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Griseofulvin Tablet | Uses | Side Effects | Doses | Anti fungal
Griseofulvin
Griseofulvin is a Heterocyclic Benzofuran antifungal Drug.
Griseofulvin is fungistatic for most dermatophytes, including Epidermophyton, Trichophyton and Microsporum, etc., but not against Candida And other fungi causing deep mycosis.
It was one of the early antibiotics extracted from Penicillium griseofulvum. However, because of lack of antibacterial activity, little attention was paid to it: clinical utility in dermatophytosis was demonstrated only around 1960.
Mechanism
Griseofulvin binds to Tubulin (Protein in nucleus) interfering With microtubules function.
Griseofulvin inhibits fungal cell mitosis.
Griseofulvin gets deposited in Keratin forming cells of skin hairs, nails and protect Skin, hairs, nails from getting newly Infection.
The absorption of Griseofulvin from Gastrointestinal Tract it’s somewhat irregular because of its very low water solubility.
Absorption is improved by using Microfined particles and taking it with fatty food.
Route of administration – Orally only ( Tablet and Syrup )
Half life – 9-20 hours
Doses –
125–250 mg QID with meals; duration depends on the Site of infection (turnover rate of keratin).
Scalp 4 weeks
Palm, soles 6 to 8 weeks
Finger nails 6 to 8 months
Toe nails 10 to 12 months
Uses
Superficial Dermatophytosis (Superficial Skin fungal Infections)
Tinea Corporis / Ringworm
- Infection of the skin that can affect any part of the body excluding scale, face, beard and nail.
Tinea Barbae
- Fungal Infection of the beard and moustache areas.
Tinea Capitis
- Fungal Infection of the skin of scalp, eyebrows.
Tinea Unguium / Onychomycosis
- Fungal Infection of Nail
Tinea Pedis / Athlete’s foot
- Fungal Infection between the toes
Tinea Cruris / Jock itch
- Fungal Infection in the skin of the genital, inner, underarm and buttocks.
Side Effects
Nausea And Vomiting
Headache
Diarrhea
Sore throat
Mouth ulcer
Stomach upset
Skin Rash
Muscles pain
Decreased WBC count.
Contraindications and Warnings
Hypersensitivity to Griseofulvin or any component of formulation.
Pregnancy
Hepatic failure
Porphyria (Blood Disorders)
WBC breakdown , Anemia
Avoid Alcohol
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