Sitagliptin is an oral antihyperglycemic agent used to treat type 2 diabetes mellitus. Here are some key points about its pharmacology:

Mechanism of Action
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by inhibiting the DPP-4 enzyme, which is responsible for the degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preventing the breakdown of these hormones, sitagliptin increases their levels, leading to enhanced insulin secretion in response to meals and improved glycemic control.

Pharmacokinetics
Absorption: Sitagliptin is well absorbed orally, with peak plasma concentrations typically occurring within 1 to 4 hours after ingestion.

Metabolism: It is extensively metabolized in the liver to inactive metabolites.

Excretion: The metabolites are excreted in the urine (80%) and feces.

Elimination Half-Life: The half-life is approximately 8 to 14 hours.

Indications
Sitagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also available in combination with metformin (Janumet) and other antidiabetic medications1.

Dosage
Adults: The usual dose is 100 mg once daily, taken with or without food.

Administration: Take sitagliptin at the same time each day to help you remember.

Side Effects
Common: Headache, upper respiratory tract infection, and swelling of the legs.

Serious: Hypoglycemia (especially when used with other antidiabetic medications), pancreatitis, and allergic reactions.

Contraindications
Hypersensitivity to sitagliptin or any of its components.

Type 1 Diabetes Mellitus: Not for treating type 1 diabetes mellitus.

Diabetic Ketoacidosis: Not for treating diabetic ketoacidosis.

Special Precautions
Hypoglycemia: Monitor blood glucose levels regularly and be cautious with dosing to avoid hypoglycemia.

Pancreatitis: Be aware of the signs and symptoms of pancreatitis and discontinue use if pancreatitis is suspected

#Sitagliptin

Susan Cornell, PharmD, CDE, FAPhA, FAADE, discusses the contraindications and adverse effects pharmacists should consider when recommending antidiabetic agents.

This video was filmed at APhA's 2016 Annual Meeting and Exposition in Baltimore, Maryland.

Video Terms & Conditions - Waiver and Release of Liability
All viewers of this video recognize and acknowledge that all content presented in this video is solely for educational purposes. All viewers acknowledge and agree that if any methods, techniques or protocols learned in the video is used or implemented, it is done so appropriately, with individual discretion, for its intended purposes, and only after such individual receives guidance and advice from a professional practitioner that has evaluated and considered such individual’s situation and circumstances personally. Any methods, techniques or protocols presented in this video may have inherent risks when is individually used or implemented. Any viewer who uses or implements any learned methods, techniques or protocols found in this video recognizes such risks and acknowledge professional liabilities may result from individual use or implementation of learned methods, techniques or protocols.

All viewers should be aware of the potential risks, including, but not limited to, death or permanent medical illness, that can occur by individual use or implementation of the methods, techniques or protocols presented in this video.

All viewers agree that CPG Rx LLC and/or any affiliated businesses or persons do not have any legal obligations or duties to the actions performed by any viewer after viewing this video. All viewers consent to release CPG Rx LLC and/or any affiliated businesses or persons of all liabilities and obligations associated and related to any adverse actions or professional liability incurred as a result of using or implementing the methods, techniques or protocols learned in this video.

Your doctor has prescribed Januvia to help lower your blood sugar, which is too high because of your type 2 diabetes. Januvia can be used alone or in combination with certain other medicines (insulin, glucophage, diamicron) that lower blood sugar.

