The families of people who have died while taking an antipsychotic drug have told Channel 4 News there needs to be a wholesale change in how it's monitored. Around 37,000 people in the UK are prescribed clozapine, which is primarily used to treat drug-resistant schizophrenia.

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Its benefits are huge, but it's a high-risk medicine and without proper monitoring those risks can be fatal. The drug has been linked to some 400 deaths a year since its approval for use here.

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We’re delighted to be joined by Dr Sophie Legge and Dr Antonio Pardiñas for our latest minisode to discuss their latest research study.Sophie, Antonio and colleagues at Cardiff University’s MRC Centre for Neuropsychiatric Genetics and Genomics examined genetic data from more than 500 people of African descent taking clozapine, an anti-psychotic medication prescribed to people with treatment resistant schizophrenia.Clozapine is currently the most effective treatment for people with treatment-resistant schizophrenia, but it can cause a rare side effect called neutropenia. In the most extreme cases, this can develop into agranulocytosis; a severe and potentially life-threatening condition.These side-effects are characterised by lower neutrophil levels, a type of white blood cell, and these lower levels appear to be more common in people of African descent. The team were interested in learning whether genetic factors were at play, and in this minisode Sophie and Antonio explain what they found and how their results could help improve the management of clozapine treatment.For links and resources mentioned in this episode, visit https://www.ncmh.info/podcastWe hope you enjoy and we would be really grateful if you could leave us a review and help others find our podcast! If you've got any questions about this episode, get in touch at [email protected].

Clozapine is an antipsychotic medicine. Clozapine tablets ip uses to treat several metal disorders which are discussed in this video.
Clozapine tablets ip strength
1. Clozapine 12.5 mg tablet
2. Clozapine 25 mg tablet
3. Clozapine 50 mg tablet
4. Clozapine 100 mg tablet
5. Clozapine 200 mg tablet
Clozapine tablets brand names
1. Sizopin tablet
2. Skizoril tablet
3. Clozaril tablet
4. Lozapin talet
5. Zaporil tablet
This video contains information about Clozapine tablets ip | Clozapine tablets 100mg | clozapine side effects including
1. What is clozapine?
2. Clozapine tablet strength
3. Clozapine tablets brand name
4. Clozapine tablets ip uses in hindi
5. Clozapine tablet side effects
6. Clozapine tablets dosage
7. Clozapine tablet mechanism of action
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Full interactive content videos now available at www.psychstudentinteractive.com

This video gives an overview of the complex antipsychotic clozapine. This information is up to date at the time of publishing but for up to date information please consult your local prescribing guidance or BNF particularly if prescribing for an off-licence indication. This video describes key factors in the commencement of clozapine and side effects or problems to watch out for. Whilst in the UK clozapine must be initiated by a consultant psychiatrist ongoing prescriptions and monitoring are the responsibility of the whole team and it is a medication which is often used when writing exam questions.

Disclaimer: please ensure you are reviewing up to date guidance and local policies when prescribing and monitoring clozapine. Psychstudent takes no responsibility for prescribing or clinical decisions. This information is correct at the time of publishing for use in England.

In this video, we uncover the long-term and often irreversible effects of antipsychotic drugs, including brain volume loss, tardive dyskinesia, and cognitive decline.

Most doctors don't discuss these risks in detail, and patients are left unaware of the potential damage caused by these medications.

We’ll explore the evidence from both animal and human studies, explain how these medications affect your brain, and discuss what you can do to mitigate the risks.

If you or a loved one is on antipsychotics, this information is essential to understand the potential long-term consequences.

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🔗 LINKS MENTIONED
- Dorph-Petersen KA, Pierri JN, Perel JM, et al. (2005). The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology, 30, 1649–1661.**
- Fusar-Poli P, Smieskova R, Kempton MJ, Ho BC, Andreasen NC, Borgwardt S. Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neurosci Biobehav Rev. 2013 Sep;37(8):1680-91. doi: 10.1016/j.neubiorev.2013.06.001. Epub 2013 Jun 14. PMID: 23769814; PMCID: PMC3964856.
- Wu JQ, Chen DC, Xiu MH, Tan YL, Yang FD, Kosten TR, Zhang XY. Tardive dyskinesia is associated with greater cognitive impairment in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:71-7. doi: 10.1016/j.pnpbp.2013.06.013. Epub 2013 Jul 1. PMID: 23827756.
- https://www.psychiatrictimes.c....om/view/tardive-dysk
- Moncrieff J, Leo J. A systematic review of the effects of antipsychotic drugs on brain volume. Psychol Med. 2010 Sep;40(9):1409-22. doi: 10.1017/S0033291709992297. Epub 2010 Jan 20. PMID: 20085668.

