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Scared of methotrexate? Stop hiding from it and learn how it may (or may not) be the med for you
Methotrexate: friend or foe? If you're battling autoimmune diseases like rheumatoid arthritis or lupus, this episode is a must-watch. We delve into methotrexate’s history, how it combats autoimmune diseases, and what to expect when taking this medication.
🔗 Links:
Your Appointment Home Run Handbook - https://bit.ly/4heAouK
The guide you need to tell your doc your story -and get answers once and for all!
🎥 watch more:
How to treat Rheumatoid Arthritis pt 1: https://youtu.be/nfEgg4UY1nE
How to treat Rheumatoid Arthritis pt 2: https://youtu.be/padypfbiqb0
💡Video Key Takeaways
✔️ Methotrexate has a long history of use in treating various rheumatic autoimmune diseases since its development in the 1950s.
✔️ Its mechanism of action remains somewhat uncertain, initially believed to involve folic acid deprivation but newer mechanisms not related to folic acid have also been suggested, all leading to its recognized anti-inflammatory effects.
✔️ Methotrexate is considered standard of care in conditions like rheumatoid arthritis, psoriatic arthritis, and lupus, particularly when inflammation in the joints is a defining feature of the disease.
✔️ Administration typically involves weekly doses, either orally or via injection, with dosage starting low and gradually titrating up.
✔️ While methotrexate is effective, it can cause side effects such as nausea, mouth ulcers, liver inflammation, low cell counts, and lung injury, which require monitoring and management.
⏱️Time Stamps:
0:00 Intro
00:50 How Methotrexate Works
2:24 Why we use Methotrexate
3:44 How to take Methotrexate
6:32 Methotrexate Side Effects
📖 References:
Kalantzis, A., Marshman, Z., Falconer, D. T., Morgan, P. R., & Odell, E. W. (2005). Oral effects of low-dose methotrexate treatment. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 100(1), 52–62.
Ancuta, I. et al. The Amazing history of methotrexate - 75 years later from its discovery, still the “golden standard” therapy. Romanian Journal of Military Medicine. Feb 2023, No. 1.
**Please note - we do not provide medical advice, opinions or diagnosis via email, phone or social media messaging.
👩🏻⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.
** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.**
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