Celebrex Side Effects


In this episode of Drug Talk, I'm covering a request by the name of celecoxib or Celebrex.
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Celecoxib
Generic Name: celecoxib
Trade Name: Celebrex
Indication: osteoarthritis, rheumatoid arthritis, acute pain
Action: decreases pain and inflammation by inhibiting synthesis of prostaglandins
Therapeutic Class: antirrheumatics/NSAID
Pharmacologic Class: none
Nursing Considerations:
use caution with cardiovascular disease
increases risk for MI, CVA, thrombosis
may cause GI bleeding, Stevens-Johnson syndrome, dermatitis
notify provider for new-onset abdominal pain or black stool


What Is Celecoxib Used For? In this informative video, we will discuss celecoxib, a medication often used to manage pain and inflammation. Celecoxib belongs to a category of nonsteroidal anti-inflammatory drugs (NSAIDs) known as COX-2 inhibitors. We will explore its primary applications, including how it aids in the treatment of various types of arthritis, providing relief from symptoms such as pain and stiffness. Additionally, we will cover its use in treating acute pain from injuries or surgeries and its effectiveness in alleviating menstrual discomfort.
Moreover, we will touch on the potential role of celecoxib in cancer prevention, particularly in patients with familial adenomatous polyposis. Understanding how celecoxib works is essential, as it selectively targets the COX-2 enzyme, which plays a significant role in pain and inflammation management while minimizing the risk of gastrointestinal side effects commonly associated with traditional NSAIDs.
However, it’s important to be aware of the potential cardiovascular risks linked to celecoxib use. We will emphasize the importance of consulting with a healthcare provider before incorporating this medication into your pain management regimen, especially for those with existing health conditions. Join us for this engaging discussion and subscribe to our channel for more helpful information on pain medicine and management.
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Drug class,
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What is CELEBREX ? ,
Vital information,
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How to use ,
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What Are The Side Effects Of Celecoxib? In this informative video, we will discuss the side effects associated with Celecoxib, a medication commonly used in orthopedic care for conditions like osteoarthritis and rheumatoid arthritis. Celecoxib is known for its pain-relieving properties, but understanding its potential adverse effects is essential for anyone considering this treatment option.
We will cover various aspects, including gastrointestinal effects, cardiovascular risks, renal and fluid-related concerns, musculoskeletal effects, as well as ocular and allergic reactions that may arise from its use. Knowing these side effects can help you make informed decisions about your treatment plan and ensure that you are aware of what to monitor while on this medication.
For those considering Celecoxib, we will share practical considerations regarding dosing and monitoring practices to help minimize risks. Regular check-ups and communication with healthcare providers are key to ensuring safety and efficacy during treatment.
Join us as we navigate through the important information related to Celecoxib and its side effects. Remember to subscribe to our channel for more helpful discussions on orthopedic medications and health tips.
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NSAIDs stands for non-steroidal anti-inflammatory drugs. They are medications that treat inflammation in the body but are not steroids. These are drugs like ibuprofen or Motrin, naproxen or Aleve and celecoxib or Celebrex.
There’s been a growing body research showing that people who are depressed have higher levels of inflammatory chemicals in the body. Also people with infection and autoimmune disorders have an increased risk of developing depression.
Autoimmune means your body forms antibodies to your own tissues in your body. Examples of autoimmune disorders are rheumatoid arthritis, Lupus and multiple sclerosis. Even psoriasis, which is a skin disorder, is autoimmune. So groups of people with these disorders have been studied and we’ve seen a higher incidence of depression in these groups of people.
There was a 2019 study that analyzed several randomized control trials using anti-inflammatory medications to treat depression both as an add on agent and as the only medication used – we call this monotherapy. The results showed improvement in depression with the use of NSAIDs, with celecoxib rising to the top as the one used the most. The dose used was 200mg bid.
Here’s how the drug works. NSAIDs block the enzyme, cox-2 that makes prostaglandins. Prostaglandins are chemicals that contribute to arthritis pain, fever, and pain caused by inflammation. With lower concentrations of prostaglandins, you have less inflammation, less pain and less depression. Celebrex blocks the enzyme that makes prostaglandins, so you get lower concentrations of prostaglandins.
We don’t have a complete understanding of how inflammation causes depression or vice versa. It’s not clear which comes first. So understanding this is a work in progress. And this is one reason using anti-inflammatory medications isn’t a mainstream recommendation.
Side effects
NSAIDs increase the risk of gastrointestinal bleeding. And this is something that can happen anytime during the use of the medication and not just with chronic use. Even if you don’t get bleeding, you can get pretty serious stomach upset.
Also, many of the later NSAIDs like Celebrex and Vioxx cause an increase in strokes and heart attacks. In fact Vioxx was taken off the market in 2004 because of this problem. Celebrex has remained on the market but it and other NSAIDs have a black box warning about the risk of stroke and heart attack.
A black box warning is issued by the FDA and required to go on the package information. It’s a way to emphasize serious drug side effects to insure that you are informed of the risks.
References:
Müller N. COX-2 Inhibitors, Aspirin, and Other Potential Anti-Inflammatory Treatments for Psychiatric Disorders. Front Psychiatry. 2019;10:375. Published 2019 May 31. doi:10.3389/fpsyt.2019.00375
O. Köhler‐Forsberg et. al. Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials. Acta Psychiatr Scand. 2019 May;139(5):404-419.
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Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.
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NCLEX Review: Celecoxib (Celebrex) - Mechanism of Action, Uses, Side effects, and Nursing considerations
Action: 0:19
Uses: 1:55
Side effects: 2:29
Interactions: 2:59
Contraindications: 3:13
Nursing considerations: 3:44
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A discussion of which conditions Celebrex is used to treat, how it works, and dosing tips.
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Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug. It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.
In this video, let’s find found:
What is Celecoxib?
What is Celecoxib used for?
Contraindication
What are the side effects of taking Celecoxib?
How does Celecoxib work?
How to use Celecoxib?
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Tags: ankylosing spondylitis (AS), back pain, chronic back pain, menstrual distress, dysmenorrhea, muscle spasms, non-articular rheumatic muscle spasms, osteoarthritis (OA), pain, post traumatic pain, postoperative pain, rheumatoid arthritis, spinal pain


