Time Stamps

Formulations 0:43
Beta-IFN Production 2:02
Mechanism of Action 4:02
Pharmacology 5:36
Clinical Trial Results 6:13
Side Effects 7:42
Neutralizing Antibodies 11:29
Pregnancy 14:53
Monitoring 16:55

Beta Interferons for multiple sclerosis include the formuations betaseron, avonex, extavia, rebif, and plegridy. They are older MS medications but have an excellent safety profile.

Sources:

 1) betaseron product label: http://www.fda.gov/downloads/D....rugs/DevelopmentAppr
 2) 1. Poser CM, et al. Ann Neurol 1983; 13(3): 227; 231. 2. Kurtzke JF. Neurology 1983; 33(11): 1444; 1452.
 3) Avonex package insert: http://www.fda.gov/downloads/D....rugs/DevelopmentAppr
 4) Rebif package insert: http://www.accessdata.fda.gov/....drugsatfda_docs/labe
 5) Avonex product annex: http://www.ema.europa.eu/docs/....en_GB/document_libra
 6) pooled studies described by rxlist: http://www.rxlist.com/betasero....n-side-effects-drug-
 7) “Final results from the Betaseron (interferon β-1b) Pregnancy Registry: a prospective observational study of birth defects and pregnancy-related adverse events.”; BMJ Open. 2014 May 12;4(5):e004536. doi: 10.1136/bmjopen-2013-004536.; Coyle PK1, Sinclair SM, Scheuerle AE, Thorp JM Jr, Albano JD, Rametta MJ.
 8) “Anaplastic oligodendroglioma and gliomatosis type 2 in interferon-beta treated multiple sclerosis patients. Report of two cases.” Clin Neurol Neurosurg. 2006 Mar;108(3):259-65. Epub 2005 Dec 27; Sega S1, Horvat A, Popovic M.
 9) “Lethal capillary leak syndrome after a single administration of interferon beta-1b.”Neurology. 1999 Jul 13;53(1):220-2;
 Schmidt S1, Hertfelder HJ, von Spiegel T, Hering R, Harzheim M, Lassmann H, Deckert-Schlüter M, Schlegel U.
 10 ) “Occurrence of Psoriatic Arthritis during Interferon Beta 1a Treatment for Multiple Sclerosis.; Case Rep Rheumatol. 2014;2014:949317. doi: 10.1155/2014/949317. Epub 2014 Apr 15.; Toussirot E1, Béreau M2, Bossert M3, Malkoun I4, Lohse A3.
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

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