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Actemra Increases Bowel Perforation
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• 08/29/25
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Side Effects
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Here’s a bad side effect you need to be aware of if you’re taking this particular drug.
Tocilizumab (Actemra) markedly increases rate of bowel perforation.
Amy Karon writing in Rheumatology News reported that patients with rheumatoid arthritis were 5 to 9 times more likely than patients on other biologics to develop perforation of the colon. The report comes from a study conducted in Germany after analysis of more than 15,000 patients with rheumatoid arthritis evaluated through the German biologics registry.
Comment: A well known risk but the incidence is a lot higher than we supposed.
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