ACETAMINOPHEN CHLORPHENIRAMINE DEXTROMETHORPHAN:

WHAT IS ACETAMINOPHEN CHLORPHENIRAMINE DEXTROMETHORPHAN USED FOR AND HOW DOES IT WORK?

Acetaminophen chlorpheniramine dextromethorphan is an over-the-counter (OTC) product used for the relief of cold and flu symptoms.

Acetaminophen chlorpheniramine dextromethorphan is available under the following different brand names: Children's Triaminic Flu, Cough and Fever, Children's Tylenol Plus Cough and Runny Nose, Coricidin HBP Maximum Strength Flu, Vicks Formula 44 Custom Care Cough and Cold PM, and St. Joseph Maximum Strength Flu.

WHAT ARE THE DOSAGES OF ACETAMINOPHEN CHLORPHENIRAMINE DEXTROMETHORPHAN?

Dosages of Acetaminophen Chlorpheniramine Dextromethorphan:

Dosage Forms and Strengths:

Tablet:

500mg/2mg/15mg.

Dosage Considerations – Should be Given as Follows:

Relief of Cold and Flu Symptoms.

Adults and children 12 years and older: 2 tablets orally every 6 hours; not to exceed 8 tabs day.

Dosage Modifications:

Renal impairment: No dose adjustment is required.
Mild-to-moderate hepatic impairment: No dose adjustment required.
Severe hepatic impairment: Not recommended; based on the increased inherent risk of bleeding in patients with severe hepatic impairment.

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING ACETAMINOPHEN CHLORPHENIRAMINE DEXTROMETHORPHAN?

Common side effects of Acetaminophen Chlorpheniramine Dextromethorphan include:

Low blood pressure (hypotension).
Palpitations.
Fast heart rate.
Confusion.
Depression.
Distress.
Dizziness.
Euphoria.
Fatigue.
Headache.
Insomnia.
Irritability.
Sedation.
Tremors.
Skin rash.
Loss of appetite.
Gastrointestinal disturbances.
Anemia.
Blood disorders (neutropenia, pancytopenia, leukopenia, thrombocytopenia, agranulocytosis).
Hemolytic anemia.
Increased bilirubin and alkaline phosphatase.
Thickening of bronchial secretions.
Wheezing.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

WHAT OTHER DRUGS INTERACT WITH ACETAMINOPHEN CHLORPHENIRAMINE DEXTROMETHORPHAN?

Severe interactions of acetaminophen_chlorpheniramine_dextromethorphan include:

isocarboxazid.
phenelzine.
procarbazine.
rasagiline.
safinamide.
selegiline.
tranylcypromine.

Acetaminophen chlorpheniramine dextromethorphan has serious interactions with at least 38 different drugs.

Acetaminophen chlorpheniramine dextromethorphan has moderate interactions with at least 267 different drugs.

Acetaminophen chlorpheniramine dextromethorphan has mild interactions with at least 76 different drugs.

WHAT ARE WARNINGS AND PRECAUTIONS FOR ACETAMINOPHEN CHLORPHENIRAMINE DEXTROMETHORPHAN?

Warnings:

This medication contains acetaminophen chlorpheniramine dextromethorphan. Do not take Children's Triaminic Flu, Cough and Fever, Children's Tylenol Plus Cough and Runny Nose, Coricidin HBP Maximum Strength Flu, Vicks Formula 44 Custom Care Cough and Cold PM, or St. Joseph Maximum Strength Flu if you are allergic to acetaminophen chlorpheniramine dextromethorphan or any ingredients contained in this drug.

Cautions:

Caution in asthma, bladder neck obstruction, cardiovascular disease, chronic obstructive pulmonary disease (COPD), gastrointestinal obstruction, glaucoma, hepatic impairment, hypertension, hyperthyroidism, increased intraocular pressure, malnutrition, renal impairment, elderly patients, patients taking CNS depressants or children under 6 years of age with chlorpheniramine products
Caution in severe hypovolemia if taking acetaminophen products
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash.

Pregnancy and Lactation:

There is no information available regarding the use of acetaminophen chlorpheniramine dextromethorphan during pregnancy or while breastfeeding.

Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.

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