→ SHOP MY MERCH HERE: https://bartonella-babe.creator-spring.com

✩ Thank you for supporting my hard work and my channel!

✩ 25% of all proceeds go to the Bartonella Project at the North Carolina State University College of Veterinary Medicine. To donate directly to the Bartonella Project donate via this link through the Bartonella/Vector Borne Disease Research Fund:
https://securelb.imodules.com/s/1209/giving/plain.aspx?sid=1209&gid=214&pgid=3813&cid=6343&appealcode=LB000278&dids=3869&bledit=1&sort=1&fid=6343

I address the issue of antibiotic resistance in the treatment of bartonellosis and compare it to bacterial persistence. I address whether or not complete eradication of Bartonella is possible. I also talk about if and when pulsing antibiotics for bartonellosis is appropriate and the risks of pulsing rifampin based on the ScIeNtIfIc LiTeRaTuRe.

Videos referenced:
→ Start here! Treatment of bartonellosis: https://www.youtube.com/watch?v=UYJ60caQzWA
→ Galaxy's webinar with Dr. Mozayeni (and Dr. Breitschwerdt): https://www.youtube.com/watch?v=NJYwMMPJIkU&t=2301s
→ Jack and Amy's bartonellosis success story!: https://www.youtube.com/watch?v=ZI3v_D5ndpw&t=10s

Time stamps
✩ Intro: 0:00
✩ Diff b/w rifampin and rifabutin and rifampin resistance: 3:28
→ Penetration of rifampin vs. rifabutin
→ Persistence in biofilms
→ Persistence in tissue cysts (Bartonella do not have a cyst form)
→ Macrolide resistance
→ Plateauing on rifampin and clarithromycin
→ Why rifamycins are effective in latent infections
✩ Can Bartonella be eradicated? 11:30
✩ Pulsing antibiotics for bartonellosis? 13:22
✩ Pulsing rifampin? 15:43

✩Instagram: @bartonella_babe https://www.instagram.com/bartonella_babe/
✩Facebook: www.facebook.com/bartonellababe
✩Inquiries: [email protected]

JOIN our NEW BREAKING DOWN BARTONELLA Facebook educational/support group:
https://www.facebook.com/groups/1104493829902071/

Best diagnostic testing:
www.galaxydx.com

Dr. B. Robert Mozayeni's research use only confocal laser scanning microscope with fluorescent tags for Bartonella henselae:
https://www.tlabdx.com/

Studies referenced:
REF 1 Battaglia, R., Salgarollo, G., Zini, G., Montesanti, L., & Benedetti, M. S. (1991). Absorption, disposition, and urinary metabolism of 14C-rifabutin in rats. Antimicrobial agents and chemotherapy, 35(7), 1391-1396. https://aac.asm.org/content/aac/35/7/1391.full.pdf
REF 2 Willing, B. P., Pepin, D. M., Marcolla, C. S., Forgie, A. J., Diether, N. E., & Bourrie, B. C. (2018). Bacterial resistance to antibiotic alternatives: a wolf in sheep’s clothing?. Animal Frontiers, 8(2), 39-47.
https://academic.oup.com/af/article/8/2/39/4990302
REF 3 Biswas, S., Raoult, D., & Rolain, J. M. (2006). Molecular characterization of resistance to macrolides in Bartonella henselae. Antimicrobial agents and chemotherapy, 50(9), 3192-3193. https://aac.asm.org/content/aac/50/9/3192.full.pdf
REF 4 Crabol, Y., Catherinot, E., Veziris, N., Jullien, V., & Lortholary, O. (2016). Rifabutin: where do we stand in 2016?. Journal of Antimicrobial Chemotherapy, 71(7), 1759-1771.
https://academic.oup.com/jac/a....rticle/71/7/1759/175
REF 5 Rothstein, D. M. (2016). Rifamycins, alone and in combination. Cold Spring Harbor perspectives in medicine, 6(7), a027011.
http://perspectivesinmedicine.....cshlp.org/content/6/
REF 6 Dickinson, J. M., & Mitchison, D. A. (1981). Experimental models to explain the high sterilizing activity of rifampin in the chemotherapy of tuberculosis. American Review of Respiratory Disease, 123(4), 367-371.
REF 7 Grosset, J., & Leventis, S. (1983). Adverse effects of rifampin. Reviews of infectious diseases, 5(Supplement_3), S440-S446.
REF 8 Havey, T. C., Cserti-Gazdewich, C., Sholzberg, M., Keystone, J. S., & Gold, W. L. (2012). Recurrent disseminated intravascular coagulation caused by intermittent dosing of rifampin. The American journal of tropical medicine and hygiene, 86(2), 264-267.
https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC32692
REF 9 Poole, G., Stradling, P., & Worlledge, S. (1971). Potentially serious side effects of high-dose twice-weekly rifampicin. Br Med J, 3(5770), 343-347.
https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC17986
REF 10 Flynn, C. T., Rainford, D. J., & Hope, E. (1974). Acute renal failure and rifampicin: danger of unsuspected intermittent dosage. British Medical Journal, 2(5917), 482.
https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC16106
REF 11 Sadanshiv, M., George, A. A., Mishra, A. K., & Kuriakose, C. K. (2018). Rifampicin-induced immune allergic reaction. Tropical Doctor, 48(2), 156-159.
https://www.researchgate.net/p....rofile/Ajay_Mishra26

#Bartonellosis #Bartonella #Bartonellatreatment #BartonellaBabe #Bartonellasymptoms

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