We know that NSAIDs can inhibit both COX-1 and COX-2 enzymes. But these enzymes perform slightly different functions, and it seems that inhibition of COX-2 leads to the beneficial affects of NSAIDs while inhibition of COX-1 leads to the unwanted side effects. Well what if we could take advantage of slight discrepancies in the two active sites to inhibit only one enzyme and not the other? In fact it's been done! However, so far the results are not as promising as hoped. In fact, one such drug, Vioxx, was the subject of the largest drug recall in history. Let's get a closer look at this and other COX-2 selective inhibitors.
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Celebrex contains the active ingredient celecoxib, which is a type of medicine known as a non-steroidal anti-inflammatory drug, or NSAID for short.
Celebrex is used to reduce inflammation and pain associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, which is a form of arthritis that affects the joints of the spine.
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Thank you for watching!


Use of Celebrex and other NSAIDs for treatment of rheumatoid arthritis and heart warnings.
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What Are Celecoxib's Side Effects? In this informative video, we will discuss the side effects associated with celecoxib, commonly known as Celebrex. As a nonsteroidal anti-inflammatory drug (NSAID), celecoxib is primarily used to alleviate pain and inflammation, particularly in conditions like osteoarthritis and rheumatoid arthritis. While it can be effective for pain management, it is essential to be aware of the potential side effects that may arise from its use.
We will cover both common and serious side effects, providing you with the information needed to make informed decisions about your treatment. Understanding these side effects is vital for anyone considering celecoxib, especially those with pre-existing health conditions. We will also address the importance of discussing any other medications you may be taking with your healthcare provider to ensure safe management and minimize risks.
Join us as we navigate through the benefits and risks of celecoxib, helping you understand how to use this medication safely and effectively. Don’t forget to subscribe to our channel for more essential information on pain medicine and management.
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#Celecoxib #Celebrex #PainManagement #NSAIDs #PainRelief #SideEffects #MedicationSafety #Osteoarthritis #RheumatoidArthritis #DrugInteractions #Healthcare #ChronicPain #PatientEducation #HealthTips #PainMedicine #Pharmacy
About Us: Welcome to Pain Medicine Network, your trusted source for comprehensive information on pain management and treatment options. Our channel is dedicated to exploring the latest advancements in pain medicine, offering insights into innovative therapies, research breakthroughs, and expert interviews.
Please note that our content is purely informational and should not be considered medical advice. Always consult a healthcare professional for personalized guidance and do your own due diligence when it comes to your health and treatment options. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.


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- This is lesson n# 48 in "A DRUG IN BRIEF" Series. In this video I'm gonna discuss almost all you need to know about Celecoxib ( Celebrex ): What is Celecoxib Used For, Dosage, Side Effects, Precautions and mechanism of action
- In less than 3 minutes you'll learn:
- What is Celecoxib ( Celebrex )?
- Celecoxib is a Antiinflammatory, analgesic, COX-2 inhibitor. It works by inhibiting chemicals in the body that cause inflammation, fever, and pain. This is caused by the inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2) isoenzyme.
- It is available as 100 and 200 mg capsules.
- It is used in the relief of symptoms of osteoarthritis, and rheumatoid arthritis in adults, and used in management of acute pain and primary dysmenorrhea..
- Learn more about Celecoxib ( Celebrex ) mechanism of action, uses, dosage, side effects, and precautions in this video...
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https://www.findatopdoc.com/Me....dical-Library/Drugs- - Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis.Visit www.FindaTopDoc.com today to learn more about Celebrex Drug.
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In this episode, I discuss a medication known as Celebrex (celecoxib) and go over three things that patients should be aware of before using it:
1. GI Side Effects
2. Black Box Warning
2. Heart Attack risk
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This video covers the side effects of Celebrex. Namely, I'm going to cover what I find to be the 5 'big ticket' side effects (most common and most serious).
Celebrex has been on the market for a while so we have a lot of experience with it. And it's widely available in generic form (celecoxib).
As always I appreciate you chiming in down in the comments with your experiences.


Celecoxib, also known by the brand name Celebrex, is a prescription pain medication that's used to temporarily relieve aches and pains from certain conditions, such as different types of arthritis and menstrual cramps. Celebrex (celecoxib) is a non-steroidal anti-inflammatory drug (NSAID), but it has a lower risk of causing stomach upset than other medications in its drug class, such as naproxen.
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A brief overview of the stomach and intestinal side effects and related cautions that may occur with all NSAIDs, including Celebrex.
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