Timestamps:
05:05 Brain Shrinkage and Its Implications
10:04 Movement Disorders: Tardive Dyskinesia Explained
15:11 Cognitive Decline and Long-Term Effects
16:33 Preventative Measures and Alternatives

‼️ DISCLAIMER: All the information on this channel is for educational and/or entertainment purposes and not intended to be specific/personal medical advice from me to you. Watching the videos, or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, these videos can maybe help you prepare for your discussion with him. We do our best to spread awareness with these videos, but for legal reasons we can’t answer health questions in the comments. If you leave questions, we’ll make videos about common questions in the future! If we catch incorrect health information, hate speech, illegal solicitation of drugs in the comments, we will remove them.

NCLEX Review: Clozapine - Mechanism of Action, Uses, Side effects, Contraindications, and Nursing considerations


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Clozapine is the single most effective antipsychotic available, and it works in treatment resistant schizophrenia where no other medication is proven to be effective. This video will tell you everything you need to know about this important medication.

Time Stamps:
Topic Intro: 00:00 to 00:32
Old Vs New Medications: 00:33 to 01:20
Efficacy of Clozapine 01:21 to 03:10
Side Effects: 03:11 to 06:39
Mechanism of Action: 06:40 to 9:28
Important steps before starting the medication: 09:29 to 12:28
Dosing: 12:29 to 14:23

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- This is lesson n# 91 in "A DRUG IN BRIEF" Series. In this video I'm gonna discuss almost all you need to know about Clozapine ( Clozaril ): What is Clozapine? Clozaril Uses, Dose, Adverse Effects, Precautions and mechanism of action

- In 3 minutes you'll learn:

- What is Clozapine ( Clozaril ): What is Clozapine? Clozapine uses, Side effects of Clozapine & Clozapine dose

- Clozapine is an antipsychotic medicine. It is a dopamine and serotonin antagonist in CNS. It also antagonizes adrenergic, cholinergic, and histaminergic neurotransmission.

- It is available as 25 mg, 50 mg,100 mg, and 200 mg tablets.

- Clozapine is used in the management of severely and chronically mentally ill schizophrenic patients who have not responded to or cannot tolerate standard antipsychotic drug treatment.

- Learn more about Clozapine ( Clozaril ) mechanism of action, uses, dosage, side effects, and precautions in this video...

- MORE "DRUG IN BRIEF" VIDEOS HERE:
https://www.youtube.com/watch?v=BM5dg5f2daE&t=2s&list=PLL3y4VLBMQfgmQqcppCvUdJvlsoQVlCvI&index=2

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In this video I talk about the 3 most serious side effects of Clozapine, those include: Agranulocytosis, Gastrointestinal hypomotility and myocarditis; Clozapine is a second generation antipsychotic medication
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Video Chapters
0:00 Introduction
0:35 Side effect 1: Agranulocytosis
2:33 Side effect 2: Gastrointestinal hypomotility
3:51 Side effect 3: Myocarditis
4:58 Other side effects

In this video we will cover everything you need to know about Clozapine, also known as Clozaril. This video is part of a video series on mental health problems. So for more mental health related videos check out this playlist:
https://www.youtube.com/playli....st?list=PLaG3Bo3L0gX

Generic name: Clozapine.
Brand names: Clozaril and Leponex.
Available as a tablet and a drink.

How to use it?
Swallow the tablet completely with half a glass of water.
When using it as a drink: measure the correct amount you need to take with a measuring spoon or measuring cup. And drink it.

Duration of treatment:
The duration of treatment depends on the indication of use and the severity of your symptoms. If your symptoms improve with the use of Clozapine you usually have to keep using it for 12-24 more months. And sometimes multiple years.

When to use it?
Clozapine is part of a group of drugs called antipsychotics. It can be used to treat several mental health conditions:
- Treatment-resistant schizophrenia.
- Treatment-resistant psychosis.
- Psychotic disorders in Parkinson's disease.
- Delirium in Parkinson's or 'Lewy body' dementia.

