Heparin is one of the anti-coagulant medication. It indirectly inhibits two clotting factor by enhancing the activity of antithrombin 3.

The activity of heparin depends on the chemical structure. UFH contains HMWH and LMWH, where fractionated heparin contains only LMWH. Fondaparinux has action similar to that of LMWH.

For side effects, bleeding is the most common complication. On the other hand, heparin induced thrombocytopenia (HIT) can cause paradoxical thrombosis, more commonly seen with UFH.

0:00 Introduction
0:32 Coagulation cascade
2:51 Antithrombin 3 (anticoagulant)
3:48 Mechanism of action of heparin
4:41 HMWH and LMWH
5:23 Heparin preparations
7:07 Uses
8:28 Monitoring therapeutic efficacy
10:04 Heparin induced thrombocytopenia

#thingyansane #heparin #pharmacology #anticoagulant

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