Doctors are to Blame for Outlandish Drug Prices!

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In most commodity markets, increasing competition drives the price of resources down to the benefit of consumers, but in the pharmaceutical market for MS drugs, something insidious is happening. In 1993, the first MS disease modifying therapy came onto the market (Betaseron©), but now there are twenty-two FDA-approved drugs. Despite this plethora of options from several manufacturers, the prices are climbing rapidly toward an absurd $100,000 per year. This video argues that doctors are largely to blame for this phenomenon.

Selected sources:

leflunomide is a more potent inhibitor of mitochondrial respiration than teriflunomide (isolated liver mitochondria in rats) https://cmsc.confex.com/cmsc/2....013/webprogram/Paper (Poster at CMSC by SANOFI!)

With Aubagio, “Elevations above 3 times the upper limit of normal occurred in 6%” https://www.ncbi.nlm.nih.gov/books/NBK548525/

With Arava, “An increase in ALT greater than or equal to three times the ULN was observed in 3.8%” https://www.accessdata.fda.gov..../drugsatfda_docs/lab

Teriflunomide exposure after a single 20 mg dose of leflunomide was about 70% of that after a single 20 mg dose of teriflunomide: https://www.ema.europa.eu/en/d....ocuments/assessment-

Article examining regulatory agencies and Arava vs. Aubagio: https://www.nzma.org.nz/journa....l-articles/the-cost-

Teriflunomide (AUBAGIO). Multiple sclerosis: just a metabolite of leflunomide: https://pubmed.ncbi.nlm.nih.gov/25897452/

From Leflunomide to Teriflunomide: Drug Development and Immuno-suppressive Oral Drugs in the Treatment of Multiple Sclerosis: https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC56520

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My book "Resilience in the Face of Multiple Sclerosis" on Amazon: https://www.amazon.com/dp/B07WP7H5LK

Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: https://youtu.be/wy9FL1-jup4 T

he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

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