he combination of Trimethoprim and Sulfonamides (e.g., Sulfamethoxazole) is widely used due to their synergistic effect in inhibiting bacterial folate metabolism. However, their clinical use can lead to several adverse effects:

Common Adverse Effects
Gastrointestinal Disturbances:

Nausea, vomiting, and diarrhea.

Hypersensitivity Reactions:

Rash, fever, and Stevens-Johnson syndrome in severe cases.

Hematologic Toxicity:

Bone marrow suppression, leading to anemia, leukopenia, or thrombocytopenia.

Renal Toxicity:

Crystalluria and interstitial nephritis.

Electrolyte Imbalances:

Hyperkalemia and hyponatremia.

Rare but Serious Effects
Aseptic Meningitis: A rare inflammatory reaction.

Hypoglycemia: Particularly in patients with diabetes or renal impairment.

Pregnancy Risks: Potential teratogenic effects, especially in the first trimester.

Clinical Considerations
Close monitoring is essential, especially in patients with renal or hepatic impairment.

Adequate hydration can help reduce the risk of crystalluria.

#Trimethoprim #Sulfonamide

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Adverse Effects of clinical uses Of Trimethoprim and Sulfonamides Synergy

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