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Allopurinol Pharmacology | Side Effects
Allopurinol (AX) is a drug commonly used to treat gout. Learn about Allopurinol Pharmacology and learn about its aspects in this pharmacology lecture!
▬ 📌 What Is The Mechanism of Action of Allopurinol?
Allopurinol mechanism tells us that it is a Xanthine Oxidase Inhibitor which means it blocks the xanthine oxidase enzyme that is essential for the conversion of hypoxanthine into xanthine and then into uric acid production.
Allopurinol classification: It belongs to Anti-gout agents and Anti-hypouricemic drugs
Learn about the detailed mechanism of allopurinol in thispharmacology video!
▬ 📌 How Does Allopurinol Reduce Uric Acid?
📍It is used in Chronic Gouty Attacks, as it blocks the uric acid production pathway.
📍It is used to prevent hyperuricemia in patients who are taking chemotherapies and cancer treatments.
📍Allopurinol is used to prevent nephropathy due to elevated uric acid levels.
▬ 📌 How Does Allopurinol Work In The Body?
🔹Allopurinol pharmacokinetics are as follows:
🔹Allopurinol does not bind with plasma proteins.
🔹Pharmacokinetics of Allopurinol in the liver: It is metabolized into its active metabolite which is OXYPURINOL. It also gives the same activity as allopurinol hence controlling elevated uric acid levels.
Get to learn how allopurinol works in the body in detail in this video!
▬ 📌 How Quickly Does Allopurinol Work?
Allopurinol mode of action will give you the idea that it only works with newly forming uric acid, so it usually shows action after 2-3 weeks of continuous therapy. Learn more about the Allopurinol mechanism of action in the video!
▬ 📌 Allopurinol Side Effects
Allopurinol has some side effects to be taken care of. These are:
🟡 Allopurinol Hypersensitivity reaction
🟡 Diarrhea
🟡 Vomiting
🟡 GI upset
🟡 Stevens Johnsons Syndrome
🟡 Toxic Epidermal Necrolysis
▬ 📌 Drug Interactions
Drug interactions of allopurinol with other drugs are quite common. Common interactions of Allopurinol are with:
🔵 6 Mercaptopurine
🔵 Azathioprine
🔵 Probenecid
🔵 Aspirin
🔵 Allopurinol and Warfarin interaction
Learn about Allopurinol and alcohol consumption as well in the video!
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