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- Hydroxytryptophan
- Serious
- Other
Trials assessing colchicine for recurrent ischemic stroke prevention
Aristeidis Katsanos, MD, PhD, McMaster University, Hamilton, Ontario, Canada, introduces ongoing randomized, controlled trials investigating the efficacy of anti-inflammatory drug colchicine for the secondary prevention of ischemic stroke. The drug received attention in the stroke community after the Colchicine Cardiovascular Outcomes Trial (COLCOT) (NCT02551094) found 0.5mg/day colchicine over a two-year period can reduce the risk of stroke by 50% in patients with myocardial infarction. This inspired the CHANCE-3 (NCT05439356) trial in China which assessed the efficacy of low-dose colchicine over 90 days, in patients with a history of ischemic stroke or transient ischemic attack. Results presented at WSC 2023 show that colchicine use was not associated with a reduction in subsequent strokes at 90 days. Dr Katsanos hypothesizes that the neutral result could be due to the short trial duration. CONVINCE (NCT02898610) and RIISC-THETIS (NCT05476991) are ongoing trials with longer duration which will hopefully produce positive results, making colchicine a low cost and readily available preventative treatment for ischemic stroke patients. This interview took place at the World Stroke Congress (WSC) 2023 in Toronto, Canada.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
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