A largescale new study offers a new approach to treating in type 2 diabetes - that puts patients in charge of their own medication. The Trimaster study is the first to allow people with type 2 diabetes to choose their own medication, after trying three different drugs in succession. It concluded the approach could be a new way of finding the best treatment.
Researchers at the University of Exeter led the Medical Research Council-funded study, which gave people with type 2 diabetes three commonly-prescribed drugs, each for a 16-week period in turn. During the study, researchers monitored the effect of each drug on the 448 patients’ glucose levels, weight and recorded the side effects. At the end of the study, now published in Nature Medicine, patients got to choose the drug that worked best for them. Their chosen drug not only lowered glucose most effectively, but also resulted in less side effects.
Lead author Dr Beverley Shields, of the University of Exeter, said: “Getting the right treatment for diabetes is fundamental to getting the best outcomes, and maintaining good quality of life. Our study is the first to invite people with type 2 diabetes to try common drugs in succession, to see which one works best for them. Interestingly, we found that the treatment people chose was usually the one which gave them best blood sugar control – even before they knew those results.”
Participant Tim Keehner, from North Devon, was diagnosed with type 2 diabetes 15 years ago. The marketing expert was enrolled into the study because his blood sugar was running too high
“I was given three drugs. The first two didn’t work for me at all – in fact, one of them made me feel even worse. Thankfully, from the first moment I took the third drug, I felt different – I had more energy, and I knew it was the right drug for me. I’m still on it today and I’m able to engage in all the sports I love – it’s fantastic.”
Type 2 diabetes affects more than four million people in the UK, and is a major cause of illness and death. It also accounts for 10 per cent of NHS expenditure . The problems associated with diabetes can be greatly reduced if the blood sugar levels are lowered. A number of different drugs work to reduce blood sugar, and while overall they are similarly effective, individual patients will vary in terms of how much the drug lowers their blood sugar and the side effects they have. Choosing the right drug for a patient is difficult.
Diabetes consultant Professor Andrew Hattersley CBE, of the University of Exeter, who oversaw the research, said: “This is the first study in which the same patient has tried three different types of glucose-lowering drug, enabling them to directly compare them and then choose which one is best for them. We’ve shown that going with the patients’ choice results in a better glucose control and less side effects than any other approach. When it’s not clear which drug is best to use, then patients should try before they choose. Surprisingly, that approach has never been tried before.”
The three drugs given to patients in the trial were sitagliptin, canagliflozin, and pioglitazone
The study is entitled ‘Patient preference for second/third line therapies in Type 2 diabetes: results from the TriMaster double blind randomised three-way crossover trial, and is published in Nature Medicine. The included collaboration Royal Devon University Healthcare NHS Foundation Trust, universities of Oxford, Glasgow and Dundee, Exeter NIHR Clinical Trials Unit and 24 hospitals throughout the UK..

This video is about an antidiabetic medication known as sitagliptin and its medical uses.
sitagliptin is a drug which is also known as DPP4 inhibitor because of its mode of action .
this drug inhibits enzyme dipeptidyle peptidase 4 and consequently increases level of incretins like GLP-1 and GIP which helps in lowering high blood sugar level in type2 DM patients .
#sitagliptin #drafzal
About Me
My Name Is Dr Afzal.I Graduated From Allama Iqbal Medical College Lahore.
Based On Almost 20 Years Of My Experience In Field Of Medicine I Strongly Believe That If You Want A Healthy SocietyThen First & Foremost You Need To Educate & Inform People Living Around You About Their Basic Health Problems In The Easiest Possible Way.And In This Regard I Honestly Believe There Can Not Be A Plateform As Goid As Youtube Which Helps To Bring This Dream To Reality So Here I Present Myself With The Most Updated Medical Knowledge in Simplest Possible Way.But As I Always Say Its Just An Informative Video And It Can IN WAY be a substitute Of Your Primary Physician or Your Primary Doctor.
So I Always always Request You To Please Consult Your Primary Health Care Provider In Case You Have any health Issue.
THANKS
Dr Muhammad Afzal

Vice President of Clinical Research at Merck talks about post-hoc analysis of a study that examined the efficacy of sitagliptin versus dapagiflozin.

Welcome to MediInsights, where we unlock the wonders of wellness! In this comprehensive video, we'll explore everything you need to know about Sitagliptin tablets, a powerful medication for managing type 2 diabetes.

Introduction to Sitagliptin Tablets:
Sitagliptin tablets are a commonly prescribed medication for individuals with type 2 diabetes mellitus. They help regulate blood sugar levels when diet and exercise alone aren't sufficient.

Uses of Sitagliptin Tablets:
Sitagliptin is used to improve blood sugar control in adults with type 2 diabetes. It can be used alone or in combination with other diabetes medications to enhance its effectiveness.

