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Divalproex Nursing Considerations, Side Effects, and Mechanism of Action Pharmacology for Nurses

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Divalproex (valproic acid derivative)

Generic Name: divalproex

Trade Name: Depakote

Indication: seizures, manic episodes, prevention of headache

Action: increases the level of GABA (inhibitory neurotransmitter) in CNS

Therapeutic Class: Anticonvulsant, vascular headache suppressants

Pharmacologic Class: none

Nursing Considerations:
 may cause suicidal thoughts, agitation, dizziness, insomnia, hepatotoxicity, pancreatitis
 increases risk for bleeding with Warfarin
 use caution with MAOIs
 monitor liver function tests

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