Secukinumab review.
Generic name: secukinumab.
Brand name: Cosentyx.
Dosage form: injection, intravenous infusion.
Drug class: Interleukin inhibitors.

What is secukinumab?

Secukinumab (Cosentyx) is used to treat types of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis, which are autoimmune conditions. Cosentyx is an immunosuppressant medicine that reduces the effects of a chemical substance in the body that can cause inflammation.

Secukinumab is from a group of medicines called interleukin (IL) inhibitors, and works by blocking the activity of a protein called IL-17A. People who have autoimmune conditions have increased levels of this protein. By blocking the protein's activity, it reduces inflammation, pain, swelling, and skin symptoms that you may have.

Secukinumab is available as a subcutaneous injection (an injection under the skin) and as an intravenous (IV) formulation.

What is secukinumab used for?

Secukinumab is FDA approved to treat:

moderate to severe plaque psoriasis in patients 6 years and older who are candidates for systemic therapy or phototherapy.
active psoriatic arthritis (PsA) in patients 2 years of age and older.
adults with active ankylosing spondylitis.
adults with active non-radiographic axial spondyloarthritis (nr-axSpA) and objective signs of inflammation.
active enthesitis-related arthritis (ERA) in patients 4 years of age and older .

This medicine may improve your psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis, and enthesitis-related arthritis, but it may also lower the ability of your immune system to fight infections.

Secukinumab side effects

Common secukinumab side effects may include diarrhea or cold symptoms such as stuffy nose, sneezing, and sore throat.

How should I use secukinumab?

Use secukinumab for self-administration exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Ask your doctor or pharmacist if you don't understand how to use an injection.

If you prefer to have a healthcare provider administer Cosentyx to you, it is available as a monthly, 30-minute, intravenous infusion requiring no pre-medication and no laboratory monitoring.

Subcutaneous secukinumab.

Cosentyx for self-administration at home is injected under the skin (subcutaneous injection).

Take the injection pen out of the refrigerator and let it reach room temperature for 15 to 30 minutes before use. Give the injection within 1 hour after removing the medicine from the refrigerator. Do not try to warm the medication by heating it in a microwave, placing it in hot water, or through any other method.
Prepare an injection only when you are ready to give it. You may need to use 2 injections to get your total dose.
The solution should be clear or light-yellow. Call your pharmacist if the liquid in your vial, pen, or syringe looks cloudy, has changed colors, or has particles in it.
Do not shake the syringe or dosing pen.
The injection can be given anywhere on the front of your thighs (upper leg), upper outer arms, or abdomen (stomach) except your navel and the area 2 inches (5 centimeters) around it. Do not inject into the same place two times in a row. Avoid injecting into the skin that is hard, red, bruised, swollen, tender, or affected by psoriasis.
Throw away a prefilled syringe or injection pen after one use, even if there is still medicine left inside.
Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of them following state or local laws. Keep out of the reach of children and pets.

You may get infections more easily, even serious infections. You will need frequent medical tests.

Dosing information.

Your dosage of secukinumab depends on which condition you are treating, your age, weight and sometimes how well your treatment is responding to treatment. If you have a loading dose you will be given a weekly dose on weeks 0, 1, 2, 3 and 4 and then have injections every 4 weeks. If you do not have a loading dose your injections will be every 4 weeks.

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