ACETAMINOPHEN CHLORPHENIRAMINE PHENYLEPHRINE

WHAT IS ACETAMINOPHEN CHLORPHENIRAMINE PHENYLEPHRINE USED FOR AND HOW DOES IT WORK?

Acetaminophen chlorpheniramine phenylephrine is an over-the-counter (OTC) product used for relief of cold and flu symptoms.

Acetaminophen chlorpheniramine phenylephrine is available under the following different brand names: Tylenol Allergy Multi-Symptom, Dristan Cold, Children's Tylenol Plus Cold, Tylenol Sinus Congestion and Pain Nighttime, and Robitussin Peak Cold Nighttime Nasal Relief.

DOSAGES OF ACETAMINOPHEN CHLORPHENIRAMINE PHENYLEPHRINE

Dosage Forms and Strengths:

Tablet:

325mg/2mg/5mg.

Dosage Considerations – Should be Given as Follows:

Relief of Cold and Flu Symptoms.

Adults and Children over 12 years:

Dristan Cold: 2 tablets orally every 4 hours; not to exceed 12 tablets day.
Tylenol Allergy Multi-Symptom: 2 tablets orally every 4 hours; not to exceed 12 tablets day.
Tylenol Sinus Congestion and Pain Nighttime: 2 tablets orally every 4 hours; not to exceed 12 tablets day.
Robitussin Peak Cold Nighttime Nasal Relief: 2 tablets every 4 hours as needed; not to exceed 12 tablets day.

Children under 12 years: Ask a pediatrician.

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING ACETAMINOPHEN CHLORPHENIRAMINE PHENYLEPHRINE?

Common side effects of Acetaminophen Chlorpheniramine Phenylephrine include:

Low blood pressure (hypotension).
Palpitations.
Fast heart rate.
Confusion.
Depression.
Distress.
Dizziness.
Euphoria.
Fatigue.
Headache.
Insomnia.
Irritability.
Sedation.
Tremors.
Skin rash.
Loss of appetite.
Gastrointestinal disturbances.
Anemia.
Blood disorders (neutropenia, pancytopenia, leukopenia, thrombocytopenia, agranulocytosis).
Hemolytic anemia.
Increased bilirubin and alkaline phosphatase.
Thickening of bronchial secretions.
Wheezing.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

WHAT OTHER DRUGS INTERACT WITH ACETAMINOPHEN CHLORPHENIRAMINE PHENYLEPHRINE?

Severe interactions of acetaminophen chlorpheniramine phenylephrine include:
iobenguane I 123.
isocarboxazid.
linezolid.
phenelzine.
procarbazine.
selegiline transdermal.
tranylcypromine.

Acetaminophen chlorpheniramine phenylephrine has serious interactions with at least 28 different drugs.
Acetaminophen chlorpheniramine phenylephrine has moderate interactions with at least 281 different drugs.
Acetaminophen chlorpheniramine phenylephrine has mild interactions with at least 64 different drugs.

WHAT ARE WARNINGS AND PRECAUTIONS FOR ACETAMINOPHEN CHLORPHENIRAMINE PHENYLEPHRINE?

Warnings:

This medication contains acetaminophen chlorpheniramine phenylephrine. Do not take Tylenol Allergy Multi-Symptom, Dristan Cold, Children's Tylenol Plus Cold, Tylenol Sinus Congestion and Pain Nighttime, or Robitussin Peak Cold Nighttime Nasal Relief if you are allergic to acetaminophen chlorpheniramine phenylephrine or any ingredients contained in this drug.

Cautions:

Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required.
Caution in asthma, bladder neck obstruction, cardiovascular disease, chronic obstructive pulmonary disease (COPD), gastrointestinal (GI) obstruction, glaucoma, hepatic impairment, hyperthyroidism, increased intraocular pressure, malnutrition, renal impairment, elderly patients, patients taking central nervous system (CNS) depressants or under 6 years of age with chlorpheniramine products.
Caution in severe hypovolemia if taking acetaminophen products.
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash.

Pregnancy and Lactation:

There is no information available regarding use of acetaminophen chlorpheniramine phenylephrine during pregnancy or while breastfeeding.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.

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