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Clindamycin (Cleocin) – Uses, Side Effects, Mechanism of Action, Dosage, Interactions, Warnings
Clindamycin (Cleocin) – Uses, Side Effects, Mechanism of Action, Dosage, Interactions, Warnings
Clindamycin (Cleocin) is a lincosamide antibiotic used to treat a variety of bacterial infections, including skin, respiratory, bone, intra-abdominal, gynecological, dental infections, and acne. It works by inhibiting bacterial protein synthesis via binding to the 50S ribosomal subunit, primarily acting against Gram-positive bacteria and anaerobes. It is usually bacteriostatic but may be bactericidal at higher concentrations. Common side effects include diarrhea, nausea, abdominal pain, and rash, while serious adverse effects can involve C. difficile-associated diarrhea, Stevens-Johnson syndrome, hepatotoxicity, and blood dyscrasias. Dosage varies by infection severity and route, with oral, intravenous, topical, and vaginal formulations available. Key drug interactions include enhanced effects with neuromuscular blockers and antagonism with erythromycin. Caution is advised in hepatic impairment, pregnancy, breastfeeding, and patients with known allergies to clindamycin or lincomycin.
#clindamycin #cleocin #clindamycinsideeffects #cleocinsideeffects #clindamycinuses #cleocinuses
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