ACETAMINOPHEN DEXTROMETHORPHAN PHENYLEPHRINE

WHAT IS ACETAMINOPHEN DEXTROMETHORPHAN PHENYLEPHRINE USED FOR AND HOW DOES IT WORK?

Acetaminophen dextromethorphan phenylephrine is an over-the-counter (OTC) product used for symptomatic relief of cough and congestion.

Acetaminophen dextromethorphan phenylephrine is available under the following different brand names: Alka-Seltzer Plus Day Cold, Theraflu Daytime Severe Cold and Cough, Tylenol Cold Multi-Symptom Daytime, Tylenol Cold Head Congestion Daytime, Vicks DayQuil Cold/Flu, Alka-Seltzer Plus Day Severe Cold, Cough and Flu, Alka-Seltzer Plus Day Sinus Congestion, Allergy and Cough, and Alka-Seltzer Plus Severe Sinus Congestion and Cough.

DOSAGES OF ACETAMINOPHEN DEXTROMETHORPHAN PHENYLEPHRINE

Dosage Forms and Strengths:

Caplet:

325mg/10mg/5mg.

Rapid Release Gelcap:

325mg/10mg/5mg.

Capsule:

325mg/10mg/5mg.

Oral Solution:

(80mg/2.5mg/1.25mg)/1mL.

Oral Suspension:

(160mg/5mg/2.5mg)/5mL.

Liquid:

(325mg/10mg/5mg)/15mL.

Powder for Solution:

(650mg/20mg/10mg)/Packet.

Syrup:

(325mg/10mg/5mg)/15mL.

Dosage Considerations – Should be Given as Follows:

Symptomatic Relief of Cough and Congestion.

Adults and Children over 12 years:

1 packet orally every 4 hours; not to exceed 6 doses day.
2 caplets/capsules orally every 4 hours; not to exceed 12 caplets/capsules day.
30 mL liquid/syrup orally every 4 hours; not to exceed 6 doses (12 tablespoons) day.
2 gelcaps every 4 hours; not to exceed 12 gelcaps day.

Children 6-12 years old:

Oral suspension: 10 mL orally every 4 hours; not to exceed 50 mL day.
Oral solution: 4 mL orally every 4 hours as needed; not to exceed 24 mL day.

Children 4-6 years (36-47 pounds):

Oral suspension: 5 mL orally every 4 hours; not to exceed 25 mL day.
Oral solution: 2 mL orally every 4 hours as needed; not to exceed 12 mL day.

Children under 4 years old:

Not recommended.

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING ACETAMINOPHEN DEXTROMETHORPHAN PHENYLEPHRINE?

Common side effects of Acetaminophen Dextromethorphan Phenylephrine include:

High blood pressure (hypertension).
Fast heart rate.
Severe peripheral and visceral vasoconstriction.
Dizziness.
Drowsiness.
Excitability.
Headache.
Restlessness.
Tremors.
Gastrointestinal disturbances.
Anemia blood disorders (neutropenia, pancytopenia, leukopenia).
Bilirubin and alkaline phosphatase may increase.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

WHAT OTHER DRUGS INTERACT WITH ACETAMINOPHEN DEXTROMETHORPHAN PHENYLEPHRINE?

Severe interactions of Acetaminophen Dextromethorphan Phenylephrine include:
iobenguane I 123.
isocarboxazid.
linezolid.
phenelzine.
phenelzine.
procarbazine.
rasagiline.
selegiline transdermal.
safinamide.
selegiline.
tranylcypromine.
Acetaminophen dextromethorphan phenylephrine has serious interactions with at least 44 different drugs.
Acetaminophen dextromethorphan phenylephrine has moderate interactions with at least 232 different drugs.
Acetaminophen dextromethorphan phenylephrine has mild interactions with at least 81 different drugs.
Barbiturates, carbamazepine, hydantoins, isoniazid, and rifampin may increase the hepatotoxic potential of acetaminophen and may decrease the analgesic effects of acetaminophen; cholestyramine may decrease acetaminophen absorption.
Quinidine may inhibit the metabolism of dextromethorphan increasing its toxicity (adjust dose); concurrent use of dextromethorphan with monoamine oxidase inhibitors (MAOIs) may cause hyperpyrexia, abnormal muscle movement, hypotension, coma, and death (avoid use for 2 weeks after stopping the MAO inhibitor; coadministration of dextromethorphan with sibutramine may cause serotonin syndrome (concomitant use not recommended).
Guanethidine may increase pressor response of direct-acting vasopressors, like phenylephrine, possibly resulting in severe hypertension.

WHAT ARE WARNINGS AND PRECAUTIONS FOR ACETAMINOPHEN DEXTROMETHORPHAN PHENYLEPHRINE?

Warnings:

This medication contains acetaminophen dextromethorphan phenylephrine. Do not take Alka-Seltzer Plus Day Cold, Theraflu Daytime Severe Cold and Cough, Tylenol Cold Multi-Symptom Daytime, Tylenol Cold Head Congestion Daytime, Vicks DayQuil Cold/Flu, Alka-Seltzer Plus Day Severe Cold, Cough and Flu, Alka-Seltzer Plus Day Sinus Congestion, Allergy and Cough, or Alka-Seltzer Plus Severe Sinus Congestion and Cough if you are allergic to acetaminophen dextromethorphan phenylephrine or any ingredients contained in this drug.

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