Esomeprazole Is Superior To Omeprazole

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Video transcript :-
Esomeprazole belongs to the drug class of proton pump inhibitors which are used to treat conditions with acid-related gastrointestinal disorders.
Major indications of esomeprazole include the following.
Gastroesophageal reflux disease.
Peptic ulcer disease.
Erosive esophagitis.
Zollinger-Ellison syndrome, where there is hypersecretion of gastric acid.
As a part of the Helicobacter pylori eradication therapy.
Prevention of non-steroidal anti-inflammatory drug-induced ulcers, and stress ulcers.
Esomeprazole works by inhibiting the hydrogen potassium ATP ase, also known as the proton pump, in the parietal cells of the stomach.
This action leads to irreversible inhibition of gastric acid secretion and reduced gastric acidity, aiding ulcer healing and symptom relief in acid related disorders.
Esomeprazole is commonly administered orally as tablets or capsules.
It has a good oral bioavailability of about 50 to 60%, which is higher than that of omeprazole.
Intravenous route is reserved for emergency situations where rapid administration is required, and when oral omeprazole is not tolerable.
The drug is primarily metabolized in the liver by the enzymes CYP2C19 and CYP3A4 and is excreted mainly in the urine as inactive metabolites.
Common adverse effects of esomeprazole include the following.
Gastrointestinal effects such as nausea, diarrhea or constipation, abdominal pain, and bloating.
Neurological effects such as headache and dizziness.
Long term effects such as Vitamin B12 deficiency due to reduced gastric acid needed for absorption, hypomagnesemia due to reduced magnesium absorption, increased risk of fractures, due to impaired calcium absorption, and increased risk of Clostridium difficile infection.
Absolute contraindications include Hypersensitivity to esomeprazole or other proton pump inhibitors, and Co-administration with certain antiretroviral drugs such as atazanavir and rilpivirine due to reduced drug absorption
Relative contraindications include severe hepatic impairment, osteoporosis, and hypomagnesemia.

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