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#22998 Experience of Mirabegron in the Treatment of Neurogenic Bladder following SCI
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• 08/24/25
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Experience of Mirabegron in the Treatment of Neurogenic Bladder following SCI
Knight S1, Riley C1, Lee F1, Hamid R1
1. Royal National Orthopaedic Hospital
KEYWORDS: Spinal Cord Injury, Overactive Bladder, Incontinence
Following a spinal cord injury (SCI), disruption to the neural pathways to the bladder can result in Neurogenic Lower Urinary Tract Dysfunction (NLUTD). This can lead to reduced bladder capacity, neurogenic detrusor overactivity (NDO), incontinence and potential damage to the upper tracts. The first line treatment is anti-muscarinic medication (AM), however this can be associated with intolerable side effects such as dry mouth, blurred vision and constipation and has been implicated in the development of dementia in older patients. Additionally, AMs are contra-indicated in patients with glaucoma. A ß3 agonist, mirabegron has become available for treatment of OAB and NDO. We have been offering mirabegron (25 or 50 mg) as an alternative to AMs where the patient can no longer take them or as an additional treatment where AMs or botox are not effectively managing NDO. We present the effects of mirabegron treatment on urodynamic parameters in patients with NLTUD following SCI.
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