weekly doses, either orally or via injection, with dosage starting low and gradually titrating up.
✔️ While methotrexate is effective, it can cause side effects such as nausea, mouth ulcers, liver inflammation, low cell counts, and lung injury, which require monitoring and management.

⏱️Time Stamps:
0:00 Intro
00:50 How Methotrexate Works
2:24 Why we use Methotrexate
3:44 How to take Methotrexate
6:32 Methotrexate Side Effects

📖 References:
Kalantzis, A., Marshman, Z., Falconer, D. T., Morgan, P. R., & Odell, E. W. (2005). Oral effects of low-dose methotrexate treatment. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 100(1), 52–62.
Ancuta, I. et al. The Amazing history of methotrexate - 75 years later from its discovery, still the “golden standard” therapy. Romanian Journal of Military Medicine. Feb 2023, No. 1.

**Please note - we do not provide medical advice, opinions or diagnosis via email, phone or social media messaging.

👩🏻‍⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.**