What is the correct dosage?
Unfortunately I can’t provide you with guidelines for the correct dosages, as these differ a lot depending on the specific indication, the side effects you experience and the severity of your complaints.
Usually your doctor starts with a low dose and quickly builds it up over a few days. Afterwards your maintenance dose will be adapted throughout your treatment based on the blood levels of Clozapine you will be having.
Therefore always use the prescribed dose and frequency your doctor gave you.

What are the side-effects?
Very common (10%): somnolence, dizziness, constipation and a fast heartbeat.
Common (1-10%): changes in your blood values, dry mouth, low blood pressure, high blood pressure, stomach and intestine complaints, weight gain, headache, tremor, stiffness, fatigue, fever and sweating.
Uncommon (0.1-1%): stuttering and falling.

Safety:
You should be careful to combine Clozapine with alcohol. As this might increase the dazing effect of Clozapine.
In addition it is usually safe to drive while using this drug, however it can cause you to become drowsy, sleepy and/or dizzy. If you experiencing any of these side effects then please do not drive.
Furthermore, smoking cigarettes decreases the effectivity of clozapine. Always discuss this with your prescribing doctor.
Lastly, Clozapine can have interactions with several drugs. Therefore always discuss this with your treating physician.

Pregnancy and Lactation:
Clozapine can be dangerous in both cases, therefore always discuss this with your doctor.

- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -

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Literature:
1: Farmacotherapeutisch Kompas. (2020). Clozapine
2: Apotheek.nl (2020). Clozapine.

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Our treatment specialist and founder of ATMC, Lyle Murphy, answers your biggest concerns about the second generation antipsychotic drug Clozapine.


Clozaril is the brand name for the active ingredient, clozapine. Other brand names include Clopine, Clozapine Synthon, and FazaClo.



Q&A From you!

00:00 - Intro
00:20 - Why do so many doctors feel that Clozapine is the most effective medication for schizophrenia?
00:58 - Is clozapine a mood stabilizer?
01:21 - What are the worst side effects of clozapine?
03:13 - Why is clozapine called an atypical antipsychotic and not a benzodiazepine?
04:19 - Can clozapine cause tremors?
05:11 - What's next for the schizophrenic when clozapine fails? Doctors seem to always have another one ready?
06:04 - Could clozapine affect one's cognitive abilities/IQ?
08:31 - Is Clozapine worth the risk for those suffering from severe schizophrenia, considering how dangerous some of the side effects are?
10:07 - What antipsychotic is a good alternative to clozapine if you have to have something?
12:24 - Why would someone be prescribed a "therapeutic" dose of clozapine?
12:53 - Is olanzapine a better antipsychotic than clozapine if you worry about your physical health most?
15:20 - Which is less likely to cause tardive dyskinesia, olanzapine 2.5mg or clozapine 25mg?
15:55 - How long do antipsychotics withdrawal symptoms last from 2 months from 100 mg of Clozapine?
17:40 - What are the chances of a low dose (25mg) of clozapine causing tardive dyskinesia?
18:09 - Does a significant weight loss change the efficacy of clozapine?
19:04 - Can hypomotility caused by clozapine affect the absorption and efficacy of it?
20:32 - Will fasting for 24 hours affect the absorption of clozapine and cause a problem?
24:25 - ATMC

Careful Clozaril withdrawal can minimize the potential for rebound psychosis and cholinergic crises. Clozaril belongs to a class of drugs called SGA’s or second-generation antipsychotics.
Used in the treatment of certain mental conditions such as schizophrenia and psychosis, Clozaril is often prescribed only AFTER other antipsychotics did not work or caused severe side effects.
Alternative to Meds has been the expert on antipsychotic withdrawal and Clozaril alternatives for over 15 years. We have published evidence regarding our success. Underlying issues can in many cases be addressed in much less toxic ways. It is possible that some medical conditions could have been overlooked. Commonly some or all of the original contributing factors have improved or changed, and the diagnosis one was given may no longer lead to recovery.


What Is Clozaril (clozapine) Used For?


Clozaril is used in the treatment of certain mental disorders, where other (usually at least two) other antipsychotic medications have not worked, or where the side effects were too harsh and could not be tolerated by the patient. A candidate for a prescription of Clozaril could be someone diagnosed with conditions such as:

Treatment-resistant schizophrenia.
Treatment-resistant schizoaffective disorder with a known risk for suicide.
Please note that elderly patients with dementia-related psychosis should NOT be prescribed Clozaril (or other antipsychotic medications) due to the increased risk of death.


