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Antipsychotics Side Effects
Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medications primarily used to manage psychotic disorders such as schizophrenia, schizoaffective disorder, and bipolar disorder. These medications work by targeting and modulating neurotransmitter activity in the brain to alleviate symptoms of psychosis, which can include delusions, hallucinations, disorganized thinking, and agitation.
There are two main classes of antipsychotic medications: typical (first-generation) antipsychotics and atypical (second-generation) antipsychotics. Here's an overview of each:
1. First-Generation Antipsychotics (Typical Antipsychotics):
These were the first medications developed to treat psychosis. They primarily target dopamine receptors in the brain, specifically the D2 receptor. Some examples of first-generation antipsychotics include:
- Haloperidol (Haldol)
- Chlorpromazine (Thorazine)
- Fluphenazine (Prolixin)
- Thioridazine (Mellaril)
While these medications are effective at reducing psychotic symptoms, they often come with a higher risk of side effects, such as movement disorders like tardive dyskinesia, which involves involuntary muscle movements.
2. Second-Generation Antipsychotics (Atypical Antipsychotics):
Atypical antipsychotics were developed to address some of the limitations and side effects associated with first-generation antipsychotics. They target multiple neurotransmitter systems, including dopamine and serotonin, and generally have a lower risk of movement-related side effects. Some examples of atypical antipsychotics include:
- Risperidone (Risperdal)
- Olanzapine (Zyprexa)
- Quetiapine (Seroquel)
- Aripiprazole (Abilify)
- Clozapine (Clozaril)
- Lurasidone (Latuda)
Atypical antipsychotics are often preferred due to their reduced risk of movement disorders, but they can still have side effects such as weight gain, metabolic issues, and sedation. Clozapine, in particular, is reserved for treatment-resistant schizophrenia due to its potential to cause a serious blood disorder called agranulocytosis.
Antipsychotic medications are usually prescribed as part of a comprehensive treatment plan that may include therapy, social support, and lifestyle changes. The choice of which antipsychotic to use depends on factors such as the individual's specific diagnosis, symptom severity, and potential side effect profile. Regular monitoring of both symptoms and side effects is crucial when taking these medications.
It's important to note that while antipsychotics can be highly effective in managing psychosis, they are not without potential risks and side effects. Individuals considering or already taking antipsychotics should have ongoing discussions with their healthcare providers to ensure that the benefits of treatment outweigh any potential drawbacks.

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