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Glimepiride, Glyburide, Glipizide. Everything about Sulfonylureas!
Sulfonylureas (SU) were discovered in the 1950's. In this class, glimepiride, glyburide and glipizide are the most commonly used in the United States today.
Sulfonylureas are only indicated for type 2 diabetes. They are not used in Type 1 Diabetes. To date, only insulin is approved for the treatment of type 1 Diabetes.
Metformin is used first line for the treatment of type 2 diabetes. Sulfonylureas are widely used after metformin. However, the ADA guidelines recommend this class of medications last. We are now using newer classes that work better in the management of type 2 diabetes.
SU's are generic and are inexpensive. They work by telling your pancreas to make more insulin. One of the defects in type 2 diabetes is that the pancreas is unable to produce adequate amount of insulin therefore causing higher than normal blood sugar levels.
Although these medications are inexpensive, they are not favored. They can cause hypoglycemia (low blood sugar levels) and can lead to weight gain amongst other possible side effects. Additionally, people who are started on SU's early on in the disease process are more likely to require insulin earlier on.
SU's can reduce hba1c by nearly 2% which is significant reduction.
Timecodes:
00:00 Intro
01:41 Most commonly used Sulfonylureas
03:22 Pros of using Sulfonylureas
03:52 How glimepiride, glyburide and glipizide work
05:00 SU side effects
08:30 SU's and kidney disease
10:20 SU's and chemotherapy or steroid use
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Disclaimer: The information on this channel (The Voice of Diabetes) is provided as an information resource ONLY. It is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician (APRN) relationship, and should not be used as a substitute for professional diagnosis and treatment. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. Diana Bytyqi, DNP, FNP-C, shall have no liability for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained on this site.
#sulfonylureas #glipizide #glyburide #glimepiride #thevoiceofdiabetes #lowerbloodsugar #controldiabetes #diabetes #type2diabetes #hypoglycemia #avoidlowbloodsugars #diabetesmanagment #hba1c
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