Discontinuing/Quitting Clozaril (clozapine)
There are circumstances where immediate withdrawal of Clozaril is medically needed as a life-saving intervention. These include potentially life-threatening adverse reactions to the drug which are delineated in detail under the adverse effects section, for instance, cardiovascular compromise, risk of stroke, signs of tardive dyskinesia, and other severe reactions.

In the majority of cases, gradual Clozaril tapering methods are recommended for coming off the drug.

Always seek medical guidance and direction from your doctor before making changes to medications.

Read more at: https://www.alternativetomeds.com/blog/clozaril/

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Cathy covers first-generation (typical) antipsychotic medications and second-generation (atypical) antipsychotic medications.

Our Pharmacology video tutorial series is taught by Cathy Parkes BSN, RN, CWCN, PHN and intended to help RN and PN nursing students study for their nursing school exams, including the ATI, HESI and NCLEX.

#NCLEX #Pharmacology #Nervous #HESI #Kaplan #ATI #NursingSchool #NursingStudent⁠ #Nurse #RN #PN #Education #LVN #LPN #Antipsychotic

0:00 What to Expect
0:09 Symptoms of Schizophrenia & Positive Symptoms
0:36 Negative Symptoms
0:59 Typical/First Generation Antipsychotics
1:18 Mode of Action
1:44 Side Effects
3:50 Atypical/Second Generation Antipsychotics
4:49 Mode of Action & Side Effects
5:49 Nursing Care
6:12 What’s Next

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Clozapine is the most effective of all antipsychotic medications. And for many people with schizophrenia, clozapine is a game-changing treatment that makes it possible to go back to school, go back to work, live independently, or be in relationships.

It does have side effects (all medicines do), but many of them can be prevented or minimized.

Sedation is one of the most common of clozapine’s side effects, and this lecture talks possible causes and potential treatments for clozapine-associated sedation.

Here, we look at the prevalence of clozapine-associated sedation, discuss pharmacological actions of clozapine that may contribute to sedation, and survey some treatment strategies to reduce or eliminate this side effect.

If you’d like to learn more about clozapine, feel free to register for one of our free online continuing medical education events. The schedule of upcoming events is located at [https://clozapine.info/training/](https://www.youtube.com/redirect?v=HQGlvQKKQXc&redir_token=amza-r0-7tSq2dVsQQjGNF24oz98MTU4NjQzODg4NEAxNTg2MzUyNDg0&event=video_description&q=https%3A%2F%2Fclozapine.info%2Ftraining%2F)

The lecture is part of the SZconsult learning community, which meets every Tuesday at noon, eastern time. It’s a free education + consultation service of Northeast Ohio Medical University. For more information send an email to [email protected]

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Brain J. Lee, MD is a resident psychiatrist and researcher at the Johns Hopkins University School of Medicine. Here, he discusses some of the more serious metabolic side effects of clozapine with potential mitigating strategies. He is the lead study author of The Protective Effect of Clozapine on Suicide, published in The Journal of Clinical Psychiatry.

See the full-text article: https://bit.ly/3OXCmUr

Presented by The Journal of Clinical Psychiatry ​ @psychiatristcns

This is a recorded lecture. It was given at the monthly Psychosis Education Event in January, 2023. The monthly Psychosis Education Event consists of a free lecture on some mental health related topic, followed by an open-forum question/answer session with a psychiatrist and clinical psychologist. It is free of charge and open to the public. If you would like to join, send me a note via https://askapsychiatrist.info

Clozapine is the most effective medication for schizophrenia. It is the only medication with FDA approval for reducing suicide risk. About 30% of people with schizophrenia do not get significant benefit from standard antipsychotic medication -- yet in that subset of individuals, clozapine is successful in about 50% of cases (the success rate of other antipsychotic medications is about 7% to 14%).

This lecture discusses:
1. Why do some people with schizophrenia-like symptoms not respond to standard, first-line antipsychotic medications?
2. What are the unique advantages of clozapine?
3. What are the most common or worrisome clozapine side effects, and how can their risks be minimized?
4. Are there any alternatives to clozapine?

In this episode, I discuss a medication known as clozapine (Clozaril).

My book is now available! It discusses my experience with Bipolar Disorder.
The Fifth Episode - Inside The Manic Mind.
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