Dosage of Sitagliptin Tablets:
The standard dosage for Sitagliptin is 100 mg once daily. It can be taken with or without food, making it convenient for daily use. For those with renal impairment, dosage adjustments are necessary. Always follow your healthcare provider's specific dosage instructions.

Mechanism of Action:
Sitagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). This inhibition increases the levels of incretin hormones, which stimulate the pancreas to produce more insulin and reduce the amount of glucose produced by the liver. This dual action helps lower blood sugar levels, particularly after meals.

Side Effects of Sitagliptin Tablets:
Common side effects include upper respiratory infections, headaches, and nasopharyngitis. Although rare, serious side effects can occur, such as pancreatitis, severe allergic reactions, and kidney problems. It's important to monitor for any unusual symptoms and report them to your healthcare provider immediately.

Important Advice for Using Sitagliptin Tablets:

Take as Prescribed: Ensure you take Sitagliptin exactly as your doctor has prescribed.
Monitor Blood Sugar Levels: Regularly check your blood sugar levels to track your progress.
Inform Your Doctor: Let your healthcare provider know about any other medications or supplements you are taking to avoid potential interactions.
Be Aware of Pancreatitis Symptoms: Watch for signs of pancreatitis, such as severe abdominal pain, and seek immediate medical attention if they occur.
Maintain a Healthy Lifestyle: Combine your medication with a balanced diet and regular exercise for optimal results.
Conclusion:
Sitagliptin tablets play a crucial role in managing type 2 diabetes by effectively controlling blood sugar levels. Always consult your healthcare provider for personalized advice and guidance.

Stay tuned to MediInsights for more detailed information on medications and health tips. Don't forget to like, share, and subscribe to our channel to stay updated with the latest in wellness!

Hashtags: #MediInsights #Sitagliptin #DiabetesManagement #Wellness #HealthTips #UnlockingTheWondersOfWellness #BloodSugarControl #Type2Diabetes #DiabetesCare #DiabetesMedication #HealthEducation #WellnessJourney #UnlockingTheWondersOfWellness #Pharmacology #MedicationGuide #DiabetesTips #HealthyLiving #Endocrinology #PatientEducation #WellnessTips #Healthcare #diabetesawareness

Disclaimer: This video is intended for educational and informational purposes only. The content provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or the use of medications. The information presented here is based on general knowledge and research and may not be applicable to individual circumstances. The creators of this video do not endorse or promote any specific medical products or treatment regimens. Viewers are encouraged to consult their healthcare provider for personalized medical advice. The content provided in this video complies with YouTube's community guidelines and policies.

CHAPTERS:
0:00 :INTRO
0:43 :USE OF SITAGLIPTIN TABLETS
0:03 :DOSAGE OF SITAGLIPTIN TABLETS
1;23 :MECHANISM OF ACTION OF SITAGLIPTIN TABLETS
1:47 :SIDE EFFECTS OF SITAGLIPTIN TABLETS
2:09 :IMPORTANT ADVICES FOR USING SITAGLIPTIN TABLETS

TAGS:
USE OF SITAGLIPTIN TABLETS,
DOSAGE OF SITAGLIPTIN TABLETS,
MECHANISM OF ACTION OF SITAGLIPTIN TABLETS,
SIDE EFFECTS OF SITAGLIPTIN TABLETS,
IMPORTANT ADVICES FOR USING SITAGLIPTIN TABLETS,
SITAGLIPTIN TABLETS,
SITAGLIPTIN TABLETS USES,
SITAGLIPTIN TABLETS DOSAGES,
SITAGLIPTIN TABLETS MECHANISM,
SITAGLIPTIN TABLETS SIDE EFFECTS,
SITAGLIPTIN TABLETS TIPS,

Use the PharmacoPhoto video 'flash-card' series to reinforce your knowledge of drug classes and specific medications.

SITAGLIPTIN VS LINAGLIPTIN VS TENELIGLIPTIN VS VILDAGLIPTIN #drniteshraj #drnitish #diabetesmedicine

Medical Use, Dosage, Side effects, ,Drug interactions, special precautions, contraindications, Mechanism of Action, Combinations, Brand Names.